ZA200507205B - Fast dissolving orally consumable films containing a modified starch for improved heat and moisture resistance - Google Patents
Fast dissolving orally consumable films containing a modified starch for improved heat and moisture resistance Download PDFInfo
- Publication number
- ZA200507205B ZA200507205B ZA200507205A ZA200507205A ZA200507205B ZA 200507205 B ZA200507205 B ZA 200507205B ZA 200507205 A ZA200507205 A ZA 200507205A ZA 200507205 A ZA200507205 A ZA 200507205A ZA 200507205 B ZA200507205 B ZA 200507205B
- Authority
- ZA
- South Africa
- Prior art keywords
- starches
- consumable film
- modified starch
- film
- modified
- Prior art date
Links
- 229920000881 Modified starch Polymers 0.000 title claims description 43
- 235000019426 modified starch Nutrition 0.000 title claims description 38
- 239000004368 Modified starch Substances 0.000 title claims description 24
- 239000013543 active substance Substances 0.000 claims description 29
- 229920002472 Starch Polymers 0.000 claims description 23
- 235000019698 starch Nutrition 0.000 claims description 23
- 210000000214 mouth Anatomy 0.000 claims description 11
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- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229960000938 nalorphine Drugs 0.000 description 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 1
- 229960004127 naloxone Drugs 0.000 description 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 1
- 229960003086 naltrexone Drugs 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- 229960001597 nifedipine Drugs 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 229960005118 oxymorphone Drugs 0.000 description 1
- 229960003396 phenacemide Drugs 0.000 description 1
- 229960003893 phenacetin Drugs 0.000 description 1
- 229960000964 phenelzine Drugs 0.000 description 1
- 229960003877 pheneturide Drugs 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 229960004227 phensuximide Drugs 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- VJKUPQSHOVKBCO-AHMKVGDJSA-N picrotoxin Chemical compound O=C([C@@]12O[C@@H]1C[C@]1(O)[C@@]32C)O[C@@H]3[C@H]2[C@@H](C(=C)C)[C@@H]1C(=O)O2.O=C([C@@]12O[C@@H]1C[C@]1(O)[C@@]32C)O[C@@H]3[C@H]2[C@@H](C(C)(O)C)[C@@H]1C(=O)O2 VJKUPQSHOVKBCO-AHMKVGDJSA-N 0.000 description 1
- 229960004839 potassium iodide Drugs 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 description 1
- 229960002393 primidone Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
- 229960003908 pseudoephedrine Drugs 0.000 description 1
- 230000001003 psychopharmacologic effect Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940084560 sanguinarine Drugs 0.000 description 1
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229960002573 sultiame Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- RBNWAMSGVWEHFP-WAAGHKOSSA-N terpin Chemical compound CC(C)(O)[C@H]1CC[C@@](C)(O)CC1 RBNWAMSGVWEHFP-WAAGHKOSSA-N 0.000 description 1
- 229950010257 terpin Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 229960003741 tranylcypromine Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- IRYJRGCIQBGHIV-UHFFFAOYSA-N trimethadione Chemical compound CN1C(=O)OC(C)(C)C1=O IRYJRGCIQBGHIV-UHFFFAOYSA-N 0.000 description 1
- 229960004453 trimethadione Drugs 0.000 description 1
- 229960001593 triprolidine hydrochloride Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- 229960001360 zolmitriptan Drugs 0.000 description 1
