ZA200506710B - Formulations comprising tolterodine and cocoa powder and use thereof - Google Patents
Formulations comprising tolterodine and cocoa powder and use thereof Download PDFInfo
- Publication number
- ZA200506710B ZA200506710B ZA200506710A ZA200506710A ZA200506710B ZA 200506710 B ZA200506710 B ZA 200506710B ZA 200506710 A ZA200506710 A ZA 200506710A ZA 200506710 A ZA200506710 A ZA 200506710A ZA 200506710 B ZA200506710 B ZA 200506710B
- Authority
- ZA
- South Africa
- Prior art keywords
- formulation according
- oil
- tolterodine
- cocoa butter
- chosen
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 68
- 238000009472 formulation Methods 0.000 title claims description 52
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 title claims description 45
- 229960004045 tolterodine Drugs 0.000 title claims description 42
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 title claims description 42
- 235000009470 Theobroma cacao Nutrition 0.000 title claims description 25
- 239000000843 powder Substances 0.000 title claims description 23
- 244000240602 cacao Species 0.000 title 1
- 244000299461 Theobroma cacao Species 0.000 claims description 27
- 206010020853 Hypertonic bladder Diseases 0.000 claims description 22
- 239000004615 ingredient Substances 0.000 claims description 18
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 16
- 208000020629 overactive bladder Diseases 0.000 claims description 16
- 239000003925 fat Substances 0.000 claims description 14
- 235000019197 fats Nutrition 0.000 claims description 14
- 239000002207 metabolite Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
- -1 aspartarne Chemical compound 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 10
- 150000002632 lipids Chemical class 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 239000000651 prodrug Substances 0.000 claims description 10
- 229940002612 prodrug Drugs 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000006172 buffering agent Substances 0.000 claims description 8
- 235000019877 cocoa butter equivalent Nutrition 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- 244000105624 Arachis hypogaea Species 0.000 claims description 6
- 235000019878 cocoa butter replacer Nutrition 0.000 claims description 6
- 235000019879 cocoa butter substitute Nutrition 0.000 claims description 6
- 239000008173 hydrogenated soybean oil Substances 0.000 claims description 5
- 210000000214 mouth Anatomy 0.000 claims description 5
- 239000008371 vanilla flavor Substances 0.000 claims description 5
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims description 4
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 235000019486 Sunflower oil Nutrition 0.000 claims description 4
- 235000014121 butter Nutrition 0.000 claims description 4
- 235000019868 cocoa butter Nutrition 0.000 claims description 4
- 229940110456 cocoa butter Drugs 0.000 claims description 4
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- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
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- 235000011187 glycerol Nutrition 0.000 claims description 4
- 235000010445 lecithin Nutrition 0.000 claims description 4
- 239000000787 lecithin Substances 0.000 claims description 4
- 229940067606 lecithin Drugs 0.000 claims description 4
- 235000021313 oleic acid Nutrition 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- 229940073732 polyglycerol polyricinoleic acid Drugs 0.000 claims description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000008347 soybean phospholipid Substances 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 239000002600 sunflower oil Substances 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
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- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 3
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- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000008368 mint flavor Substances 0.000 claims description 3
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- 239000001195 (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid Substances 0.000 claims description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 235000003276 Apios tuberosa Nutrition 0.000 claims description 2
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- 235000010744 Arachis villosulicarpa Nutrition 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
- 235000004936 Bromus mango Nutrition 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims description 2
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- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 2
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- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 2
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
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Landscapes
- Health & Medical Sciences (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0300830A SE0300830D0 (sv) | 2003-03-26 | 2003-03-26 | New formulations and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200506710B true ZA200506710B (en) | 2006-11-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ZA200506710A ZA200506710B (en) | 2003-03-26 | 2005-08-22 | Formulations comprising tolterodine and cocoa powder and use thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1605920A1 (es) |
| JP (1) | JP2006521347A (es) |
| CN (1) | CN1764441A (es) |
| AR (1) | AR043773A1 (es) |
| AU (1) | AU2004224556A1 (es) |
| BR (1) | BRPI0408743A (es) |
| CA (1) | CA2519119A1 (es) |
| CL (1) | CL2004000625A1 (es) |
| MX (1) | MXPA05010314A (es) |
| SE (1) | SE0300830D0 (es) |
| WO (1) | WO2004084864A1 (es) |
| ZA (1) | ZA200506710B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1907136B (zh) * | 2006-07-28 | 2010-08-25 | 张新生 | 植物保健乳及其加工方法 |
| CA2689079C (en) | 2007-06-13 | 2016-01-05 | Otsuka Pharmaceutical Co., Ltd. | Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food |
| JP5702926B2 (ja) | 2009-10-16 | 2015-04-15 | 東レ・ダウコーニング株式会社 | 拭取り紙用処理剤組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB918955A (en) * | 1960-05-19 | 1963-02-20 | Thomae Gmbh Dr K | Pharmaceutical laxative compositions comprising 4,4-dihydroxy-2-amino triphenylmethane |
| SE9803986D0 (sv) * | 1998-11-23 | 1998-11-23 | Pharmacia & Upjohn Ab | New compositions |
| JP2001114668A (ja) * | 1999-10-13 | 2001-04-24 | Meiji Seika Kaisha Ltd | チョコレート剤 |
| CA2387973C (en) * | 1999-11-11 | 2009-12-22 | Pharmacia Ab | Pharmaceutical formulation containing tolterodine and its use |
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2003
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2004
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- 2004-03-16 JP JP2006506376A patent/JP2006521347A/ja active Pending
- 2004-03-16 CA CA002519119A patent/CA2519119A1/en not_active Abandoned
- 2004-03-16 MX MXPA05010314A patent/MXPA05010314A/es not_active Application Discontinuation
- 2004-03-16 EP EP04720944A patent/EP1605920A1/en not_active Withdrawn
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2005
- 2005-08-22 ZA ZA200506710A patent/ZA200506710B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004084864A1 (en) | 2004-10-07 |
| EP1605920A1 (en) | 2005-12-21 |
| AU2004224556A1 (en) | 2004-10-07 |
| SE0300830D0 (sv) | 2003-03-26 |
| MXPA05010314A (es) | 2006-05-19 |
| JP2006521347A (ja) | 2006-09-21 |
| CN1764441A (zh) | 2006-04-26 |
| AR043773A1 (es) | 2005-08-10 |
| CA2519119A1 (en) | 2004-10-07 |
| BRPI0408743A (pt) | 2006-03-28 |
| CL2004000625A1 (es) | 2005-01-07 |
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