ZA200400918B - Tricyclic imidazopyridines. - Google Patents
Tricyclic imidazopyridines. Download PDFInfo
- Publication number
- ZA200400918B ZA200400918B ZA200400918A ZA200400918A ZA200400918B ZA 200400918 B ZA200400918 B ZA 200400918B ZA 200400918 A ZA200400918 A ZA 200400918A ZA 200400918 A ZA200400918 A ZA 200400918A ZA 200400918 B ZA200400918 B ZA 200400918B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- hydroxy
- radical
- Prior art date
Links
- 150000005232 imidazopyridines Chemical class 0.000 title description 3
- -1 cyanomethyl Chemical group 0.000 claims description 148
- 150000001875 compounds Chemical class 0.000 claims description 88
- 239000001257 hydrogen Substances 0.000 claims description 43
- 229910052739 hydrogen Inorganic materials 0.000 claims description 43
- 150000002431 hydrogen Chemical group 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 30
- 229910052736 halogen Inorganic materials 0.000 claims description 21
- 150000002367 halogens Chemical class 0.000 claims description 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
- 239000001301 oxygen Substances 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 9
- CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical compound C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000001424 substituent group Chemical group 0.000 claims description 7
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 125000001544 thienyl group Chemical group 0.000 claims description 5
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 4
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- 125000003118 aryl group Chemical group 0.000 claims description 3
- 239000000460 chlorine Chemical group 0.000 claims description 3
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- 125000002541 furyl group Chemical group 0.000 claims description 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 3
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
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- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
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- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 2
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- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
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- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000004957 nitroimidazoles Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 1
- 229960002369 oxyphencyclimine Drugs 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 229960005019 pantoprazole Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- RMHMFHUVIITRHF-UHFFFAOYSA-N pirenzepine Chemical compound C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 description 1
- 229960004633 pirenzepine Drugs 0.000 description 1
- 150000007519 polyprotic acids Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- BZGIPVGCJGXQTA-UHFFFAOYSA-N s-[2-(diethylamino)ethyl] n,n-diphenylcarbamothioate Chemical compound C=1C=CC=CC=1N(C(=O)SCCN(CC)CC)C1=CC=CC=C1 BZGIPVGCJGXQTA-UHFFFAOYSA-N 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229950004351 telenzepine Drugs 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01119321 | 2001-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200400918B true ZA200400918B (en) | 2005-04-20 |
Family