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Grain Derivatives (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Dental Preparations (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46733903P | 2003-05-02 | 2003-05-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200507205B true ZA200507205B (en) | 2006-11-29 |
Family
ID=33418443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200507205A ZA200507205B (en) | 2003-05-02 | 2005-09-07 | Fast dissolving orally consumable films containing a modified starch for improved heat and moisture resistance |
Country Status (19)
Country | Link |
---|---|
US (1) | US20040247648A1 (es) |
EP (1) | EP1622595A1 (es) |
JP (1) | JP2006525308A (es) |
CN (1) | CN1784218A (es) |
AR (1) | AR044131A1 (es) |
AU (1) | AU2004233744A1 (es) |
BR (1) | BRPI0409463A (es) |
CA (1) | CA2523372A1 (es) |
CL (1) | CL2004000931A1 (es) |
CO (1) | CO5640073A2 (es) |
GT (1) | GT200400085A (es) |
MX (1) | MXPA05010422A (es) |
PA (1) | PA8601801A1 (es) |
PE (1) | PE20050175A1 (es) |
RU (1) | RU2005129309A (es) |
TW (1) | TW200503786A (es) |
UY (1) | UY28304A1 (es) |
WO (1) | WO2004096193A1 (es) |
ZA (1) | ZA200507205B (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040131662A1 (en) | 2003-11-12 | 2004-07-08 | Davidson Robert S. | Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films |
US8999372B2 (en) * | 2002-11-14 | 2015-04-07 | Cure Pharmaceutical Corporation | Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use |
US9561182B2 (en) * | 2003-08-22 | 2017-02-07 | Cure Pharmaceutical Corporation | Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals |
US20040191302A1 (en) | 2003-03-28 | 2004-09-30 | Davidson Robert S. | Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films |
WO2005046363A2 (en) | 2003-11-07 | 2005-05-26 | U.S. Smokeless Tobacco Company | Tobacco compositions |
US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
DE102004002951A1 (de) * | 2004-01-21 | 2005-08-11 | Wella Ag | Verfahren zur Herstellung haarfestigender Produkte in Folienform |
US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
ES2704482T3 (es) | 2004-11-24 | 2019-03-18 | Meda Pharmaceuticals Inc | Composiciones que comprenden azelastina y sus métodos de uso |
CA2612179C (en) * | 2005-06-17 | 2016-08-02 | Aft Pharmaceuticals Limited | A pharmaceutical composition comprising loratadine and its use to treat patients with upper respiratory mucosal congestion |
DE102005033943A1 (de) * | 2005-07-20 | 2007-02-22 | Hexal Ag | Nicht-ausspuckbarer, oraler, schnell-zerfallender Film für ein Neuroleptikum |
US20070098746A1 (en) * | 2005-11-02 | 2007-05-03 | Nichols William M | Multi-layered coating technology for taste masking |
IL175338A0 (en) * | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
TW200816985A (en) * | 2006-06-05 | 2008-04-16 | Verus Pharmaceuticals Inc | Methods for buccal, lingual or sublingual dosing regimens of epinephrine for the treatment of allergic emergencies |
WO2007143676A2 (en) * | 2006-06-05 | 2007-12-13 | Verus Pharmaceuticals, Inc. | Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms |
US20070292481A1 (en) * | 2006-06-16 | 2007-12-20 | Hoffman Andrew J | Packaging of Food Products with Pullulan Films |
US20080152761A1 (en) * | 2006-12-20 | 2008-06-26 | Shiji Shen | Packaging of Food Products with Pullulan Films |
