ZA200604718B - N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein B - Google Patents
N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein B Download PDFInfo
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- ZA200604718B ZA200604718B ZA200604718A ZA200604718A ZA200604718B ZA 200604718 B ZA200604718 B ZA 200604718B ZA 200604718 A ZA200604718 A ZA 200604718A ZA 200604718 A ZA200604718 A ZA 200604718A ZA 200604718 B ZA200604718 B ZA 200604718B
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104601 | 2003-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200604718B true ZA200604718B (en) | 2007-10-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200604718A ZA200604718B (en) | 2003-12-09 | 2006-06-08 | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein B |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8772494B2 (fr) |
| EP (1) | EP1694644B1 (fr) |
| JP (1) | JP4790626B2 (fr) |
| KR (1) | KR101125120B1 (fr) |
| CN (1) | CN100548985C (fr) |
| AT (1) | ATE548350T1 (fr) |
| AU (1) | AU2004299295B2 (fr) |
| BR (1) | BRPI0417469B8 (fr) |
| CA (1) | CA2547243C (fr) |
| EA (1) | EA009081B1 (fr) |
| ES (1) | ES2383179T3 (fr) |
| HK (1) | HK1100559A1 (fr) |
| IL (1) | IL176171A (fr) |
| NO (1) | NO337251B1 (fr) |
| NZ (1) | NZ546964A (fr) |
| SG (1) | SG149001A1 (fr) |
| UA (1) | UA83510C2 (fr) |
| WO (1) | WO2005058824A2 (fr) |
| ZA (1) | ZA200604718B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1948629A1 (fr) * | 2005-10-31 | 2008-07-30 | Janssen Pharmaceutica N.V. | Piperazines et piperidines substituees en tant que modulateurs du recepteur du neuropeptide y2 |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| PL2666859T3 (pl) | 2006-04-03 | 2019-09-30 | Roche Innovation Center Copenhagen A/S | Kompozycja farmaceutyczna zawierająca antysensowne oligonukleotydy anty-miRNA |
| ES2715625T3 (es) | 2006-04-03 | 2019-06-05 | Roche Innovation Ct Copenhagen As | Composición farmacéutica que comprende oligonucleótidos antisentido anti-miARN |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| DK2149605T3 (da) | 2007-03-22 | 2013-09-30 | Santaris Pharma As | Korte RNA antagonist forbindelser til modulering af det ønskede mRNA |
| EP2126079A1 (fr) | 2007-03-22 | 2009-12-02 | Santaris Pharma A/S | Composés arn antagonistes pour l'inhibition de l'expression de l'apo-b100 |
| JP6035010B2 (ja) | 2007-10-04 | 2016-11-30 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ | マイクロｍｉｒ |
| EP2268811A1 (fr) | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Compositions pharmaceutiques pour le traitement de maladies associées aux microarn |
| US8492357B2 (en) | 2008-08-01 | 2013-07-23 | Santaris Pharma A/S | Micro-RNA mediated modulation of colony stimulating factors |
| WO2010122538A1 (fr) | 2009-04-24 | 2010-10-28 | Santaris Pharma A/S | Compositions pharmaceutiques pour le traitement de patients souffrant du vhc ne réagissant pas aux interférons |
| WO2011009697A1 (fr) | 2009-07-21 | 2011-01-27 | Santaris Pharma A/S | Oligomères anti-sens ciblant pcsk9 |
| EP3591054A1 (fr) | 2013-06-27 | 2020-01-08 | Roche Innovation Center Copenhagen A/S | Oligomères et conjugués antisens ciblant pcsk9 |
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| GB9826412D0 (en) * | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
