ZA200509661B - 9-Azabicyclo[3.3.1]non-6-ene derivatives with a heteroatom at the 3-position as renin inhibitors - Google Patents
9-Azabicyclo[3.3.1]non-6-ene derivatives with a heteroatom at the 3-position as renin inhibitorsInfo
- Publication number
- ZA200509661B ZA200509661B ZA200509661A ZA200509661A ZA200509661B ZA 200509661 B ZA200509661 B ZA 200509661B ZA 200509661 A ZA200509661 A ZA 200509661A ZA 200509661 A ZA200509661 A ZA 200509661A ZA 200509661 B ZA200509661 B ZA 200509661B
- Authority
- ZA
- South Africa
- Prior art keywords
- azabicyclo
- heteroatom
- renin inhibitors
- ene derivatives
- ene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0304492 | 2003-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200509661B true ZA200509661B (en) | 2006-11-29 |
Family
ID=33395690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200509661A ZA200509661B (en) | 2003-04-30 | 2005-11-29 | 9-Azabicyclo[3.3.1]non-6-ene derivatives with a heteroatom at the 3-position as renin inhibitors |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060258648A1 (xx) |
EP (1) | EP1622685A1 (xx) |
JP (1) | JP2006524655A (xx) |
KR (1) | KR20060008937A (xx) |
CN (1) | CN1780663A (xx) |
AU (1) | AU2004233575A1 (xx) |
BR (1) | BRPI0409884A (xx) |
CA (1) | CA2521938A1 (xx) |
MX (1) | MXPA05011498A (xx) |
NO (1) | NO20054974L (xx) |
RU (1) | RU2005137155A (xx) |
WO (1) | WO2004096366A1 (xx) |
ZA (1) | ZA200509661B (xx) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2540817A1 (en) * | 2003-10-23 | 2005-05-06 | Olivier Bezencon | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
AU2004295092A1 (en) * | 2003-12-05 | 2005-06-16 | Actelion Pharmaceuticals Ltd. | Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain |
WO2006021403A1 (en) * | 2004-08-25 | 2006-03-02 | Actelion Pharmaceuticals Ltd | Bicyclononene derivatives |
JP2008510755A (ja) | 2004-08-25 | 2008-04-10 | アクテリオン ファーマシューティカルズ リミテッド | ビシクロノネン誘導体 |
WO2006058546A1 (en) * | 2004-12-01 | 2006-06-08 | Actelion Pharmaceuticals Ltd | Novel lactame derivatives as renin inhibitors |
WO2006063610A1 (en) * | 2004-12-17 | 2006-06-22 | Actelion Pharmaceuticals Ltd | Heteroaryl substituted diazabicyclononene derivatives |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
AU2006332124B2 (en) | 2005-12-30 | 2011-03-03 | Novartis Ag | 3 , 5-substitgammaued piperidine compounds as renin inhibitors |
EP1981847A1 (en) | 2006-02-02 | 2008-10-22 | Actelion Pharmaceuticals Ltd. | Secondary amines as renin inhibitors |
WO2007104652A2 (en) * | 2006-03-16 | 2007-09-20 | Nicox S.A. | Non-peptidic renin inhibitors nitroderivatives |
WO2008141462A1 (en) | 2007-05-24 | 2008-11-27 | Merck Frosst Canada Ltd. | Novel case of renin inhibitors |
WO2009000811A1 (en) | 2007-06-25 | 2008-12-31 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
JP2010536800A (ja) | 2007-08-20 | 2010-12-02 | メルク フロスト カナダ リミテツド | レニン阻害剤 |
WO2009071449A1 (en) | 2007-12-05 | 2009-06-11 | Basf Se | Pyridylmethyl-sulfonamide compounds |
MY152042A (en) | 2008-05-05 | 2014-08-15 | Actelion Pharmaceuticals Ltd | 3,4- substituted piperidine derivatives as renin inhibitors |
ATE540957T1 (de) * | 2008-11-25 | 2012-01-15 | Univ Firenze | Bicyclische peptidomimetikum-inhibitoren von aspartylproteasen zur behandlung von infektionskrankheiten |
CN102093389B (zh) * | 2009-12-09 | 2014-11-19 | 华东理工大学 | 双联和氧桥杂环新烟碱化合物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3509161A (en) * | 1967-07-10 | 1970-04-28 | Boehringer & Soehne Gmbh | 3-phenyl-granatene-(2)-derivatives |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
CN1256326C (zh) * | 1995-09-07 | 2006-05-17 | 弗·哈夫曼-拉罗切有限公司 | 治疗心脏和肾功能不全的新型4-(氧烷氧基苯基)-3-氧哌啶化合物 |
BR0309498A (pt) * | 2002-04-29 | 2005-02-15 | Actelion Pharmaceuticals Ltd | Compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças que são relacionadas com o ras, e, uso de compostos |
AU2003229746A1 (en) * | 2002-06-27 | 2004-01-19 | Actelion Pharmaceuticals Ltd | Novel tetrahydropyridine derivatives as renin inhibitors |
-
2004
- 2004-04-26 WO PCT/EP2004/004371 patent/WO2004096366A1/en active Application Filing
- 2004-04-26 CA CA002521938A patent/CA2521938A1/en not_active Abandoned
- 2004-04-26 US US10/554,702 patent/US20060258648A1/en not_active Abandoned
- 2004-04-26 RU RU2005137155/04A patent/RU2005137155A/ru not_active Application Discontinuation
- 2004-04-26 CN CNA2004800116375A patent/CN1780663A/zh active Pending
- 2004-04-26 AU AU2004233575A patent/AU2004233575A1/en not_active Abandoned
- 2004-04-26 JP JP2006505260A patent/JP2006524655A/ja active Pending
- 2004-04-26 BR BRPI0409884-6A patent/BRPI0409884A/pt not_active Application Discontinuation
- 2004-04-26 KR KR1020057020489A patent/KR20060008937A/ko not_active Application Discontinuation
- 2004-04-26 EP EP04729430A patent/EP1622685A1/en not_active Withdrawn
- 2004-04-26 MX MXPA05011498A patent/MXPA05011498A/es unknown
-
2005
- 2005-10-26 NO NO20054974A patent/NO20054974L/no not_active Application Discontinuation
- 2005-11-29 ZA ZA200509661A patent/ZA200509661B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2521938A1 (en) | 2004-11-11 |
EP1622685A1 (en) | 2006-02-08 |
NO20054974D0 (no) | 2005-10-26 |
AU2004233575A1 (en) | 2004-11-11 |
US20060258648A1 (en) | 2006-11-16 |
WO2004096366A1 (en) | 2004-11-11 |
KR20060008937A (ko) | 2006-01-27 |
BRPI0409884A (pt) | 2006-05-23 |
NO20054974L (no) | 2005-11-28 |
JP2006524655A (ja) | 2006-11-02 |
MXPA05011498A (es) | 2005-12-15 |
RU2005137155A (ru) | 2006-03-27 |
CN1780663A (zh) | 2006-05-31 |
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