ZA200402229B - Reduced toxicity cisplatin formulations and methods for using the same. - Google Patents
Reduced toxicity cisplatin formulations and methods for using the same. Download PDFInfo
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- ZA200402229B ZA200402229B ZA200402229A ZA200402229A ZA200402229B ZA 200402229 B ZA200402229 B ZA 200402229B ZA 200402229 A ZA200402229 A ZA 200402229A ZA 200402229 A ZA200402229 A ZA 200402229A ZA 200402229 B ZA200402229 B ZA 200402229B
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- cisplatin
- active agent
- reducing agent
- toxicity reducing
- toxicity
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Classifications
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32456601P | 2001-09-24 | 2001-09-24 |
Publications (1)
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|---|---|
| ZA200402229B true ZA200402229B (en) | 2005-03-22 |
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| ZA200402229A ZA200402229B (en) | 2001-09-24 | 2004-03-19 | Reduced toxicity cisplatin formulations and methods for using the same. |
Country Status (18)
| Country | Link |
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| US (1) | US20040258771A1 (fr) |
| EP (1) | EP1435963A4 (fr) |
| JP (1) | JP2005510471A (fr) |
| KR (1) | KR20040048900A (fr) |
| CN (2) | CN1589149A (fr) |
| AU (1) | AU2002334595B2 (fr) |
| BR (1) | BR0212744A (fr) |
| CA (1) | CA2461219A1 (fr) |
| EA (1) | EA007481B1 (fr) |
| HU (1) | HUP0500642A2 (fr) |
| IL (1) | IL160960A0 (fr) |
| MX (1) | MXPA04002707A (fr) |
| NO (1) | NO20041484L (fr) |
| NZ (1) | NZ531936A (fr) |
| PL (1) | PL370867A1 (fr) |
| SK (1) | SK1472004A3 (fr) |
| WO (1) | WO2003026570A2 (fr) |
| ZA (1) | ZA200402229B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8815833B2 (en) | 2006-11-09 | 2014-08-26 | Seidose, LLC | Stable amifostine liquid concentrate |
| UY30915A1 (es) * | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
| US20100035853A1 (en) * | 2008-08-07 | 2010-02-11 | Hyogo College Of Medicine | Method for preventing or treating cisplatin-induced nephrotoxicity |
| WO2011097480A1 (fr) * | 2010-02-05 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | Compositions exosomales et procédés pour le traitement de maladies |
| CN103044338B (zh) * | 2012-12-12 | 2016-08-03 | 天津医科大学总医院 | miR-21小分子抑制剂及应用 |
| US11554138B2 (en) | 2015-07-16 | 2023-01-17 | The University Of Hong Kong | Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy |
| EP3538074B1 (fr) * | 2016-11-11 | 2023-07-26 | Western University Of Health Sciences | Méthodes de traitement de carcinomes urothéliaux de la voie excrétrice supérieure |
| CN112574255B (zh) * | 2019-09-27 | 2024-05-10 | 中国科学院上海有机化学研究所 | 一类基于有机胂的cdk抑制剂及其制备方法和用途 |
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|---|---|---|---|---|
| US4310515A (en) * | 1978-05-30 | 1982-01-12 | Bristol-Myers Company | Pharmaceutical compositions of cisplatin |
| US4302446A (en) * | 1979-10-02 | 1981-11-24 | Bristol-Myers Company | Pharmaceutical compositions |
| US5059591B1 (en) * | 1983-05-26 | 2000-04-25 | Liposome Co Inc | Drug preparations of reduced toxicity |
| GB8806224D0 (en) * | 1988-03-16 | 1988-04-13 | Johnson Matthey Plc | Platinum chemotherapeutic product |
| US5814307A (en) * | 1989-04-10 | 1998-09-29 | Bristol-Myers Squibb Company | Method for regulating cell growth, leukocyte differentiation and tumor cell growth using Oncostatin M to stimulate synthesis of IL-6 |
| US5770576A (en) * | 1989-08-30 | 1998-06-23 | Cytran, Inc. | Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity |
| DE4024885C2 (de) * | 1990-08-06 | 2002-07-18 | Nattermann A & Cie | Verwendung von 2-Phenyl-1,2-benzisoselenazol-3(2H)-on |