ID=8178292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200400918A ZA200400918B (en) | 2001-08-10 | 2004-02-04 | Tricyclic imidazopyridines. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7223771B2 (fr) |
| EP (1) | EP1419163B9 (fr) |
| JP (1) | JP2005504761A (fr) |
| KR (1) | KR20040023739A (fr) |
| CN (1) | CN1329395C (fr) |
| AT (1) | ATE297931T1 (fr) |
| BR (1) | BR0211826A (fr) |
| CA (1) | CA2452803A1 (fr) |
| DE (1) | DE60204701T2 (fr) |
| DK (1) | DK1419163T5 (fr) |
| EA (1) | EA007683B1 (fr) |
| ES (1) | ES2243788T3 (fr) |
| HK (1) | HK1066213A1 (fr) |
| HR (1) | HRP20040229A2 (fr) |
| HU (1) | HUP0500330A3 (fr) |
| IL (1) | IL159554A0 (fr) |
| MX (1) | MXPA04001277A (fr) |
| NO (1) | NO20040604L (fr) |
| NZ (1) | NZ531520A (fr) |
| PL (1) | PL368195A1 (fr) |
| PT (1) | PT1419163E (fr) |
| SI (1) | SI1419163T1 (fr) |
| WO (1) | WO2003014123A1 (fr) |
| ZA (1) | ZA200400918B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006522071A (ja) * | 2003-04-04 | 2006-09-28 | アルタナ ファルマ アクチエンゲゼルシャフト | 環式ベンゾイミダゾール |
| AR044129A1 (es) | 2003-05-06 | 2005-08-24 | Altana Pharma Ag | Compuestos intermedios de imidazopiridina. proceso de preparacion. |
| MXPA05012463A (es) * | 2003-05-27 | 2006-01-30 | Altana Pharma Ag | Combinaciones farmaceuticas de un inhibidor de bomba protonica y un compuesto que modifica la motilidad gastrointestinal. |
| US7326784B2 (en) | 2003-12-19 | 2008-02-05 | Altana Pharma Ag | Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives |
| AR046941A1 (es) * | 2003-12-19 | 2006-01-04 | Altana Pharma Ag | Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico |
| AR047605A1 (es) * | 2004-02-17 | 2006-01-25 | Altana Pharma Ag | Imidazopiridinas triciclicas e intermediarios en la sintesis de las mismas,sus procesos de preparacion,composiciones farmaceuticas que los contienen y usos. |
| EP1735318A2 (fr) * | 2004-03-17 | 2006-12-27 | Altana Pharma AG | Dérivés de la 7h-8,9-dihydro-pyrano(2,3-c)imidazo(1,2a)pyridine et leur utilisation comme inhibiteurs de la sécrétion d'acide gastrique |
| EP1805173A2 (fr) * | 2004-03-22 | 2007-07-11 | Altana Pharma AG | Dérivés de 7, 8, 9, 10-tetrahydroimidazo [2,1-a] isochinolines et leur utilisation en tant qu' inhibiteurs de sécrétion de l' acide gastrique |
| AR048869A1 (es) * | 2004-04-26 | 2006-06-07 | Altana Pharma Ag | Bencimidazoles triciclicos |
| ATE374774T1 (de) * | 2004-06-09 | 2007-10-15 | Nycomed Gmbh | Substituierte tricyclische benzimidazole |
| AR051041A1 (es) * | 2004-10-04 | 2006-12-13 | Altana Pharma Ag | Bencimidazoles triciclicos condensados |
| AR054772A1 (es) * | 2005-06-16 | 2007-07-18 | Altana Pharma Ag | Espiro- imidazopiridinas como inhibidores de la secrecion de acido gastrico |
| EP2004643A1 (fr) * | 2006-03-31 | 2008-12-24 | Novartis AG | Composés organiques |
| WO2008071766A2 (fr) * | 2006-12-14 | 2008-06-19 | Nycomed Gmbh | Dérivés d'imidazopyridine substitués par spiro, pharmaceutiquement actifs |
| KR200452179Y1 (ko) * | 2009-05-20 | 2011-02-10 | 주식회사 신성일렉스 | 항공 장애물 표시 장치 |
| KR101605063B1 (ko) | 2009-07-09 | 2016-03-21 | 라퀄리아 파마 인코포레이티드 | 소화관 운동이상이 관여하는 질환의 치료용 산 펌프 길항제 |
| GB201321730D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4468400A (en) * | 1982-12-20 | 1984-08-28 | Schering Corporation | Antiulcer tricyclic imidazo [1,2-a]pyridines |
| SE9401197D0 (sv) * | 1994-04-11 | 1994-04-11 | Astra Ab | Active compounds |
