ZA200603597B - Combination of a farnesyl transferase inhibitor with an anti-hormonal agent for the treatment of breast cancer - Google Patents
Combination of a farnesyl transferase inhibitor with an anti-hormonal agent for the treatment of breast cancer Download PDFInfo
- Publication number
- ZA200603597B ZA200603597B ZA200603597A ZA200603597A ZA200603597B ZA 200603597 B ZA200603597 B ZA 200603597B ZA 200603597 A ZA200603597 A ZA 200603597A ZA 200603597 A ZA200603597 A ZA 200603597A ZA 200603597 B ZA200603597 B ZA 200603597B
- Authority
- ZA
- South Africa
- Prior art keywords
- treatment
- fti
- administered
- tamoxifen
- patient
- Prior art date
Links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51782003P | 2003-11-06 | 2003-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200603597B true ZA200603597B (en) | 2007-07-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200603597A ZA200603597B (en) | 2003-11-06 | 2006-05-05 | Combination of a farnesyl transferase inhibitor with an anti-hormonal agent for the treatment of breast cancer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050119188A1 (enExample) |
| EP (1) | EP1680118A1 (enExample) |
| JP (1) | JP2007510661A (enExample) |
| CN (1) | CN1917877A (enExample) |
| AU (1) | AU2004289256A1 (enExample) |
| BR (1) | BRPI0416316A (enExample) |
| CA (1) | CA2544421A1 (enExample) |
| MX (1) | MXPA06005031A (enExample) |
| NO (1) | NO20062582L (enExample) |
| TW (1) | TW200526215A (enExample) |
| WO (1) | WO2005046691A1 (enExample) |
| ZA (1) | ZA200603597B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20060024691A1 (en) * | 2004-03-25 | 2006-02-02 | Buck Institute For Age Research | Novel pathways in the etiology of cancer |
| US20060205810A1 (en) * | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
| WO2009145852A1 (en) * | 2008-04-17 | 2009-12-03 | Concert Pharmaceuticals, Inc. | Tricyclic benzo[5,6]cyclohepta[1,2-b]pyridine derivatives and uses thereof |
| EP2266568A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of LHRH antagonists in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
| EP2266567A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874442A (en) * | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| US6096757A (en) * | 1998-12-21 | 2000-08-01 | Schering Corporation | Method for treating proliferative diseases |
| PT1255537E (pt) * | 2000-02-04 | 2006-09-29 | Janssen Pharmaceutica Nv | Inibidores da proteina farnesil transferase para tratar cancro da mama |
| US20020077301A1 (en) * | 2000-10-05 | 2002-06-20 | Whitehead Institute For Biomedical Research | Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors |
| HK1052870A1 (zh) * | 2000-10-05 | 2003-10-03 | Q. Daley George | 诱导癌细胞死亡和肿瘤消退的方法 |
| ATE415161T1 (de) * | 2001-02-15 | 2008-12-15 | Janssen Pharmaceutica Nv | Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen |
| US20030185831A1 (en) * | 2001-11-30 | 2003-10-02 | Schering Corporation | Methods of treating cancer using an FPT inhibitor and antineoplastic |
| AU2002346644A1 (en) * | 2001-12-03 | 2003-06-17 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
-
2004
- 2004-11-04 WO PCT/US2004/036859 patent/WO2005046691A1/en not_active Ceased
- 2004-11-04 US US10/980,915 patent/US20050119188A1/en not_active Abandoned
- 2004-11-04 TW TW093133659A patent/TW200526215A/zh unknown
- 2004-11-04 AU AU2004289256A patent/AU2004289256A1/en not_active Abandoned
- 2004-11-04 JP JP2006538492A patent/JP2007510661A/ja active Pending
- 2004-11-04 EP EP04810378A patent/EP1680118A1/en not_active Withdrawn
- 2004-11-04 BR BRPI0416316-8A patent/BRPI0416316A/pt not_active IP Right Cessation
- 2004-11-04 MX MXPA06005031A patent/MXPA06005031A/es unknown
- 2004-11-04 CA CA002544421A patent/CA2544421A1/en not_active Abandoned
- 2004-11-04 CN CNA2004800323958A patent/CN1917877A/zh active Pending
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2006
- 2006-05-05 ZA ZA200603597A patent/ZA200603597B/en unknown
- 2006-06-02 NO NO20062582A patent/NO20062582L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004289256A1 (en) | 2005-05-26 |
| CN1917877A (zh) | 2007-02-21 |
| CA2544421A1 (en) | 2005-05-26 |
| BRPI0416316A (pt) | 2007-01-09 |
| US20050119188A1 (en) | 2005-06-02 |
| NO20062582L (no) | 2006-08-02 |
| JP2007510661A (ja) | 2007-04-26 |
| EP1680118A1 (en) | 2006-07-19 |
| TW200526215A (en) | 2005-08-16 |
| WO2005046691A1 (en) | 2005-05-26 |
| MXPA06005031A (es) | 2006-07-06 |
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