| US5366723A (en) * | 1993-03-05 | 1994-11-22 | Istvan Tulok | Method of alleviating toxicity originating from treatment with anticancer platinum compounds |
| JPH06321792A (ja) * | 1993-05-18 | 1994-11-22 | Tsumura & Co | 副作用軽減剤 |
| US5646011A (en) * | 1994-04-08 | 1997-07-08 | Yokoyama; Shiro | Cisplatin resistance gene and uses therefor |
| US5789000A (en) * | 1994-11-14 | 1998-08-04 | Bionumerik Pharmaceuticals, Inc. | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum |
| US5792748A (en) * | 1995-06-07 | 1998-08-11 | The General Hospital Corporation | Method for inhibiting neoplastic disease in mammals |
| US5922689A (en) * | 1995-09-11 | 1999-07-13 | Unitech Pharmaceuticals, Inc. | Cisplatin analogs for cancer treatment |
| US6077545A (en) * | 1995-10-30 | 2000-06-20 | Matrix Pharmaceuticals, Inc. | Process and composition for therapeutic cisplatin (CDDP) |
| ES2208946T3 (es) * | 1996-08-23 | 2004-06-16 | Sequus Pharmaceuticals, Inc. | Liposomas que contienen un compuesto de cisplatino. |
| CA2265983C (fr) * | 1996-10-03 | 2003-12-23 | Kathleen C. M. Campbell | Utilisation therapeutique de methionine d pour reduire la toxicite de composes antitumoraux contenant du platine |
| US6187817B1 (en) * | 1996-10-03 | 2001-02-13 | Southern Illinois University School Of Medicine | Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds |
| US6251355B1 (en) * | 1996-12-25 | 2001-06-26 | Nippon Kayaku Kabushiki Kaisha | Fine cisplatin powder and process for the production thereof |
| US6030783A (en) * | 1997-01-31 | 2000-02-29 | Massachusetts Institute Of Technology | Photo-potentiation of cisplatin chemotherapy |
| US5994409A (en) * | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6001817A (en) * | 1998-01-12 | 1999-12-14 | Unitech Pharmaceuticals, Inc. | Pharmaceutical composition comprised of cisplatin, and processes for making and using same |
| US6074626A (en) * | 1998-03-20 | 2000-06-13 | Molecular Radiation Management, Inc. | Radioactive cisplatin in the treatment of cancer |
| WO2000023074A1 (fr) * | 1998-10-22 | 2000-04-27 | Binex Co., Ltd. | Composition pharmaceutique contenant de la decursine |
| US6130245A (en) * | 1998-10-26 | 2000-10-10 | Unitech Pharmaceuticals, Inc. | Dinuclear platinum complexes as cisplatin analogs for cancer treatment |
| JP5409981B2 (ja) * | 2000-05-15 | 2014-02-05 | セルジーン コーポレイション | 癌治療用の組成物および方法 |
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- 2002-09-20 CA CA002461219A patent/CA2461219A1/fr not_active Abandoned
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- 2002-09-20 AU AU2002334595A patent/AU2002334595B2/en not_active Ceased
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- 2002-09-20 BR BR0212744-0A patent/BR0212744A/pt not_active Withdrawn
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- 2002-09-20 EP EP02799593A patent/EP1435963A4/fr not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101062053A (zh) | 2007-10-31 |
| MXPA04002707A (es) | 2005-06-06 |
| WO2003026570A3 (fr) | 2004-01-22 |
| EP1435963A2 (fr) | 2004-07-14 |
| WO2003026570A2 (fr) | 2003-04-03 |
| NO20041484L (no) | 2004-04-13 |
| AU2002334595B2 (en) | 2007-03-01 |
| SK1472004A3 (en) | 2004-10-05 |
| PL370867A1 (en) | 2005-05-30 |
| JP2005510471A (ja) | 2005-04-21 |
| US20040258771A1 (en) | 2004-12-23 |
| EA200400348A1 (ru) | 2005-04-28 |
| CA2461219A1 (fr) | 2003-04-03 |
| BR0212744A (pt) | 2005-10-25 |
| EP1435963A4 (fr) | 2005-10-26 |
| NZ531936A (en) | 2006-10-27 |
| HUP0500642A2 (hu) | 2005-11-28 |
| KR20040048900A (ko) | 2004-06-10 |
| EA007481B1 (ru) | 2006-10-27 |
| IL160960A0 (en) | 2004-08-31 |
| CN1589149A (zh) | 2005-03-02 |
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