ZA200406059B - Pharmaceutical composition for regeneration of cirrhotic liver. - Google Patents
Pharmaceutical composition for regeneration of cirrhotic liver. Download PDFInfo
- Publication number
- ZA200406059B ZA200406059B ZA200406059A ZA200406059A ZA200406059B ZA 200406059 B ZA200406059 B ZA 200406059B ZA 200406059 A ZA200406059 A ZA 200406059A ZA 200406059 A ZA200406059 A ZA 200406059A ZA 200406059 B ZA200406059 B ZA 200406059B
- Authority
- ZA
- South Africa
- Prior art keywords
- liver
- oltipraz
- rats
- cirrhotic
- cirrhosis
- Prior art date
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- 239000003826 tablet Substances 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020020007678A KR20030067935A (ko) | 2002-02-09 | 2002-02-09 | 올티프라즈를 포함하는 간경화(간경변증) 치료를 위한 간 조직 재생용 제약 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200406059B true ZA200406059B (en) | 2005-06-21 |
Family
ID=27725720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200406059A ZA200406059B (en) | 2002-02-09 | 2004-07-29 | Pharmaceutical composition for regeneration of cirrhotic liver. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20030171382A1 (zh) |
| EP (1) | EP1471914A4 (zh) |
| JP (1) | JP2005519926A (zh) |
| KR (1) | KR20030067935A (zh) |
| CN (1) | CN1278687C (zh) |
| AU (1) | AU2003206245B2 (zh) |
| BR (1) | BR0306923A (zh) |
| CA (1) | CA2473202C (zh) |
| MX (1) | MXPA04007675A (zh) |
| NO (1) | NO20042876L (zh) |
| PL (1) | PL371245A1 (zh) |
| RU (1) | RU2291696C2 (zh) |
| TW (1) | TWI248931B (zh) |
| WO (1) | WO2003066058A1 (zh) |
| ZA (1) | ZA200406059B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100629771B1 (ko) * | 2004-01-27 | 2006-09-28 | 씨제이 주식회사 | 결정성이 감소되거나 무정형화된 올티프라즈의 제조방법 |
| KR20060031956A (ko) * | 2004-10-11 | 2006-04-14 | 재단법인서울대학교산학협력재단 | ｐ90 리보솜 Ｓ6 키나제 1 (ＲＳＫ1)의 직접적인 키나제활성증진을 통한 간섬유화와 간경변증 예방 및 치료용약학조성물 |
| KR100604261B1 (ko) | 2004-10-11 | 2006-07-28 | 재단법인서울대학교산학협력재단 | 신규4,5,6,7-테트라히드로-[1,2]디티올로[4,3-ｃ]피리딘-3-티온계 화합물 |
| WO2007131973A2 (en) | 2006-05-11 | 2007-11-22 | Prendergast Patrick T | Compositions and methods for modulating the immune system |
| GB0704718D0 (en) * | 2007-03-12 | 2007-04-18 | Prendergast Patrick T | Compounds and methods for preventing and treating mucositis |
| KR101057485B1 (ko) * | 2008-08-04 | 2011-08-17 | 서울대학교산학협력단 | 1,2-디티올티온 유도체를 함유하는 엘엑스알-알파 과다발현으로 인한 질병의 예방 및 치료용 약학 조성물 |
| EP2346519B1 (en) | 2008-10-02 | 2015-12-02 | George Zabrecky | Methods and formulations for treating chronic liver disease |
| EP2674159B1 (de) | 2012-06-15 | 2016-04-27 | Phrontier S.A.R.L. | Pharmazeutische Zusammensetzung für die Leber-Regeneration |
| JP6876047B2 (ja) | 2015-09-08 | 2021-05-26 | オーピーツー ドラッグス | ミトコンドリアの活性酸素種（ｒｏｓ）産生に関連する疾患の治療のための化合物 |
| BR112018004518A2 (pt) | 2015-09-08 | 2019-03-19 | OP2 Drugs | compostos para o tratamento de doenças ligadas à produção de espécies reativas de oxigênio (ros) mitocondriais |
| CN108601840A (zh) * | 2015-12-07 | 2018-09-28 | 国立大学法人京都大学 | Pd-1信号抑制剂的并用疗法 |
| CN110662535A (zh) | 2017-03-07 | 2020-01-07 | Op2药品公司 | 用于治疗与线粒体活性氧(ros)产生相关的疾病的去甲基茴三硫衍生物 |
| KR102588061B1 (ko) * | 2019-08-29 | 2023-10-13 | 에스코-그래픽스 이미징 게엠베하 | 포토폴리머 노출에서의 사용을 위한 uv led 방사선 소스들 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794873A (fr) * | 1972-02-02 | 1973-08-01 | Rhone Poulenc Sa | Nouvelles sulfones a enchainement dimethyl-1,6 hexadien-1,5 ylene |
| DE2505869C3 (de) * | 1975-02-12 | 1978-05-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von symmetrischen Carotinoiden |
| JPS54160740A (en) * | 1978-06-09 | 1979-12-19 | Takeda Chem Ind Ltd | Anti-fibrotic agent |
| US4883887A (en) * | 1987-07-09 | 1989-11-28 | Hoffmann-La Roche Inc. | Sulfone polyene intermediates |
| US6517824B1 (en) * | 1990-05-14 | 2003-02-11 | University Of Medicine & Denistry Of New Jersey | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| US5686436A (en) * | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