US20070298078A1 (en) * | 2006-06-27 | 2007-12-27 | Harrison Michael D | Water Soluble Article for Imparting Dietary Fiber to Bottled Water |
DE102006061287A1 (de) * | 2006-12-22 | 2008-06-26 | Lts Lohmann Therapie-Systeme Ag | Eßbare folienförmige Zubereitung mit Cola-Geschmack |
US20090011115A1 (en) * | 2007-03-13 | 2009-01-08 | Foss Carter D | Edible Pullulan Films Containing Flavoring |
US20080274252A1 (en) * | 2007-04-12 | 2008-11-06 | Hoffman Andrew J | Pullulan film containing sweetener |
US20090004254A1 (en) * | 2007-06-19 | 2009-01-01 | Todd Maibach | Film comprising active drugs |
BRPI0821608A2 (pt) * | 2007-12-11 | 2015-09-29 | Novartis Ag | filmes de multizona |
US20110114657A1 (en) * | 2009-11-13 | 2011-05-19 | Nygaard Leann M | Beverage container holder and edible film package assembly |
JP2012031164A (ja) * | 2010-07-06 | 2012-02-16 | Teika Seiyaku Kk | フィルム状製剤 |
CN108434089B (zh) * | 2010-10-08 | 2020-06-16 | R·P·舍勒科技有限责任公司 | 使用淀粉的口服疫苗快速溶解剂型 |
US20130052234A1 (en) * | 2011-08-25 | 2013-02-28 | Purebrands LLC | Edible strips |
CN102836144A (zh) * | 2012-09-28 | 2012-12-26 | 天津市聚星康华医药科技有限公司 | 一种去氧肾上腺素口腔速溶膜及其制备方法 |
BR112016002205A2 (pt) | 2013-07-31 | 2017-08-01 | Bluepharma Ind Farmaceutica S A | filmes orodispersíveis |
CN104530489B (zh) * | 2015-02-05 | 2017-07-07 | 湖南尔康制药股份有限公司 | 一种速溶于水的淀粉成膜组合物 |
EP3061501A1 (en) | 2015-02-27 | 2016-08-31 | Rottapharm Ltd. | Composition for the treatment of acne |
CN104983732B (zh) * | 2015-05-28 | 2018-05-04 | 华润三九医药股份有限公司 | 一种布洛肾素那敏片及其制备方法 |
EP3117825A1 (en) | 2015-07-16 | 2017-01-18 | Rottapharm S.p.A. | Oral formulation comprising berberine and morus alba extract |
WO2017141104A2 (en) * | 2016-02-18 | 2017-08-24 | Immune Therapeutics, Inc. | Method for inducing a sustained immune response |
CA3075271C (en) | 2017-09-08 | 2021-10-12 | Insignis Therapeutics, Inc. | Methods of using dipivefrin |
CN113613630A (zh) | 2019-03-01 | 2021-11-05 | 因斯格尼斯疗法有限公司 | 地匹福林口腔崩解片剂制剂 |
KR102221453B1 (ko) * | 2019-07-19 | 2021-03-02 | 한국프라임제약주식회사 | 저분자 콜라겐 펩타이드 및 천연추출복합물을 포함하는 구강점막부착형 필름 조성물 및 이를 이용하여 제조된 구강점막부착형 필름 |
CN117653610B (zh) * | 2023-09-28 | 2024-07-05 | 海南卓科制药有限公司 | 一种硝酸甘油片及其制备方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1142325A (en) * | 1965-05-14 | 1969-02-05 | Higham Stanley Russell | Means for administering drugs |
US4197289A (en) * | 1975-12-15 | 1980-04-08 | Hoffmann-La Roche Inc. | Novel dosage forms |
US4562020A (en) * | 1982-12-11 | 1985-12-31 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for producing self-supporting glucan film |
JPS60219238A (ja) * | 1984-04-14 | 1985-11-01 | Hayashibara Biochem Lab Inc | 徐崩性プルラン含有成形物とその製法 |
DE3630603A1 (de) * | 1986-09-09 | 1988-03-10 | Desitin Arzneimittel Gmbh | Darreichungs- und dosierungsform fuer arzneimittelwirkstoffe, reagentien oder dergleichen sowie verfahren zu deren herstellung |
JPH0739508B2 (ja) * | 1986-11-11 | 1995-05-01 | 株式会社林原生物化学研究所 | プルラン・ポリエチレングリコ−ル会合物とその製造方法並びに用途 |
US5047244A (en) * | 1988-06-03 | 1991-09-10 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
US5354551A (en) * | 1989-10-14 | 1994-10-11 | Desitin Arzneimittel Gmbh | Oral and dental hygiene preparation |
DE4018247A1 (de) * | 1990-06-07 | 1991-12-12 | Lohmann Therapie Syst Lts | Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen |
JP3232488B2 (ja) * | 1992-08-20 | 2001-11-26 | 株式会社林原生物化学研究所 | プルラン高含有物とその製造方法並びに用途 |
