ZA200407465B - Combination of an aldosterone receptor antagonist and a bile acid sequestering agent - Google Patents
Combination of an aldosterone receptor antagonist and a bile acid sequestering agent Download PDFInfo
- Publication number
- ZA200407465B ZA200407465B ZA200407465A ZA200407465A ZA200407465B ZA 200407465 B ZA200407465 B ZA 200407465B ZA 200407465 A ZA200407465 A ZA 200407465A ZA 200407465 A ZA200407465 A ZA 200407465A ZA 200407465 B ZA200407465 B ZA 200407465B
- Authority
- ZA
- South Africa
- Prior art keywords
- bile acid
- sequestering agent
- acid sequestering
- composition
- group
- Prior art date
Links
- 239000003613 bile acid Substances 0.000 title claims description 92
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title claims description 88
- 239000003352 sequestering agent Substances 0.000 title claims description 82
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- GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 claims description 36
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- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 13
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims description 10
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims description 10
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- VTAKZNRDSPNOAU-UHFFFAOYSA-M 2-(chloromethyl)oxirane;hydron;prop-2-en-1-amine;n-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;dichloride Chemical compound Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C VTAKZNRDSPNOAU-UHFFFAOYSA-M 0.000 claims 28
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- DEMLYXMVPJAVFU-UHFFFAOYSA-N 2-(chloromethyl)oxirane;2-methyl-1h-imidazole Chemical compound ClCC1CO1.CC1=NC=CN1 DEMLYXMVPJAVFU-UHFFFAOYSA-N 0.000 claims 11
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Endocrinology (AREA)
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- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| US36539002P | 2002-03-18 | 2002-03-18 |
Publications (1)
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| ZA200407465B true ZA200407465B (en) | 2006-04-26 |
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| ZA200407465A ZA200407465B (en) | 2002-03-18 | 2004-09-16 | Combination of an aldosterone receptor antagonist and a bile acid sequestering agent |
Country Status (13)
| Country | Link |
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| US (1) | US20030219401A1 (xx) |
| EP (1) | EP1485105A1 (xx) |
| JP (1) | JP2005523910A (xx) |
| KR (1) | KR20040107481A (xx) |
| CN (1) | CN1642556A (xx) |
| AU (1) | AU2003222010A1 (xx) |
| BR (1) | BR0308517A (xx) |
| CA (1) | CA2479259A1 (xx) |
| IL (1) | IL163893A0 (xx) |
| MX (1) | MXPA04009039A (xx) |
| PL (1) | PL373029A1 (xx) |
| WO (1) | WO2003080069A1 (xx) |
| ZA (1) | ZA200407465B (xx) |
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| CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| US8652529B2 (en) * | 2005-11-10 | 2014-02-18 | Flamel Technologies | Anti-misuse microparticulate oral pharmaceutical form |
| WO2007094779A1 (en) * | 2006-02-14 | 2007-08-23 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture |
| WO2007145308A1 (ja) * | 2006-06-16 | 2007-12-21 | Mitsubishi Tanabe Pharma Corporation | 糸球体疾患の予防及び/または治療剤 |
| PT2124884T (pt) * | 2006-12-22 | 2019-09-17 | Ironwood Pharmaceuticals Inc | Composições compreendendo sequestradores de ácido biliar para tratar distúrbios esofágicos |
| US20110152204A1 (en) * | 2009-12-18 | 2011-06-23 | Satiogen Pharmaceuticals, Inc. | Treatment of Obesity or Diabetes with Bile Acid Sequestrants |
Family Cites Families (14)
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| US3013012A (en) * | 1960-12-22 | 1961-12-12 | Searle & Co | Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones |
| US3257390A (en) * | 1963-06-12 | 1966-06-21 | Merck & Co Inc | Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents |
| US3692895A (en) * | 1970-09-08 | 1972-09-19 | Norman A Nelson | Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria |
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4559332A (en) * | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| DE3506100A1 (de) * | 1985-02-18 | 1986-08-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3916112A1 (de) * | 1989-05-16 | 1990-11-22 | Schering Ag | Dihydrospirorenon als antiandrogen |
| US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5730992A (en) * | 1994-09-13 | 1998-03-24 | Ramot University Authority For Applied Research And Industrial Development, Ltd. | Compositions for the treatment of skin disorders |
| DE19627431A1 (de) * | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
| US6180597B1 (en) * | 1998-03-19 | 2001-01-30 | Brigham And Women's Hospital, Inc. | Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors |
| DK1100344T3 (da) * | 1998-07-30 | 2004-10-11 | Vital Living Inc | Chitosanholdige flydende præparater og fremgangsmåder til deres fremstilling og anvendelse |
| EP1140187B1 (en) * | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of an ibat inhibitor and a mtp inhibitor for cardiovascular indications |
| WO2002009683A2 (en) * | 2000-07-27 | 2002-02-07 | Pharmacia Corporation | Aldosterone blocker therapy to prevent or treat inflammation-related disorders |
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2003
- 2003-03-18 KR KR10-2004-7014563A patent/KR20040107481A/ko not_active Application Discontinuation
- 2003-03-18 AU AU2003222010A patent/AU2003222010A1/en not_active Abandoned
- 2003-03-18 PL PL03373029A patent/PL373029A1/xx not_active Application Discontinuation
- 2003-03-18 WO PCT/US2003/008207 patent/WO2003080069A1/en not_active Application Discontinuation
- 2003-03-18 CN CNA038063182A patent/CN1642556A/zh active Pending
- 2003-03-18 BR BR0308517-1A patent/BR0308517A/pt not_active IP Right Cessation
- 2003-03-18 JP JP2003577895A patent/JP2005523910A/ja not_active Withdrawn
- 2003-03-18 CA CA002479259A patent/CA2479259A1/en not_active Abandoned
- 2003-03-18 MX MXPA04009039A patent/MXPA04009039A/es not_active Application Discontinuation
- 2003-03-18 EP EP03717993A patent/EP1485105A1/en not_active Withdrawn
- 2003-03-18 US US10/391,343 patent/US20030219401A1/en not_active Abandoned
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2004
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- 2004-09-16 ZA ZA200407465A patent/ZA200407465B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040107481A (ko) | 2004-12-20 |
| EP1485105A1 (en) | 2004-12-15 |
| CA2479259A1 (en) | 2003-10-02 |
| MXPA04009039A (es) | 2005-01-25 |
| BR0308517A (pt) | 2005-02-01 |
| CN1642556A (zh) | 2005-07-20 |
| AU2003222010A1 (en) | 2003-10-08 |
| PL373029A1 (en) | 2005-08-08 |
| IL163893A0 (en) | 2005-12-18 |
| US20030219401A1 (en) | 2003-11-27 |
| JP2005523910A (ja) | 2005-08-11 |
| WO2003080069A1 (en) | 2003-10-02 |
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