ZA200403093B - Medicament dispenser. - Google Patents
Medicament dispenser. Download PDFInfo
- Publication number
- ZA200403093B ZA200403093B ZA200403093A ZA200403093A ZA200403093B ZA 200403093 B ZA200403093 B ZA 200403093B ZA 200403093 A ZA200403093 A ZA 200403093A ZA 200403093 A ZA200403093 A ZA 200403093A ZA 200403093 B ZA200403093 B ZA 200403093B
- Authority
- ZA
- South Africa
- Prior art keywords
- fluorinated
- dispenser
- valve
- coating
- medicament
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims description 51
- 238000000576 coating method Methods 0.000 claims description 57
- 238000000034 method Methods 0.000 claims description 57
- 239000011248 coating agent Substances 0.000 claims description 54
- 230000008569 process Effects 0.000 claims description 44
- 239000000178 monomer Substances 0.000 claims description 38
- 239000007789 gas Substances 0.000 claims description 22
- 239000003380 propellant Substances 0.000 claims description 21
- 229940079593 drug Drugs 0.000 claims description 17
- 239000012530 fluid Substances 0.000 claims description 14
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 12
- 238000002203 pretreatment Methods 0.000 claims description 9
- 229910052786 argon Inorganic materials 0.000 claims description 6
- 230000008021 deposition Effects 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 5
- 239000011737 fluorine Substances 0.000 claims description 5
- 208000023504 respiratory system disease Diseases 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 238000011109 contamination Methods 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 238000011010 flushing procedure Methods 0.000 claims description 2
- 150000005828 hydrofluoroalkanes Chemical class 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 238000009832 plasma treatment Methods 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 230000001839 systemic circulation Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 description 12
- 238000009472 formulation Methods 0.000 description 11
- 239000000443 aerosol Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 229920001707 polybutylene terephthalate Polymers 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- -1 Polytetrafluoroethylene Polymers 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 229940071648 metered dose inhaler Drugs 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000004411 aluminium Substances 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000008249 pharmaceutical aerosol Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 3
- 239000013583 drug formulation Substances 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 229920002313 fluoropolymer Polymers 0.000 description 3
- 229910052755 nonmetal Inorganic materials 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 101100114968 Mus musculus Csf3 gene Proteins 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- WOZVHXUHUFLZGK-UHFFFAOYSA-N dimethyl terephthalate Chemical compound COC(=O)C1=CC=C(C(=O)OC)C=C1 WOZVHXUHUFLZGK-UHFFFAOYSA-N 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000005028 tinplate Substances 0.000 description 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910000881 Cu alloy Inorganic materials 0.000 description 1
- 229920002943 EPDM rubber Polymers 0.000 description 1
- 208000026344 Nasal disease Diseases 0.000 description 1
- 229920000459 Nitrile rubber Polymers 0.000 description 1
- 208000030880 Nose disease Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000000426 electronic spectroscopy Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000012632 extractable Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002843 nonmetals Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/62—Plasma-deposition of organic layers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/14—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by electrical means
- B05D3/141—Plasma treatment
- B05D3/142—Pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D5/00—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
- B05D5/08—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface
- B05D5/083—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface involving the use of fluoropolymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/22—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to internal surfaces, e.g. of tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Confectionery (AREA)
- Valve Device For Special Equipments (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0125380.6A GB0125380D0 (en) | 2001-10-23 | 2001-10-23 | Medicament dispenser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403093B true ZA200403093B (en) | 2005-04-22 |
Family
ID=9924336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200403093A ZA200403093B (en) | 2001-10-23 | 2004-04-22 | Medicament dispenser. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20050201945A1 (de) |
| EP (1) | EP1439877B1 (de) |
| JP (1) | JP2005506155A (de) |
| CN (1) | CN1578686A (de) |
| AT (1) | ATE329643T1 (de) |
| BR (1) | BR0213241A (de) |
| CA (1) | CA2463780A1 (de) |
| DE (1) | DE60212432T2 (de) |
| GB (1) | GB0125380D0 (de) |
| MX (1) | MXPA04003876A (de) |
| WO (1) | WO2003035154A1 (de) |
| ZA (1) | ZA200403093B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805938D0 (en) * | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| EP1595913A1 (de) * | 2004-05-14 | 2005-11-16 | Inergy Automotive Systems Research (SA) | Verfahren zur Herstellung eines hohlen Kraftstoffsystemelements |