US5411945A (en) * | 1992-08-29 | 1995-05-02 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Pullulan binder and its uses |
US20030211136A1 (en) * | 1998-09-25 | 2003-11-13 | Neema Kulkarni | Fast dissolving orally consumable films containing a sweetener |
US7067116B1 (en) * | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
US20020131990A1 (en) * | 2000-11-30 | 2002-09-19 | Barkalow David G. | Pullulan free edible film compositions and methods of making the same |
US6660292B2 (en) * | 2001-06-19 | 2003-12-09 | Hf Flavoring Technology Llp | Rapidly disintegrating flavored film for precooked foods |
WO2003003957A1 (en) * | 2001-07-06 | 2003-01-16 | Lavipharm Laboratories Inc. | Quick dissolving oral mucosal drug delivery device with moisture barrier coating |
US6656493B2 (en) * | 2001-07-30 | 2003-12-02 | Wm. Wrigley Jr. Company | Edible film formulations containing maltodextrin |
AU2002362772B2 (en) * | 2001-10-12 | 2007-09-06 | Aquestive Therapeutics, Inc. | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
EP1463490B1 (en) * | 2001-10-12 | 2011-12-14 | MonoSolRX, LLC | Glucan based film delivery systems |
MXPA02011337A (es) * | 2001-11-16 | 2003-05-26 | Nat Starch Chem Invest | Peliculas que contienen almidon. |
US20030099691A1 (en) * | 2001-11-16 | 2003-05-29 | Susan Lydzinski | Films containing starch |
-
2004
- 2004-04-19 EP EP04728218A patent/EP1622595A1/en not_active Withdrawn
- 2004-04-19 MX MXPA05010422A patent/MXPA05010422A/es unknown
- 2004-04-19 AU AU2004233744A patent/AU2004233744A1/en not_active Abandoned
- 2004-04-19 JP JP2006506579A patent/JP2006525308A/ja active Pending
- 2004-04-19 BR BRPI0409463-8A patent/BRPI0409463A/pt not_active IP Right Cessation
- 2004-04-19 CA CA002523372A patent/CA2523372A1/en not_active Abandoned
- 2004-04-19 CN CNA2004800118883A patent/CN1784218A/zh active Pending
- 2004-04-19 WO PCT/IB2004/001398 patent/WO2004096193A1/en active Application Filing
- 2004-04-19 RU RU2005129309/15A patent/RU2005129309A/ru not_active Application Discontinuation
- 2004-04-29 AR ARP040101464A patent/AR044131A1/es unknown
- 2004-04-29 TW TW093111967A patent/TW200503786A/zh unknown
- 2004-04-29 GT GT200400085A patent/GT200400085A/es unknown
- 2004-04-29 PE PE2004000428A patent/PE20050175A1/es not_active Application Discontinuation
- 2004-04-30 CL CL200400931A patent/CL2004000931A1/es unknown
- 2004-04-30 PA PA20048601801A patent/PA8601801A1/es unknown
- 2004-04-30 UY UY28304A patent/UY28304A1/es not_active Application Discontinuation
- 2004-05-03 US US10/838,045 patent/US20040247648A1/en not_active Abandoned
-
2005
- 2005-09-07 ZA ZA200507205A patent/ZA200507205B/en unknown
- 2005-10-28 CO CO05110248A patent/CO5640073A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0409463A (pt) | 2006-05-02 |
PA8601801A1 (es) | 2004-11-26 |
AR044131A1 (es) | 2005-08-24 |
CO5640073A2 (es) | 2006-05-31 |
WO2004096193A1 (en) | 2004-11-11 |
AU2004233744A1 (en) | 2004-11-11 |
CN1784218A (zh) | 2006-06-07 |
TW200503786A (en) | 2005-02-01 |
RU2005129309A (ru) | 2006-05-10 |
EP1622595A1 (en) | 2006-02-08 |
GT200400085A (es) | 2005-03-03 |
CA2523372A1 (en) | 2004-11-11 |
US20040247648A1 (en) | 2004-12-09 |
MXPA05010422A (es) | 2005-11-04 |
JP2006525308A (ja) | 2006-11-09 |
UY28304A1 (es) | 2004-11-30 |
PE20050175A1 (es) | 2005-03-21 |
CL2004000931A1 (es) | 2005-01-07 |
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