ZA200603887B - Novewl imaging agents comprising caspase-3 inhibitors - Google Patents

Novewl imaging agents comprising caspase-3 inhibitors Download PDF

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Publication number
ZA200603887B
ZA200603887B ZA200603887A ZA200603887A ZA200603887B ZA 200603887 B ZA200603887 B ZA 200603887B ZA 200603887 A ZA200603887 A ZA 200603887A ZA 200603887 A ZA200603887 A ZA 200603887A ZA 200603887 B ZA200603887 B ZA 200603887B
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South Africa
Prior art keywords
caspase
formula
alkyl
radioactive
inhibitor
Prior art date
Application number
ZA200603887A
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English (en)
Inventor
Hiscock Duncan
Guilbert Benedicte
Newton Ben
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of ZA200603887B publication Critical patent/ZA200603887B/en

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/0429Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K51/0431Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • AHUMAN NECESSITIES
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    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61P35/00Antineoplastic agents
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
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  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
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  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
ZA200603887A 2003-11-26 2006-05-15 Novewl imaging agents comprising caspase-3 inhibitors ZA200603887B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0327494.1A GB0327494D0 (en) 2003-11-26 2003-11-26 Novel imaging agents

Publications (1)

Publication Number Publication Date
ZA200603887B true ZA200603887B (en) 2008-02-27

Family

ID=29797853

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200603887A ZA200603887B (en) 2003-11-26 2006-05-15 Novewl imaging agents comprising caspase-3 inhibitors

Country Status (15)

Country Link
US (1) US20060275215A1 (fr)
EP (1) EP1763371A2 (fr)
JP (1) JP2007512302A (fr)
KR (1) KR101236124B1 (fr)
CN (1) CN1905904B (fr)
AU (1) AU2004294784B2 (fr)
BR (1) BRPI0416938A (fr)
CA (1) CA2547236A1 (fr)
GB (1) GB0327494D0 (fr)
IL (1) IL175667A (fr)
MX (1) MXPA06006045A (fr)
NO (1) NO20062387L (fr)
RU (1) RU2006117819A (fr)
WO (1) WO2005053752A2 (fr)
ZA (1) ZA200603887B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006006156A2 (fr) * 2004-07-08 2006-01-19 Nst Neurosurvival Technologies Ltd Methodes et composes permettant de detecter des troubles medicaux
CA2594770C (fr) 2005-01-17 2013-10-15 Universitatsklinikum Munster Derives de la 5-pyrrolidinylsulfonyl isatine
GB0502277D0 (en) * 2005-02-04 2005-03-09 Amersham Plc Novel imaging agents
AU2006306592A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis
GB0610395D0 (en) * 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
US10328164B2 (en) * 2006-06-21 2019-06-25 Ge Healthcare Limited Radiopharmaceutical products
GB0612333D0 (en) * 2006-06-21 2006-08-02 Ge Healthcare Ltd Radiopharmaceutical products
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
KR100845010B1 (ko) * 2007-08-29 2008-07-08 한국생명공학연구원 Nir/mr 이중모드 분자영상용 고분자 입자 및 그제조방법
US9005577B2 (en) * 2008-04-30 2015-04-14 Siemens Medical Solutions Usa, Inc. Substrate based PET imaging agents
WO2010028156A2 (fr) * 2008-09-04 2010-03-11 Board Of Regents, The University Of Texas System Détection d'apoptose à double modalité
RU2535975C2 (ru) 2008-09-05 2014-12-20 Империал Инновейшнз Лимитед Производные изатина для применения в качестве агентов визуализации in vivo
GB0818738D0 (en) * 2008-10-13 2008-11-19 Ge Healthcare Ltd Imaging neuroflammation
US10188754B2 (en) 2013-05-16 2019-01-29 The Johns Hopkins University Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI)
WO2017053864A1 (fr) * 2015-09-23 2017-03-30 Intracellular Technologies, Llc Inhibiteurs de protéases à cystéine
CN107655871A (zh) * 2017-09-12 2018-02-02 重庆医科大学 一种阿仑膦酸钠的高灵敏宽检测范围荧光检测新方法
AU2022407451A1 (en) * 2021-12-08 2024-07-18 Cytosite Biopharma Inc. Compounds specific to granzyme b and uses thereof

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US5601801A (en) * 1994-08-02 1997-02-11 Merck Frosst Canada, Inc. Radiolabelled angiotensin converting enzyme inhibitors
AR016384A1 (es) * 1997-07-30 2001-07-04 Smithkline Beecham Corp Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta.
US6589503B1 (en) * 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
WO2001089584A2 (fr) * 2000-05-23 2001-11-29 Amersham Health As Agents de contraste
NO20002644D0 (no) * 2000-05-23 2000-05-23 Nycomed Imaging As Kontrastmiddel
CA2710031A1 (fr) * 2001-03-02 2002-09-12 University Of Western Ontario Precurseurs polymeres de composes radiomarques et methodes de fabrication et d'utilisation de ceux-ci
US20060147378A1 (en) * 2002-09-24 2006-07-06 Ching-Hsuan Tung Azulene dimer-quenched, near-infrared fluorescent probes
EP1594819A1 (fr) * 2003-02-07 2005-11-16 Merck Frosst Canada & Co. Inhibiteurs irreversibles de la caspase-3 servant de sondes a des sites actifs
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa

Also Published As

Publication number Publication date
AU2004294784A1 (en) 2005-06-16
CA2547236A1 (fr) 2005-06-16
IL175667A0 (en) 2006-09-05
CN1905904B (zh) 2011-12-21
NO20062387L (no) 2006-05-31
RU2006117819A (ru) 2008-01-10
JP2007512302A (ja) 2007-05-17
KR101236124B1 (ko) 2013-02-21
IL175667A (en) 2013-09-30
AU2004294784B2 (en) 2008-04-24
BRPI0416938A (pt) 2007-02-13
WO2005053752A3 (fr) 2005-10-06
GB0327494D0 (en) 2003-12-31
KR20060123196A (ko) 2006-12-01
MXPA06006045A (es) 2006-08-23
WO2005053752A2 (fr) 2005-06-16
CN1905904A (zh) 2007-01-31
US20060275215A1 (en) 2006-12-07
EP1763371A2 (fr) 2007-03-21

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