ZA200600426B - Benzoxazinone-derived sulfonamide compounds, their preparation and use as medicaments - Google Patents
Benzoxazinone-derived sulfonamide compounds, their preparation and use as medicaments Download PDFInfo
- Publication number
- ZA200600426B ZA200600426B ZA200600426A ZA200600426A ZA200600426B ZA 200600426 B ZA200600426 B ZA 200600426B ZA 200600426 A ZA200600426 A ZA 200600426A ZA 200600426 A ZA200600426 A ZA 200600426A ZA 200600426 B ZA200600426 B ZA 200600426B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzo
- dihydro
- piperidin
- oxazin
- phenyl
- Prior art date
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- -1 sulfonamide compounds Chemical class 0.000 title claims description 1863
- 239000003814 drug Substances 0.000 title claims description 50
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical compound C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title claims description 49
- 229940124530 sulfonamide Drugs 0.000 title claims description 28
- 238000002360 preparation method Methods 0.000 title claims description 26
- 229920006395 saturated elastomer Polymers 0.000 claims description 278
- 125000002950 monocyclic group Chemical class 0.000 claims description 159
- 125000005842 heteroatom Chemical group 0.000 claims description 145
- 229910052739 hydrogen Inorganic materials 0.000 claims description 145
- 150000001875 compounds Chemical class 0.000 claims description 142
- 150000003254 radicals Chemical class 0.000 claims description 142
- 125000001424 substituent group Chemical group 0.000 claims description 122
- 125000005605 benzo group Chemical group 0.000 claims description 119
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 109
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 105
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- GZOJTRITAZODJV-UHFFFAOYSA-N 3,1-benzoxazin-2-one Chemical compound C1=CC=CC2=COC(=O)N=C21 GZOJTRITAZODJV-UHFFFAOYSA-N 0.000 claims description 41
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 15
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- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 12
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 8
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- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
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- UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 claims description 5
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- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 4
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
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- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200301812A ES2232292B1 (es) | 2003-07-30 | 2003-07-30 | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200600426B true ZA200600426B (en) | 2007-03-28 |
Family
ID=34130545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200600426A ZA200600426B (en) | 2003-07-30 | 2004-07-29 | Benzoxazinone-derived sulfonamide compounds, their preparation and use as medicaments |
Country Status (23)
Country | Link |
---|---|
US (1) | US20070032482A1 (pt) |
EP (1) | EP1648886B1 (pt) |
JP (1) | JP2007500161A (pt) |
KR (1) | KR20060056355A (pt) |
CN (1) | CN1860114A (pt) |
AR (1) | AR045153A1 (pt) |
AT (1) | ATE451366T1 (pt) |
AU (1) | AU2004263300A1 (pt) |
BR (1) | BRPI0413101A (pt) |
CA (1) | CA2534095A1 (pt) |
CL (1) | CL2004001929A1 (pt) |
DE (1) | DE602004024538D1 (pt) |
EC (1) | ECSP066331A (pt) |
ES (2) | ES2232292B1 (pt) |
IL (1) | IL173004A0 (pt) |
MX (1) | MXPA06001228A (pt) |
NO (1) | NO20060969L (pt) |
PE (1) | PE20050724A1 (pt) |
PT (1) | PT1648886E (pt) |
RU (1) | RU2006105714A (pt) |
TW (1) | TW200510354A (pt) |
WO (1) | WO2005014589A1 (pt) |
ZA (1) | ZA200600426B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007533749A (ja) * | 2004-04-20 | 2007-11-22 | アムゲン インコーポレイティッド | アリールスルホンアミドおよびそれに関連する使用方法 |
AR058277A1 (es) | 2005-12-09 | 2008-01-30 | Solvay Pharm Gmbh | N- sulfamoil - piperidin - amidas, composiciones farmaceuticas que las comprenden y procedimiento para su preparacion |
