ZA200605882B - Pharmaceutical formulations comprising metformin and a fibrate, and processes for obtaining them - Google Patents

Pharmaceutical formulations comprising metformin and a fibrate, and processes for obtaining them

Info

Publication number
ZA200605882B
ZA200605882B ZA200605882A ZA200605882A ZA200605882B ZA 200605882 B ZA200605882 B ZA 200605882B ZA 200605882 A ZA200605882 A ZA 200605882A ZA 200605882 A ZA200605882 A ZA 200605882A ZA 200605882 B ZA200605882 B ZA 200605882B
Authority
ZA
South Africa
Prior art keywords
fibrate
metformin
processes
obtaining
pharmaceutical formulations
Prior art date
Application number
ZA200605882A
Other languages
English (en)
Inventor
Dawson Gordon
Mc Carthy Leonard
Original Assignee
Fournier Lab Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Ireland Ltd filed Critical Fournier Lab Ireland Ltd
Publication of ZA200605882B publication Critical patent/ZA200605882B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200605882A 2004-01-23 2005-01-24 Pharmaceutical formulations comprising metformin and a fibrate, and processes for obtaining them ZA200605882B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04001499A EP1559419A1 (fr) 2004-01-23 2004-01-23 Composition pharmaceutique contenant une combinaison de mefformine et d'un fibrate et les procédés pour les obtenir

Publications (1)

Publication Number Publication Date
ZA200605882B true ZA200605882B (en) 2009-03-25

Family

ID=34639372

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200605882A ZA200605882B (en) 2004-01-23 2005-01-24 Pharmaceutical formulations comprising metformin and a fibrate, and processes for obtaining them

Country Status (21)

Country Link
US (2) US20080020046A1 (fr)
EP (2) EP1559419A1 (fr)
JP (1) JP4740881B2 (fr)
CN (1) CN100531722C (fr)
AT (1) ATE521338T1 (fr)
AU (1) AU2005205930B2 (fr)
BR (1) BRPI0507022A (fr)
CA (1) CA2553967A1 (fr)
CY (1) CY1111961T1 (fr)
DK (1) DK1706102T3 (fr)
EA (1) EA009773B1 (fr)
ES (1) ES2370948T3 (fr)
IL (1) IL176903A0 (fr)
MA (1) MA28353A1 (fr)
NO (1) NO20062792L (fr)
PL (1) PL1706102T3 (fr)
PT (1) PT1706102E (fr)
SI (1) SI1706102T1 (fr)
TN (1) TNSN06222A1 (fr)
WO (1) WO2005070396A1 (fr)
ZA (1) ZA200605882B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600371A (es) * 2005-08-17 2007-03-21 Formas de dosis sólidas de valsartan y amlodipina y método para hacer las mismas
EP2026833A4 (fr) * 2006-06-01 2012-05-30 Univ Vermont Procédés destinés à inhiber le pai-1 cardiaque
CA2672686A1 (fr) * 2006-10-12 2008-04-17 Abbott Laboratories Formulations pharmaceutiques
CA2638240C (fr) * 2008-08-29 2010-02-02 Alexander Macgregor Methode de traitement des anomalies de la glycemie et des variations de la glycemie
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
UY32919A (es) 2009-10-02 2011-04-29 Boehringer Ingelheim Int Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos
WO2011154013A1 (fr) * 2010-06-10 2011-12-15 Lifecycle Pharma A/S Composition pharmaceutique comprenant un acide fénofibrique
MX363549B (es) * 2010-09-21 2019-03-26 Intekrin Therapeutics Inc Star Composiciones farmacéuticas sólidas antidiabéticas.
WO2013064853A1 (fr) * 2011-11-05 2013-05-10 Lupin Atlantis Holdings, S.A. Compositions pharmaceutiques orales à dose réduite de fénofibrate
WO2013077821A1 (fr) * 2011-11-23 2013-05-30 Mahmut Bilgic Composition homogène contenant un biguanide
WO2014091318A1 (fr) * 2012-12-11 2014-06-19 Lupin Atlantis Holdings, S.A. Compositions pharmaceutiques à dose réduite de fénofibrate
MA41202A (fr) * 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
WO2016144766A1 (fr) * 2015-03-06 2016-09-15 The University Of North Carolina At Chapel Hill Metformine polymère et son utilisation comme agent thérapeutique et comme véhicule d'administration
JP2018507914A (ja) 2015-03-09 2018-03-22 インテクリン・セラピューティクス・インコーポレイテッド 非アルコール性脂肪肝疾患および／またはリポジストロフィーの処置のための方法
JP2020515639A (ja) 2017-04-03 2020-05-28 コヒラス・バイオサイエンシズ・インコーポレイテッド 進行性核上性麻痺の処置のためのＰＰＡＲγアゴニスト
WO2022023213A1 (fr) * 2020-07-31 2022-02-03 Krka, D. D., Novo Mesto Formulation pharmaceutique de metformine ayant une faible teneur en diméthylamine
WO2023234935A1 (fr) * 2022-05-31 2023-12-07 Venkor Corporation Préparation de microparticules liées et applications associées

