ZA200601706B - Substituted imidazopyrimidines for the prevention and treatment of cancer - Google Patents
Substituted imidazopyrimidines for the prevention and treatment of cancer Download PDFInfo
- Publication number
- ZA200601706B ZA200601706B ZA200601706A ZA200601706A ZA200601706B ZA 200601706 B ZA200601706 B ZA 200601706B ZA 200601706 A ZA200601706 A ZA 200601706A ZA 200601706 A ZA200601706 A ZA 200601706A ZA 200601706 B ZA200601706 B ZA 200601706B
- Authority
- ZA
- South Africa
- Prior art keywords
- imidazo
- alkyl
- alpyrimidine
- pyrimidine
- methoxyphenyl
- Prior art date
Links
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- 201000011510 cancer Diseases 0.000 title claims abstract description 11
- 230000002265 prevention Effects 0.000 title description 4
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- 150000001875 compounds Chemical class 0.000 claims abstract description 40
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- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 13
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- 208000000453 Skin Neoplasms Diseases 0.000 claims description 6
- UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical compound C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 claims description 6
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- 208000015768 polyposis Diseases 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229960003010 sodium sulfate Drugs 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200301906 | 2003-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200601706B true ZA200601706B (en) | 2007-09-26 |
Family
ID=34130555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200601706A ZA200601706B (en) | 2003-07-30 | 2004-07-29 | Substituted imidazopyrimidines for the prevention and treatment of cancer |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060189631A1 (ko) |
| EP (1) | EP1660500B1 (ko) |
| JP (1) | JP2007500160A (ko) |
| KR (1) | KR20060034303A (ko) |
| CN (1) | CN1860121A (ko) |
| AT (1) | ATE380816T1 (ko) |
| AU (1) | AU2004263297A1 (ko) |
| BR (1) | BRPI0412636A (ko) |
| CA (1) | CA2534292A1 (ko) |
| DE (1) | DE602004010680T2 (ko) |
| EA (1) | EA009038B1 (ko) |
| ES (1) | ES2298798T3 (ko) |
| WO (1) | WO2005014598A1 (ko) |
| ZA (1) | ZA200601706B (ko) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007096764A2 (en) * | 2006-02-27 | 2007-08-30 | Glenmark Pharmaceuticals S.A. | Bicyclic heteroaryl derivatives as cannabinoid receptor modulators |
| WO2008021781A1 (en) | 2006-08-07 | 2008-02-21 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
| ES2689444T3 (es) | 2006-11-22 | 2018-11-14 | Incyte Holdings Corporation | Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa |
| KR20100049589A (ko) | 2007-08-14 | 2010-05-12 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 암 치료를 위한 융합된 이미다졸 |
| EP2062893A1 (en) * | 2007-10-18 | 2009-05-27 | Bayer Schering Pharma AG | Fused imidazoles for cancer treatment |
| SI2300455T1 (sl) | 2008-05-21 | 2017-12-29 | Incyte Holdings Corporation | Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo |
| MX359743B (es) | 2009-10-16 | 2018-10-08 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos para fabricar y utilizar los mismos. |
| BR112012019302B1 (pt) | 2010-02-03 | 2022-06-21 | Incyte Holdings Corporation | Imidazo[1,2-b] [1,2,4]triazinas como inibidores de c-met, composição que as compreende e métodos in vitro de inibir a atividade de c-met cinase, de inibir a via de sinalização da hgf/c-met cinase em uma célula e de inibir a atividade proliferativa de uma célula |
| US8410117B2 (en) * | 2010-03-26 | 2013-04-02 | Hoffmann-La Roche Inc. | Imidazopyrimidine derivatives |
| HUE026323T2 (en) | 2011-04-07 | 2016-05-30 | Bayer Ip Gmbh | Imidazopyridazines as AKT kinase inhibitors |
| CN102796103A (zh) * | 2011-05-23 | 2012-11-28 | 南京英派药业有限公司 | 6-（芳基甲酰）咪唑并[1,2-a]嘧啶和6-（芳基甲酰）[1,2,4]三唑并[4,3-a]嘧啶作为Hedgehog抑制剂及其应用 |
| US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9186361B2 (en) | 2013-03-15 | 2015-11-17 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| UY35400A (es) * | 2013-03-15 | 2014-10-31 | Novartis Ag | Compuestos y composiciones para el tratamiento de enfermedades parasitarias |
| SG11201604618TA (en) * | 2013-12-19 | 2016-07-28 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis |
| BR112017019349A2 (pt) | 2015-03-11 | 2018-06-05 | Melinta Therapeutics Inc | compostos antimicrobianos e métodos de fabricação e uso dos mesmos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455924A (en) * | 1967-02-08 | 1969-07-15 | Upjohn Co | Dianisylimidazoles |
| US5700826A (en) * | 1995-06-07 | 1997-12-23 | Ontogen Corporation | 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance |
| ES2140354B1 (es) * | 1998-08-03 | 2000-11-01 | S A L V A T Lab Sa | Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2. |
-
2004
- 2004-07-29 KR KR1020067001923A patent/KR20060034303A/ko not_active Application Discontinuation
- 2004-07-29 WO PCT/EP2004/008476 patent/WO2005014598A1/en active IP Right Grant
- 2004-07-29 EA EA200600330A patent/EA009038B1/ru not_active IP Right Cessation
- 2004-07-29 ZA ZA200601706A patent/ZA200601706B/en unknown
- 2004-07-29 AU AU2004263297A patent/AU2004263297A1/en not_active Abandoned
- 2004-07-29 JP JP2006521521A patent/JP2007500160A/ja not_active Withdrawn
- 2004-07-29 EP EP04763583A patent/EP1660500B1/en active Active
- 2004-07-29 BR BRPI0412636-0A patent/BRPI0412636A/pt not_active IP Right Cessation
- 2004-07-29 CA CA002534292A patent/CA2534292A1/en not_active Abandoned
- 2004-07-29 ES ES04763583T patent/ES2298798T3/es active Active
- 2004-07-29 CN CNA2004800279669A patent/CN1860121A/zh active Pending
- 2004-07-29 DE DE602004010680T patent/DE602004010680T2/de not_active Expired - Fee Related
- 2004-07-29 AT AT04763583T patent/ATE380816T1/de not_active IP Right Cessation
-
2006
- 2006-01-27 US US11/340,856 patent/US20060189631A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004010680T2 (de) | 2009-01-02 |
| ATE380816T1 (de) | 2007-12-15 |
| DE602004010680D1 (de) | 2008-01-24 |
| EA009038B1 (ru) | 2007-10-26 |
| ES2298798T3 (es) | 2008-05-16 |
| EP1660500B1 (en) | 2007-12-12 |
| EP1660500A1 (en) | 2006-05-31 |
| WO2005014598A1 (en) | 2005-02-17 |
| AU2004263297A1 (en) | 2005-02-17 |
| US20060189631A1 (en) | 2006-08-24 |
| JP2007500160A (ja) | 2007-01-11 |
| KR20060034303A (ko) | 2006-04-21 |
| CN1860121A (zh) | 2006-11-08 |
| BRPI0412636A (pt) | 2006-09-26 |
| EA200600330A1 (ru) | 2006-08-25 |
| CA2534292A1 (en) | 2005-02-17 |
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