GB2435825A (en) * | 2006-03-09 | 2007-09-12 | Esteve Labor Dr | Benzimidazole-2- & pyrido[d]imidazole-2- sulphonamide derivatives for treatment of disorders mediated via 5-HT6 receptors, eg those related to food intake |
EP2053052A1 (en) | 2007-10-23 | 2009-04-29 | Laboratorios del Dr. Esteve S.A. | Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide |
WO2018009625A1 (en) | 2016-07-07 | 2018-01-11 | Bristol-Myers Squibb Company | Spirolactams as inhibitors of rock |
GB201713780D0 (en) * | 2017-08-29 | 2017-10-11 | E-Therapeutics Plc | Modulators of hedgehog (Hh) signalling pathway |
CN109232599B (zh) * | 2018-10-08 | 2021-04-20 | 广西中医药大学 | 具有抗肿瘤活性的o-对三氟甲基苯甲酰基土甘草a及其制备方法和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4344945A (en) * | 1980-03-10 | 1982-08-17 | Kyowa Hakko Kogyo Co., Ltd. | Piperidine derivatives |
TW199153B (pt) * | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
CA2166975C (en) * | 1993-07-16 | 2005-04-05 | Mark G. Bock | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists |
AU708053B2 (en) * | 1996-03-29 | 1999-07-29 | Duphar International Research B.V. | Piperazine and piperidine compounds |
ATE231846T1 (de) * | 1996-05-29 | 2003-02-15 | Warner Lambert Co | Benzoxazinone als dopamine -d4- rezeptor- antagonisten |
SE9904652D0 (sv) * | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
DK1283838T3 (da) * | 2000-05-12 | 2004-03-22 | Solvay Pharm Bv | Piperazin- og piperidinforbindelser |
-
2003
- 2003-07-30 ES ES200301812A patent/ES2232292B1/es not_active Expired - Fee Related
-
2004
- 2004-07-29 BR BRPI0413101-0A patent/BRPI0413101A/pt not_active Application Discontinuation
- 2004-07-29 CA CA002534095A patent/CA2534095A1/en not_active Abandoned
- 2004-07-29 US US10/566,404 patent/US20070032482A1/en not_active Abandoned
- 2004-07-29 RU RU2006105714/04A patent/RU2006105714A/ru unknown
- 2004-07-29 WO PCT/EP2004/008507 patent/WO2005014589A1/en active Application Filing
- 2004-07-29 CN CNA2004800280755A patent/CN1860114A/zh active Pending
- 2004-07-29 AT AT04741318T patent/ATE451366T1/de not_active IP Right Cessation
- 2004-07-29 ZA ZA200600426A patent/ZA200600426B/en unknown
- 2004-07-29 DE DE602004024538T patent/DE602004024538D1/de not_active Expired - Lifetime
- 2004-07-29 MX MXPA06001228A patent/MXPA06001228A/es active IP Right Grant
- 2004-07-29 CL CL200401929A patent/CL2004001929A1/es unknown
- 2004-07-29 AR ARP040102695A patent/AR045153A1/es unknown
- 2004-07-29 PT PT04741318T patent/PT1648886E/pt unknown
- 2004-07-29 TW TW093122663A patent/TW200510354A/zh unknown
- 2004-07-29 JP JP2006521525A patent/JP2007500161A/ja active Pending
- 2004-07-29 AU AU2004263300A patent/AU2004263300A1/en not_active Abandoned
- 2004-07-29 ES ES04741318T patent/ES2338008T3/es not_active Expired - Lifetime
- 2004-07-29 EP EP04741318A patent/EP1648886B1/en not_active Expired - Lifetime
- 2004-07-29 KR KR1020067002066A patent/KR20060056355A/ko not_active Application Discontinuation
- 2004-08-02 PE PE2004000733A patent/PE20050724A1/es not_active Application Discontinuation
-
2006
- 2006-01-05 IL IL173004A patent/IL173004A0/en unknown
- 2006-01-30 EC EC2006006331A patent/ECSP066331A/es unknown
- 2006-02-28 NO NO20060969A patent/NO20060969L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2004263300A1 (en) | 2005-02-17 |
WO2005014589A1 (en) | 2005-02-17 |
DE602004024538D1 (de) | 2010-01-21 |
CL2004001929A1 (es) | 2005-06-03 |
ATE451366T1 (de) | 2009-12-15 |
MXPA06001228A (es) | 2006-05-15 |
RU2006105714A (ru) | 2007-09-20 |
JP2007500161A (ja) | 2007-01-11 |
ECSP066331A (es) | 2006-08-30 |
CA2534095A1 (en) | 2005-01-27 |
BRPI0413101A (pt) | 2006-10-03 |
PT1648886E (pt) | 2010-03-10 |
NO20060969L (no) | 2006-04-11 |
CN1860114A (zh) | 2006-11-08 |
PE20050724A1 (es) | 2005-11-16 |
AR045153A1 (es) | 2005-10-19 |
ES2338008T3 (es) | 2010-05-03 |
KR20060056355A (ko) | 2006-05-24 |
EP1648886A1 (en) | 2006-04-26 |
TW200510354A (en) | 2005-03-16 |
ES2232292B1 (es) | 2006-11-01 |
US20070032482A1 (en) | 2007-02-08 |
EP1648886B1 (en) | 2009-12-09 |
ES2232292A1 (es) | 2005-05-16 |
IL173004A0 (en) | 2006-06-11 |
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