| GB0013383D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Therapeutic benzamide derivatives |
| GB0013378D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Use of therapeutic benzamide derivatives |
| JO2654B1 (en) * | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2390B1 (en) * | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
| GB0109287D0 (en) * | 2001-04-12 | 2001-05-30 | Glaxo Group Ltd | Therapeutic benzamide derivatives |
| GB0129015D0 (en) | 2001-12-04 | 2002-01-23 | Glaxo Group Ltd | Compounds |
| UA79300C2 (en) * | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
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2004
- 2004-06-12 UA UAA200605783A patent/UA83510C2/uk unknown
- 2004-12-06 ES ES04804685T patent/ES2383179T3/es active Active
- 2004-12-06 WO PCT/EP2004/053280 patent/WO2005058824A2/fr active Application Filing
- 2004-12-06 SG SG200809026-8A patent/SG149001A1/en unknown
- 2004-12-06 CN CNB2004800362613A patent/CN100548985C/zh not_active Expired - Fee Related
- 2004-12-06 EA EA200601120A patent/EA009081B1/ru not_active IP Right Cessation
- 2004-12-06 AT AT04804685T patent/ATE548350T1/de active
- 2004-12-06 NZ NZ546964A patent/NZ546964A/en not_active IP Right Cessation
- 2004-12-06 JP JP2006543538A patent/JP4790626B2/ja not_active Expired - Fee Related
- 2004-12-06 US US10/580,530 patent/US8772494B2/en not_active Expired - Fee Related
- 2004-12-06 KR KR1020067013049A patent/KR101125120B1/ko active IP Right Grant
- 2004-12-06 AU AU2004299295A patent/AU2004299295B2/en not_active Ceased
- 2004-12-06 BR BRPI0417469A patent/BRPI0417469B8/pt not_active IP Right Cessation
- 2004-12-06 CA CA2547243A patent/CA2547243C/fr not_active Expired - Fee Related
- 2004-12-06 EP EP04804685A patent/EP1694644B1/fr active Active
-
2006
- 2006-06-07 IL IL176171A patent/IL176171A/en active IP Right Grant
- 2006-06-08 ZA ZA200604718A patent/ZA200604718B/en unknown
- 2006-07-04 NO NO20063103A patent/NO337251B1/no not_active IP Right Cessation
-
2007
- 2007-05-30 HK HK07105744.1A patent/HK1100559A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SG149001A1 (en) | 2009-01-29 |
| US20070099934A1 (en) | 2007-05-03 |
| WO2005058824A2 (fr) | 2005-06-30 |
| ES2383179T3 (es) | 2012-06-18 |
| BRPI0417469B1 (pt) | 2019-06-25 |
| KR101125120B1 (ko) | 2012-03-21 |
| NO337251B1 (no) | 2016-02-22 |
| KR20060111628A (ko) | 2006-10-27 |
| EP1694644B1 (fr) | 2012-03-07 |
| UA83510C2 (en) | 2008-07-25 |
| JP2007513921A (ja) | 2007-05-31 |
| NO20063103L (no) | 2006-09-05 |
| EA009081B1 (ru) | 2007-10-26 |
| ATE548350T1 (de) | 2012-03-15 |
| CN100548985C (zh) | 2009-10-14 |
| CA2547243A1 (fr) | 2005-06-30 |
| WO2005058824A3 (fr) | 2005-10-27 |
| HK1100559A1 (en) | 2007-09-21 |
| CA2547243C (fr) | 2012-10-23 |
| BRPI0417469A (pt) | 2007-04-10 |
| BRPI0417469B8 (pt) | 2021-05-25 |
| US8772494B2 (en) | 2014-07-08 |
| JP4790626B2 (ja) | 2011-10-12 |
| IL176171A0 (en) | 2006-10-05 |
| EA200601120A1 (ru) | 2006-10-27 |
| AU2004299295B2 (en) | 2010-07-15 |
| CN1890217A (zh) | 2007-01-03 |
| EP1694644A2 (fr) | 2006-08-30 |
| IL176171A (en) | 2013-08-29 |
| NZ546964A (en) | 2009-03-31 |
| AU2004299295A1 (en) | 2005-06-30 |
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