| FR2880027B1 (fr) * | 2004-12-23 | 2007-04-20 | Innovative Systems & Technolog | Procede de traitement d'un materiau polymere, dispositif pour la mise en oeuvre de ce procede et utilisation de ce dispositif au traitement de corps creux |
| DE102006024675A1 (de) * | 2006-05-26 | 2007-11-29 | Robert Bosch Gmbh | Verfahren und Vorrichtung zur Oberflächenbehandlung an Behältnissen oder Gegenständen |
| GB0710490D0 (en) * | 2007-06-01 | 2007-07-11 | Innovatek Medical Ltd | Medicament dispenser device |
| GB0710475D0 (en) * | 2007-06-01 | 2007-07-11 | Innovatek Medical Ltd | Elastomeric sales |
| GB0710488D0 (en) * | 2007-06-01 | 2007-07-11 | Innovatek Medical Ltd | Methods of treating components of a medical dispenser device |
| EP2427902B1 (de) | 2009-05-06 | 2017-01-18 | 3M Innovative Properties Company | Vorrichtung und verfahren zur plasmabehandlung von behältern |
| FR2954329B1 (fr) * | 2009-12-23 | 2013-01-18 | Valois Sas | Procede de traitement de surface elastomere d'un dispositif de distribution de produit fluide. |
| BR112012019878A2 (pt) * | 2010-02-10 | 2017-10-10 | Astrazeneca Uk Ltd | processo para fornecimento de um receptáculo cheio para um inalador |
| GB201003273D0 (en) * | 2010-02-26 | 2010-04-14 | Portal Medical Ltd | Medicament dispenser device |
| GB201003275D0 (en) * | 2010-02-26 | 2010-04-14 | Portal Medical Ltd | Method of manufacturing a medicament dispenser device |
| GB2476004B (en) * | 2011-02-23 | 2011-12-28 | Portal Medical Ltd | Medicament Dispenser Device |
| FR2979214B1 (fr) * | 2011-08-26 | 2014-04-25 | Seb Sa | Article comportant un revetement antiadhesif presentant des proprietes ameliorees d'adherence au support |
| FR3003482B1 (fr) * | 2013-03-19 | 2016-06-24 | Aptar France Sas | Procede de traitement de surface d'une valve doseuse. |
| CA3038721A1 (en) * | 2016-09-30 | 2018-04-05 | Mayo Foundation For Medical Education And Research | Viral vectors for nuclear reprogramming |
| GB201717996D0 (en) * | 2017-10-31 | 2017-12-13 | Portal Medical Ltd | Medicament dispenser device |
| GB202001537D0 (en) * | 2020-02-05 | 2020-03-18 | Consort Medical Plc | Pressurised dispensing container |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649071A (en) * | 1984-04-28 | 1987-03-10 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Composite material and process for producing the same |
| DE3482168D1 (de) * | 1984-09-28 | 1990-06-13 | Japan Synthetic Rubber Co Ltd | Duenner kunststoffilm und ein solchen film enthaltender gegenstand. |
| US4718907A (en) * | 1985-06-20 | 1988-01-12 | Atrium Medical Corporation | Vascular prosthesis having fluorinated coating with varying F/C ratio |
| US5091204A (en) * | 1985-08-23 | 1992-02-25 | Weshington Research Foundation | Polymeric intraocular lens material having improved surface properties |
| US5345980A (en) * | 1989-09-21 | 1994-09-13 | Glaxo Group Limited | Method and apparatus an aerosol container |
| US5261538A (en) * | 1992-04-21 | 1993-11-16 | Glaxo Inc. | Aerosol testing method |
| JP2803017B2 (ja) * | 1993-06-07 | 1998-09-24 | 工業技術院長 | 抗血栓性医用材料及び医療用具並びにこれらの製造方法、製造装置及びプラズマ処理装置 |
| US6596260B1 (en) * | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
| US5449104A (en) * | 1994-03-23 | 1995-09-12 | Armament Systems & Procedures | Baton carrier for expandable batons |
| JPH11501892A (ja) * | 1995-03-10 | 1999-02-16 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | エアロゾルバルブ |
| EP0820323B1 (de) * | 1995-04-14 | 2003-09-24 | SmithKline Beecham Corporation | Dosierinhalator für salmeterol |
| US6132813A (en) * | 1997-12-11 | 2000-10-17 | International Business Machines Corporation | High density plasma surface modification for improving antiwetting properties |
| GB9805938D0 (en) * | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| GB2355252B (en) * | 1999-10-14 | 2002-01-23 | Bespak Plc | Improvements in drug delivery devices |
-
2001
- 2001-10-23 GB GBGB0125380.6A patent/GB0125380D0/en not_active Ceased
-
2002
- 2002-10-23 BR BR0213241-9A patent/BR0213241A/pt not_active IP Right Cessation
- 2002-10-23 AT AT02777443T patent/ATE329643T1/de not_active IP Right Cessation
- 2002-10-23 US US10/493,327 patent/US20050201945A1/en not_active Abandoned
- 2002-10-23 CN CN02821004.2A patent/CN1578686A/zh active Pending
- 2002-10-23 WO PCT/GB2002/004794 patent/WO2003035154A1/en active IP Right Grant
- 2002-10-23 JP JP2003537716A patent/JP2005506155A/ja active Pending
- 2002-10-23 DE DE60212432T patent/DE60212432T2/de not_active Expired - Lifetime
- 2002-10-23 MX MXPA04003876A patent/MXPA04003876A/es not_active Application Discontinuation
- 2002-10-23 EP EP02777443A patent/EP1439877B1/de not_active Expired - Lifetime
- 2002-10-23 CA CA002463780A patent/CA2463780A1/en not_active Abandoned
-
2004
- 2004-04-22 ZA ZA200403093A patent/ZA200403093B/en unknown
-
2009
- 2009-09-08 US US12/555,516 patent/US20100003420A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1439877A1 (de) | 2004-07-28 |
| JP2005506155A (ja) | 2005-03-03 |
| WO2003035154A1 (en) | 2003-05-01 |
| CN1578686A (zh) | 2005-02-09 |
| US20100003420A1 (en) | 2010-01-07 |
| US20050201945A1 (en) | 2005-09-15 |
| DE60212432T2 (de) | 2007-04-19 |
| BR0213241A (pt) | 2004-09-28 |
| EP1439877B1 (de) | 2006-06-14 |
| DE60212432D1 (de) | 2006-07-27 |
| GB0125380D0 (en) | 2001-12-12 |
| CA2463780A1 (en) | 2003-05-01 |
| ATE329643T1 (de) | 2006-07-15 |
| MXPA04003876A (es) | 2004-07-08 |
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