| KR0138005B1 (ko) * | 1993-10-21 | 1998-05-15 | 김낙두 | 신규의 화학적 보호제(chemopreventive agent)및 그의 제조방법 |
| CA2113229C (en) * | 1994-01-11 | 1999-04-20 | Mark Pines | Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof |
| US5786344A (en) * | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
| EP0827742A1 (en) * | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
| US6294350B1 (en) * | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| US6046199A (en) * | 1998-01-14 | 2000-04-04 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives |
| KR100261139B1 (ko) * | 1998-01-16 | 2000-08-01 | 황준수 | 신규한 알릴티오피리다진 유도체 및 그의 제조방법 |
| AU6462500A (en) * | 1999-07-29 | 2001-02-19 | Patrick T. Prendergast | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement |
| US6242478B1 (en) * | 1999-12-10 | 2001-06-05 | Wake Forest University | Five member ring sulfenate esters and thiosulfinate esters |
| US7078045B2 (en) * | 2000-03-02 | 2006-07-18 | Sang-Geon Kim | Pharmaceutical composition for treatment and prevention of liver fibrosis and cirrhosis |
| KR100377789B1 (ko) * | 2000-03-02 | 2003-03-26 | 김상건 | 간섬유화 및 간경화 치료 및 예방용 의약 조성물 |
| RU2250768C2 (ru) * | 2000-03-02 | 2005-04-27 | Санг Геон КИМ | Фармацевтическая композиция и способ лечения прогрессирующего фиброза и цирроза печени |
| US20030191137A1 (en) * | 2000-04-07 | 2003-10-09 | Sang-Geon Kim | Prophylactic and therapeutic use of oltipraz as an antifibrotic and anticirrhotic agent in the liver and pharmaceutical composition containing oltipraz |
| KR100604261B1 (ko) * | 2004-10-11 | 2006-07-28 | 재단법인서울대학교산학협력재단 | 신규4,5,6,7-테트라히드로-[1,2]디티올로[4,3-ｃ]피리딘-3-티온계 화합물 |
-
2002
- 2002-02-09 KR KR1020020007678A patent/KR20030067935A/ko not_active IP Right Cessation
-
2003
- 2003-02-06 US US10/360,698 patent/US20030171382A1/en not_active Abandoned
- 2003-02-07 TW TW092102507A patent/TWI248931B/zh active
- 2003-02-08 CA CA002473202A patent/CA2473202C/en not_active Expired - Fee Related
- 2003-02-08 MX MXPA04007675A patent/MXPA04007675A/es active IP Right Grant
- 2003-02-08 WO PCT/KR2003/000278 patent/WO2003066058A1/en active Application Filing
- 2003-02-08 EP EP03703514A patent/EP1471914A4/en not_active Withdrawn
- 2003-02-08 AU AU2003206245A patent/AU2003206245B2/en not_active Ceased
- 2003-02-08 BR BR0306923-0A patent/BR0306923A/pt not_active IP Right Cessation
- 2003-02-08 CN CNB038029472A patent/CN1278687C/zh not_active Expired - Fee Related
- 2003-02-08 RU RU2004127128/15A patent/RU2291696C2/ru not_active IP Right Cessation
- 2003-02-08 JP JP2003565482A patent/JP2005519926A/ja active Pending
- 2003-02-08 PL PL03371245A patent/PL371245A1/xx not_active Application Discontinuation
-
2004
- 2004-07-07 NO NO20042876A patent/NO20042876L/no not_active Application Discontinuation
- 2004-07-29 ZA ZA200406059A patent/ZA200406059B/en unknown
-
2005
- 2005-10-28 US US11/261,884 patent/US20060063781A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005519926A (ja) | 2005-07-07 |
| US20060063781A1 (en) | 2006-03-23 |
| EP1471914A1 (en) | 2004-11-03 |
| KR20030067935A (ko) | 2003-08-19 |
| RU2004127128A (ru) | 2005-04-20 |
| US20030171382A1 (en) | 2003-09-11 |
| NO20042876L (no) | 2004-09-01 |
| WO2003066058A1 (en) | 2003-08-14 |
| RU2291696C2 (ru) | 2007-01-20 |
| EP1471914A4 (en) | 2007-08-08 |
| CA2473202A1 (en) | 2003-08-14 |
| BR0306923A (pt) | 2004-12-28 |
| AU2003206245A1 (en) | 2003-09-02 |
| CN1278687C (zh) | 2006-10-11 |
| CA2473202C (en) | 2007-11-13 |
| MXPA04007675A (es) | 2004-11-10 |
| TWI248931B (en) | 2006-02-11 |
| PL371245A1 (en) | 2005-06-13 |
| TW200305570A (en) | 2003-11-01 |
| AU2003206245B2 (en) | 2006-07-20 |
| CN1625399A (zh) | 2005-06-08 |
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