ZA200506614B - 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases - Google Patents
1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases Download PDFInfo
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- ZA200506614B ZA200506614B ZA200506614A ZA200506614A ZA200506614B ZA 200506614 B ZA200506614 B ZA 200506614B ZA 200506614 A ZA200506614 A ZA 200506614A ZA 200506614 A ZA200506614 A ZA 200506614A ZA 200506614 B ZA200506614 B ZA 200506614B
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- South Africa
- Prior art keywords
- compounds
- chf
- alkyl
- branched
- linear
- Prior art date
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- 208000015122 neurodegenerative disease Diseases 0.000 title claims description 7
- 230000004770 neurodegeneration Effects 0.000 title claims description 5
- 239000002253 acid Substances 0.000 title description 9
- 150000001875 compounds Chemical class 0.000 claims description 43
- 125000000217 alkyl group Chemical group 0.000 claims description 28
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 229910052731 fluorine Inorganic materials 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
- 239000011737 fluorine Substances 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 15
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 208000024827 Alzheimer disease Diseases 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
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- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 claims description 5
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
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- IYYZUPMFVPLQIF-UHFFFAOYSA-N dibenzothiophene Chemical compound C1=CC=C2C3=CC=CC=C3SC2=C1 IYYZUPMFVPLQIF-UHFFFAOYSA-N 0.000 claims description 4
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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|---|---|---|---|
| ITMI20030311 ITMI20030311A1 (it) | 2003-02-21 | 2003-02-21 | Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer. |
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| ZA200506614B true ZA200506614B (en) | 2006-12-27 |
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| CN (2) | CN100398506C (zh) |
| IT (1) | ITMI20030311A1 (zh) |
| ZA (1) | ZA200506614B (zh) |
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| EP2133322A1 (en) * | 2008-06-11 | 2009-12-16 | CHIESI FARMACEUTICI S.p.A. | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
| CN102596879B (zh) * | 2009-08-04 | 2015-01-28 | 奇斯药制品公司 | 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法 |
| CN102869643A (zh) * | 2010-04-01 | 2013-01-09 | 奇斯药制品公司 | 新的多晶型物和盐 |
| CN105658615A (zh) * | 2013-06-24 | 2016-06-08 | 奇斯药制品公司 | 用于制备1-(2-氟[1,1′-联苯]-4-基)-环丙烷甲酸衍生物的改进方法 |
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| JPS4994680A (zh) * | 1973-01-22 | 1974-09-09 | ||
| JPS5046669A (zh) * | 1973-03-28 | 1975-04-25 | ||
| GB1442707A (en) * | 1973-07-07 | 1976-07-14 | Yoshitomi Pharmaceutical | Substituted phenylalkanoic acids and their derivatives and pharma ceutical compositions thereof |
| JPS58177977A (ja) * | 1982-04-09 | 1983-10-18 | Grelan Pharmaceut Co Ltd | ４−フエニルピラゾ−ル類 |
| US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
| DE10123884A1 (de) * | 2001-05-16 | 2002-11-21 | Bayer Ag | Herstellung und Verwendung von Palladium-Katalysatoren für Kreuzkupplungsreaktionen |
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| CN100398506C (zh) | 2008-07-02 |
| CN101328117B (zh) | 2014-04-23 |
| ITMI20030311A1 (it) | 2004-08-22 |
| CN1751018A (zh) | 2006-03-22 |
| CN101328117A (zh) | 2008-12-24 |
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