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907792A (en) * 1969-01-31 1975-09-23 Andre Mieville Phenoxy-alkyl-carboxylic acid derivatives and the preparation thereof
US4250191A (en) * 1978-11-30 1981-02-10 Edwards K David Preventing renal failure
US4499289A (en) * 1982-12-03 1985-02-12 G. D. Searle & Co. Octahydronapthalenes
US4686237A (en) * 1984-07-24 1987-08-11 Sandoz Pharmaceuticals Corp. Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
US5177080A (en) * 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
AU660852B2 (en) * 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
US5336507A (en) * 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
TW384224B (en) * 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US5718388A (en) * 1994-05-25 1998-02-17 Eastman Kodak Continuous method of grinding pharmaceutical substances
US5560932A (en) * 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5665331A (en) * 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
US5534270A (en) * 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5543133A (en) * 1995-02-14 1996-08-06 Nanosystems L.L.C. Process of preparing x-ray contrast compositions containing nanoparticles
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
FR2774591B1 (fr) * 1998-02-12 2000-05-05 Lipha Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
EA003101B1 (ru) * 1998-03-19 2002-12-26 Бристол-Майерз Сквибб Компани Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ лечения диабета с помощью этой системы
US6531158B1 (en) * 2000-08-09 2003-03-11 Impax Laboratories, Inc. Drug delivery system for enhanced bioavailability of hydrophobic active ingredients
US20030224058A1 (en) * 2002-05-24 2003-12-04 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
EP1424070A1 (fr) * 2002-11-28 2004-06-02 Fournier Laboratories Ireland Limited Combinaison d'un agoniste de PPAR-alpha et de metformine pour la réduction du taux de triglycérides sériques

Also Published As

Publication number Publication date
CN1909890A (zh) 2007-02-07
BRPI0507022A (pt) 2007-06-05
EA200601215A1 (ru) 2007-02-27
AU2005205930A1 (en) 2005-08-04
DK1706102T3 (da) 2011-12-19
PT1706102E (pt) 2011-12-16
EP1559419A1 (fr) 2005-08-03
WO2005070396A1 (fr) 2005-08-04
JP2007518773A (ja) 2007-07-12
EA009773B1 (ru) 2008-04-28
AU2005205930B2 (en) 2007-09-20
CN100531722C (zh) 2009-08-26
MA28353A1 (fr) 2006-12-01
ATE521338T1 (de) 2011-09-15
US20080020046A1 (en) 2008-01-24
EP1706102B1 (fr) 2011-08-24
PL1706102T3 (pl) 2012-01-31
SI1706102T1 (sl) 2011-12-30
CY1111961T1 (el) 2015-11-04
NO20062792L (no) 2006-09-25
CA2553967A1 (fr) 2005-08-04
JP4740881B2 (ja) 2011-08-03
IL176903A0 (en) 2006-12-10
ES2370948T3 (es) 2011-12-26
US20110305733A1 (en) 2011-12-15
EP1706102A1 (fr) 2006-10-04
TNSN06222A1 (en) 2007-12-03

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