| DE69823493T2 (de) * | 1997-03-24 | 2009-09-24 | Nycomed Gmbh | Tetrahydropyridoverbindungen |
| EP0984969B1 (fr) * | 1997-05-28 | 2008-07-09 | Nycomed GmbH | Dihydropyrannes fondus |
| HUP0001555A3 (en) * | 1997-10-30 | 2001-01-29 | Altana Pharma Ag | Tetrahydro-imidazo-naphthyridine derivatives, pharmaceutical compositions thereof and process for their preparation |
| MXPA02009549A (es) * | 2000-03-29 | 2004-05-14 | Altana Pharma Ag | Imidazopiridinas triciclicas. |
-
2002
- 2002-07-31 MX MXPA04001277A patent/MXPA04001277A/es active IP Right Grant
- 2002-07-31 PL PL02368195A patent/PL368195A1/xx not_active Application Discontinuation
- 2002-07-31 PT PT02794528T patent/PT1419163E/pt unknown
- 2002-07-31 EP EP02794528A patent/EP1419163B9/fr not_active Expired - Lifetime
- 2002-07-31 IL IL15955402A patent/IL159554A0/xx unknown
- 2002-07-31 SI SI200230179T patent/SI1419163T1/sl unknown
- 2002-07-31 HU HU0500330A patent/HUP0500330A3/hu unknown
- 2002-07-31 NZ NZ531520A patent/NZ531520A/en unknown
- 2002-07-31 EA EA200400254A patent/EA007683B1/ru not_active IP Right Cessation
- 2002-07-31 JP JP2003519072A patent/JP2005504761A/ja not_active Withdrawn
- 2002-07-31 DE DE60204701T patent/DE60204701T2/de not_active Expired - Fee Related
- 2002-07-31 DK DK02794528T patent/DK1419163T5/da active
- 2002-07-31 US US10/485,515 patent/US7223771B2/en not_active Expired - Fee Related
- 2002-07-31 WO PCT/EP2002/008505 patent/WO2003014123A1/fr active IP Right Grant
- 2002-07-31 AT AT02794528T patent/ATE297931T1/de not_active IP Right Cessation
- 2002-07-31 CA CA002452803A patent/CA2452803A1/fr not_active Abandoned
- 2002-07-31 CN CNB028156013A patent/CN1329395C/zh not_active Expired - Fee Related
- 2002-07-31 BR BR0211826-2A patent/BR0211826A/pt not_active IP Right Cessation
- 2002-07-31 KR KR10-2004-7001988A patent/KR20040023739A/ko not_active Application Discontinuation
- 2002-07-31 ES ES02794528T patent/ES2243788T3/es not_active Expired - Lifetime
-
2004
- 2004-02-04 ZA ZA200400918A patent/ZA200400918B/en unknown
- 2004-02-10 NO NO20040604A patent/NO20040604L/no not_active Application Discontinuation
- 2004-03-08 HR HR20040229A patent/HRP20040229A2/hr not_active Application Discontinuation
- 2004-11-16 HK HK04109042A patent/HK1066213A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60204701T2 (de) | 2006-08-03 |
| EP1419163A1 (fr) | 2004-05-19 |
| SI1419163T1 (sl) | 2005-12-31 |
| WO2003014123A1 (fr) | 2003-02-20 |
| CN1541219A (zh) | 2004-10-27 |
| ATE297931T1 (de) | 2005-07-15 |
| EA200400254A1 (ru) | 2004-08-26 |
| ES2243788T3 (es) | 2005-12-01 |
| CN1329395C (zh) | 2007-08-01 |
| EP1419163B9 (fr) | 2005-11-09 |
| EP1419163B1 (fr) | 2005-06-15 |
| US20050049272A1 (en) | 2005-03-03 |
| NZ531520A (en) | 2005-10-28 |
| PL368195A1 (en) | 2005-03-21 |
| IL159554A0 (en) | 2004-06-01 |
| HK1066213A1 (en) | 2005-03-18 |
| BR0211826A (pt) | 2005-06-28 |
| JP2005504761A (ja) | 2005-02-17 |
| CA2452803A1 (fr) | 2003-02-20 |
| HUP0500330A3 (en) | 2009-12-28 |
| HUP0500330A2 (hu) | 2005-07-28 |
| DK1419163T5 (da) | 2005-12-19 |
| NO20040604L (no) | 2004-02-10 |
| MXPA04001277A (es) | 2004-05-27 |
| EA007683B1 (ru) | 2006-12-29 |
| HRP20040229A2 (en) | 2005-02-28 |
| DK1419163T3 (da) | 2005-10-17 |
| PT1419163E (pt) | 2005-10-31 |
| KR20040023739A (ko) | 2004-03-18 |
| US7223771B2 (en) | 2007-05-29 |
| DE60204701D1 (de) | 2005-07-21 |
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