ZA200506459B - S-[2[(1-iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt - Google Patents

S-[2[(1-iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt Download PDF

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Publication number
ZA200506459B
ZA200506459B ZA200506459A ZA200506459A ZA200506459B ZA 200506459 B ZA200506459 B ZA 200506459B ZA 200506459 A ZA200506459 A ZA 200506459A ZA 200506459 A ZA200506459 A ZA 200506459A ZA 200506459 B ZA200506459 B ZA 200506459B
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South Africa
Prior art keywords
methyl
ethyl
iminoethyl
amino
cysteine
Prior art date
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ZA200506459A
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English (en)
Inventor
Sheikh Ahmad
Brostrom Lyle Robinson
Ann M Czyzewski
Zia Vahid
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Pharmacia Corp
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Publication of ZA200506459B publication Critical patent/ZA200506459B/en

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    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • AHUMAN NECESSITIES
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26Separation; Purification; Stabilisation; Use of additives
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    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
ZA200506459A 2003-03-11 2005-08-11 S-[2[(1-iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt ZA200506459B (en)

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Application Number Priority Date Filing Date Title
US45349603P 2003-03-11 2003-03-11

Publications (1)

Publication Number Publication Date
ZA200506459B true ZA200506459B (en) 2006-11-29

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ZA200506459A ZA200506459B (en) 2003-03-11 2005-08-11 S-[2[(1-iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt

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US (2) US20050038120A1 (pt)
EP (1) EP1603872B1 (pt)
JP (1) JP4794433B2 (pt)
KR (2) KR100927911B1 (pt)
CN (1) CN100460387C (pt)
AR (1) AR043521A1 (pt)
AT (1) ATE509909T1 (pt)
AU (1) AU2004220266B2 (pt)
BR (1) BRPI0408226A (pt)
CA (1) CA2518745C (pt)
CL (1) CL2004000472A1 (pt)
CO (1) CO5611122A2 (pt)
CY (1) CY1112461T1 (pt)
DK (1) DK1603872T3 (pt)
ES (1) ES2363001T3 (pt)
GT (1) GT200400040A (pt)
HK (1) HK1088301A1 (pt)
IL (1) IL170554A (pt)
MX (1) MXPA05008674A (pt)
NL (1) NL1025691C2 (pt)
NO (1) NO20054645L (pt)
NZ (1) NZ574218A (pt)
PA (1) PA8597701A1 (pt)
PE (1) PE20050309A1 (pt)
PL (1) PL1603872T3 (pt)
PT (1) PT1603872E (pt)
RU (1) RU2357953C2 (pt)
SG (1) SG155782A1 (pt)
SI (1) SI1603872T1 (pt)
TW (1) TWI352076B (pt)
UY (1) UY28229A1 (pt)
WO (1) WO2004080956A1 (pt)
ZA (1) ZA200506459B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6094101A (en) * 1999-03-17 2000-07-25 Tropian, Inc. Direct digital frequency synthesis enabling spur elimination
PT1793187E (pt) * 2004-09-21 2012-03-05 Joan Vives Iglesias Processo e máquina destinados à sinterização e/ou secagem de materiais em pó utilizando uma radiação infravermelha

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU692892B2 (en) * 1994-06-15 1998-06-18 Wellcome Foundation Limited, The Enzyme inhibitors
NZ542734A (en) * 2000-03-24 2007-06-29 Pharmacia Corp Use of amidino compounds as nitric oxide synthase inhibitors for treating arthritis
AR031609A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa

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Publication number Publication date
CA2518745A1 (en) 2004-09-23
BRPI0408226A (pt) 2006-03-01
IL170554A (en) 2011-10-31
AR043521A1 (es) 2005-08-03
EP1603872B1 (en) 2011-05-18
SI1603872T1 (sl) 2011-07-29
DK1603872T3 (da) 2011-07-18
ES2363001T3 (es) 2011-07-18
PA8597701A1 (es) 2005-02-04
WO2004080956A1 (en) 2004-09-23
GT200400040A (es) 2005-01-14
HK1088301A1 (en) 2006-11-03
KR100927911B1 (ko) 2009-11-19
AU2004220266B2 (en) 2010-08-19
CO5611122A2 (es) 2006-02-28
SG155782A1 (en) 2009-10-29
KR20050107617A (ko) 2005-11-14
PT1603872E (pt) 2011-06-07
TW200508185A (en) 2005-03-01
US7767850B2 (en) 2010-08-03
CN100460387C (zh) 2009-02-11
AU2004220266A1 (en) 2004-09-23
JP4794433B2 (ja) 2011-10-19
RU2357953C2 (ru) 2009-06-10
KR20090048521A (ko) 2009-05-13
ATE509909T1 (de) 2011-06-15
US20050038120A1 (en) 2005-02-17
EP1603872A1 (en) 2005-12-14
RU2005125833A (ru) 2006-05-10
NO20054645L (no) 2005-11-25
NZ574218A (en) 2009-11-27
PE20050309A1 (es) 2005-05-04
TWI352076B (en) 2011-11-11
UY28229A1 (es) 2004-11-08
US20090215891A1 (en) 2009-08-27
CN1787993A (zh) 2006-06-14
JP2006519838A (ja) 2006-08-31
MXPA05008674A (es) 2005-10-18
CY1112461T1 (el) 2015-12-09
CA2518745C (en) 2010-10-19
NO20054645D0 (no) 2005-10-10
PL1603872T3 (pl) 2011-09-30
NL1025691A1 (nl) 2004-09-14
NL1025691C2 (nl) 2006-06-30
CL2004000472A1 (es) 2005-05-13

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