ZA200408027B - Isoquinoline derivatives. - Google Patents
Isoquinoline derivatives. Download PDFInfo
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- ZA200408027B ZA200408027B ZA200408027A ZA200408027A ZA200408027B ZA 200408027 B ZA200408027 B ZA 200408027B ZA 200408027 A ZA200408027 A ZA 200408027A ZA 200408027 A ZA200408027 A ZA 200408027A ZA 200408027 B ZA200408027 B ZA 200408027B
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- South Africa
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- compounds
- compound
- solvates
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- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
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- -1 4-methylpyridin-2-yl Chemical group 0.000 claims description 39
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims description 4
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- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000006384 methylpyridyl group Chemical group 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 description 1
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- VWBWQOUWDOULQN-UHFFFAOYSA-N nmp n-methylpyrrolidone Chemical compound CN1CCCC1=O.CN1CCCC1=O VWBWQOUWDOULQN-UHFFFAOYSA-N 0.000 description 1
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- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 201000003068 rheumatic fever Diseases 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 102000027257 transmembrane receptors Human genes 0.000 description 1
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10209692A DE10209692A1 (de) | 2002-03-06 | 2002-03-06 | Isochinolinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200408027B true ZA200408027B (en) | 2005-07-05 |
Family
ID=27762712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200408027A ZA200408027B (en) | 2002-03-06 | 2004-10-05 | Isoquinoline derivatives. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7060707B2 (de) |
| EP (1) | EP1480971A1 (de) |
| JP (1) | JP2005525363A (de) |
| KR (1) | KR20040089704A (de) |
| CN (1) | CN1639150A (de) |
| AR (1) | AR038869A1 (de) |
| AU (1) | AU2003218980A1 (de) |
| BR (1) | BR0308195A (de) |
| CA (1) | CA2478618A1 (de) |
| DE (1) | DE10209692A1 (de) |
| MX (1) | MXPA04008469A (de) |
| PL (1) | PL371216A1 (de) |
| RU (1) | RU2004129734A (de) |
| WO (1) | WO2003074512A1 (de) |
| ZA (1) | ZA200408027B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101360736A (zh) * | 2005-11-23 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | L-丙氨酸衍生物 |
| WO2007141473A1 (en) * | 2006-06-09 | 2007-12-13 | Astrazeneca Ab | N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors |
| WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
| WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
| CN102127145B (zh) * | 2007-06-04 | 2012-07-04 | 北京大学 | 取代四氢异喹啉化合物、其制备方法及用途 |
| CN102225965B (zh) * | 2007-06-04 | 2013-03-27 | 北京大学 | 取代-四氢异喹啉-3-羧酸化合物、其制备方法及应用 |
| CN101318994B (zh) * | 2007-06-04 | 2012-03-28 | 北京大学 | 取代-四氢异喹啉-3-羧酸化合物、其制备方法及应用 |
| CN101318995B (zh) * | 2007-06-04 | 2011-04-20 | 北京大学 | 取代四氢异喹啉化合物、其制备方法及用途 |
| CN101497651B (zh) * | 2008-01-30 | 2012-06-27 | 首都医科大学 | 具有溶血栓活性的化合物、其制备方法、其应用 |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| DK3003284T3 (da) | 2013-06-06 | 2020-03-30 | Fibrogen Inc | Farmaceutiske formuleringer af en hif-hydroxylase-inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262069B1 (en) | 1997-08-29 | 2001-07-17 | Protherics Molecular Design Limited | 1-amino-7-isoquinoline derivatives as serine protease inhibitors |
| US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| DE60022508T2 (de) | 1999-06-14 | 2006-06-08 | Eli Lilly And Co., Indianapolis | Inhibitoren von serin proteasen |
| DE19932796A1 (de) * | 1999-07-14 | 2001-01-18 | Merck Patent Gmbh | Diacylhydrazinderivate |
-
2002
- 2002-03-06 DE DE10209692A patent/DE10209692A1/de not_active Withdrawn
-
2003
- 2003-02-07 KR KR10-2004-7013809A patent/KR20040089704A/ko not_active Application Discontinuation
- 2003-02-07 WO PCT/EP2003/001248 patent/WO2003074512A1/de not_active Application Discontinuation
- 2003-02-07 JP JP2003572980A patent/JP2005525363A/ja not_active Withdrawn
- 2003-02-07 RU RU2004129734/04A patent/RU2004129734A/ru not_active Application Discontinuation
- 2003-02-07 CA CA002478618A patent/CA2478618A1/en not_active Abandoned
- 2003-02-07 BR BR0308195-8A patent/BR0308195A/pt not_active IP Right Cessation
- 2003-02-07 PL PL03371216A patent/PL371216A1/xx unknown
- 2003-02-07 EP EP03714735A patent/EP1480971A1/de not_active Withdrawn
- 2003-02-07 AU AU2003218980A patent/AU2003218980A1/en not_active Abandoned
- 2003-02-07 CN CNA038051753A patent/CN1639150A/zh active Pending
- 2003-02-07 US US10/506,820 patent/US7060707B2/en not_active Expired - Fee Related
- 2003-02-07 MX MXPA04008469A patent/MXPA04008469A/es not_active Application Discontinuation
- 2003-03-05 AR ARP030100724A patent/AR038869A1/es not_active Application Discontinuation
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2004
- 2004-10-05 ZA ZA200408027A patent/ZA200408027B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1639150A (zh) | 2005-07-13 |
| DE10209692A1 (de) | 2003-09-18 |
| BR0308195A (pt) | 2005-01-04 |
| AU2003218980A1 (en) | 2003-09-16 |
| EP1480971A1 (de) | 2004-12-01 |
| WO2003074512A1 (de) | 2003-09-12 |
| US7060707B2 (en) | 2006-06-13 |
| US20050090525A1 (en) | 2005-04-28 |
| RU2004129734A (ru) | 2005-07-10 |
| CA2478618A1 (en) | 2003-09-12 |
| KR20040089704A (ko) | 2004-10-21 |
| AR038869A1 (es) | 2005-02-02 |
| JP2005525363A (ja) | 2005-08-25 |
| PL371216A1 (en) | 2005-06-13 |
| MXPA04008469A (es) | 2004-12-06 |
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