ZA200603435B - Nucleic acids specifically binding bioactive ghrelin - Google Patents

Nucleic acids specifically binding bioactive ghrelin Download PDF

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Publication number
ZA200603435B
ZA200603435B ZA200603435A ZA200603435A ZA200603435B ZA 200603435 B ZA200603435 B ZA 200603435B ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 B ZA200603435 B ZA 200603435B
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South Africa
Prior art keywords
ghrelin
nucleic acid
bioactive
detection
nucleic
Prior art date
Application number
ZA200603435A
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English (en)
Inventor
Klussmann Sven
Helmling Steffen
Eulberg Dirk
Maasch Christian
Buchner Klaus
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Noxxon Pharma Ag
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Publication date
Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag
Publication of ZA200603435B publication Critical patent/ZA200603435B/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00Drugs for disorders of the endocrine system
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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ZA200603435A 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin ZA200603435B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025743 2003-11-10

Publications (1)

Publication Number Publication Date
ZA200603435B true ZA200603435B (en) 2007-06-27

Family

ID=34610046

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200603435A ZA200603435B (en) 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin

Country Status (19)

Country Link
US (2) US20070031840A1 (es)
EP (1) EP1682662A1 (es)
JP (1) JP4823067B2 (es)
KR (1) KR20060125743A (es)
CN (1) CN1894407A (es)
AP (1) AP2006003618A0 (es)
AU (1) AU2004291656A1 (es)
BR (1) BRPI0415872A (es)
CA (1) CA2544805A1 (es)
CR (1) CR8388A (es)
EA (1) EA009376B1 (es)
EC (1) ECSP066559A (es)
IL (1) IL175443A0 (es)
MA (1) MA28153A1 (es)
NO (1) NO20062663L (es)
OA (1) OA13282A (es)
TN (1) TNSN06132A1 (es)
WO (1) WO2005049828A1 (es)
ZA (1) ZA200603435B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4644599B2 (ja) * 2002-08-01 2011-03-02 ノクソン・フアルマ・アクチエンゲゼルシヤフト グレリン結合核酸
EP2065466B1 (en) * 2004-05-28 2014-07-09 Asuragen, Inc. Methods and compositions involving MicroRNA
EP2281889B1 (en) 2004-11-12 2014-07-30 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
UY29460A1 (es) * 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin
AU2007299828C1 (en) * 2006-09-19 2014-07-17 Interpace Diagnostics, Llc MicroRNAs differentially expressed in pancreatic diseases and uses thereof
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
CN101675165A (zh) * 2006-12-08 2010-03-17 奥斯瑞根公司 Let-7微小rna的功能和靶标
CN101622349A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-21调节的基因和途径
CA2671294A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
US20090175827A1 (en) * 2006-12-29 2009-07-09 Byrom Mike W miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
CA2689974A1 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US20090186015A1 (en) * 2007-10-18 2009-07-23 Latham Gary J Micrornas differentially expressed in lung diseases and uses thereof
US8071562B2 (en) * 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
US20090192114A1 (en) * 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
US20090263803A1 (en) * 2008-02-08 2009-10-22 Sylvie Beaudenon Mirnas differentially expressed in lymph nodes from cancer patients
EP2268832A2 (en) * 2008-03-06 2011-01-05 Asuragen, INC. Microrna markers for recurrence of colorectal cancer
EP2271757A2 (en) * 2008-03-26 2011-01-12 Asuragen, INC. Compositions and methods related to mir-16 and therapy of prostate cancer
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
US20110105389A1 (en) 2009-10-30 2011-05-05 Hoveyda Hamid R Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same
EP2663640B1 (en) * 2011-01-10 2020-11-04 APTARION biotech AG Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease

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US5614395A (en) * 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
DK0533838T3 (da) * 1990-06-11 1998-02-23 Nexstar Pharmaceuticals Inc Nukleinsyreligander
WO1996034879A1 (en) * 1995-05-03 1996-11-07 Whitehead Institute For Biomedical Research Identification of enantiomeric ligands
US5780221A (en) * 1995-05-03 1998-07-14 Whitehead Institute For Biomedical Research Identification of enantiomeric ligands
WO2001087335A2 (en) * 2000-05-17 2001-11-22 Eli Lilly And Company Method for selectively inhibiting ghrelin action
US20030211967A1 (en) * 2001-05-07 2003-11-13 Bryant Henry Uhlman Method for selectively inhibiting ghrelin action
US6967237B2 (en) * 2000-05-30 2005-11-22 Merck & Co., Inc. Ghrelin analogs
JP4644599B2 (ja) * 2002-08-01 2011-03-02 ノクソン・フアルマ・アクチエンゲゼルシヤフト グレリン結合核酸
UY29460A1 (es) * 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin

Also Published As

Publication number Publication date
OA13282A (en) 2007-01-31
US20070031840A1 (en) 2007-02-08
BRPI0415872A (pt) 2007-01-09
EA200600735A1 (ru) 2006-10-27
MA28153A1 (fr) 2006-09-01
WO2005049828A1 (en) 2005-06-02
JP4823067B2 (ja) 2011-11-24
EA009376B1 (ru) 2007-12-28
JP2007513608A (ja) 2007-05-31
TNSN06132A1 (fr) 2007-11-15
CN1894407A (zh) 2007-01-10
CA2544805A1 (en) 2005-06-02
AP2006003618A0 (en) 2006-06-30
NO20062663L (no) 2006-08-09
AU2004291656A1 (en) 2005-06-02
IL175443A0 (en) 2006-09-05
EP1682662A1 (en) 2006-07-26
US20100261291A1 (en) 2010-10-14
ECSP066559A (es) 2006-11-24
CR8388A (es) 2006-10-17
KR20060125743A (ko) 2006-12-06

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