ZA200307677B - Modified interferon alpha with reduced immunogenicity. - Google Patents

Modified interferon alpha with reduced immunogenicity. Download PDF

Info

Publication number
ZA200307677B
ZA200307677B ZA200307677A ZA200307677A ZA200307677B ZA 200307677 B ZA200307677 B ZA 200307677B ZA 200307677 A ZA200307677 A ZA 200307677A ZA 200307677 A ZA200307677 A ZA 200307677A ZA 200307677 B ZA200307677 B ZA 200307677B
Authority
ZA
South Africa
Prior art keywords
molecule
amino acid
modified
peptide
sequence
Prior art date
Application number
ZA200307677A
Other languages
English (en)
Inventor
Francis J Carr
Tim Jones
John Watkins
Graham Carter
Matthew Baker
Marian Hanalon
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200307677B publication Critical patent/ZA200307677B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200307677A 2001-03-02 2003-10-01 Modified interferon alpha with reduced immunogenicity. ZA200307677B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01105088 2001-03-02

Publications (1)

Publication Number Publication Date
ZA200307677B true ZA200307677B (en) 2004-07-13

Family

ID=8176646

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307677A ZA200307677B (en) 2001-03-02 2003-10-01 Modified interferon alpha with reduced immunogenicity.

Country Status (13)

Country Link
US (1) US20060062761A1 (de)
EP (1) EP1379555A2 (de)
JP (1) JP2004535173A (de)
KR (1) KR20030081479A (de)
CN (1) CN1529714A (de)
BR (1) BR0207704A (de)
CA (1) CA2439690A1 (de)
HU (1) HUP0303309A2 (de)
MX (1) MXPA03007838A (de)
PL (1) PL363181A1 (de)
RU (1) RU2003129056A (de)
WO (1) WO2002085941A2 (de)
ZA (1) ZA200307677B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2500626A1 (en) * 2002-10-01 2004-04-15 Xencor, Inc. Interferon variants with improved properties
WO2004074486A2 (en) * 2003-02-18 2004-09-02 Merck Patent Gmbh Fusion proteins of interferon alpha muteins with improved properties
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
EP2167528B1 (de) * 2007-06-21 2018-01-10 Angelica Therapeutics, INC. Modifizierte toxine
WO2009110944A1 (en) * 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
WO2010030671A1 (en) * 2008-09-09 2010-03-18 University Of Medicine And Dentistry Of New Jersey Type i interferon antagonists
EP2968450A4 (de) 2013-03-15 2016-10-26 Angelica Therapeutics Inc Modifizierte toxine
CN105200017A (zh) * 2015-10-16 2015-12-30 西安医学院 一种去除a47l降低痘苗病毒免疫优势的方法及病毒
CN105255840A (zh) * 2015-10-16 2016-01-20 西安医学院 通过去除显性表位b8r重组痘苗病毒的方法及其病毒
WO2018200635A1 (en) 2017-04-28 2018-11-01 The Regents Of The University Of Colorado, A Body Corporate Methods of treating rheumatoid arthritis using rna-guided genome editing of hla gene
AR117715A1 (es) * 2019-12-17 2021-08-25 Univ Nacional Del Litoral Unl Interferón hiperglicosilado con inmunogenicidad reducida
JP2024517476A (ja) * 2021-05-10 2024-04-22 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト 自己免疫を治療するためのhla対立遺伝子のポケット操作

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2248538A1 (en) * 1996-03-14 1997-09-18 The Immune Response Corporation Targeted delivery of genes encoding interferon

Also Published As

Publication number Publication date
BR0207704A (pt) 2004-07-06
RU2003129056A (ru) 2005-04-20
WO2002085941A2 (en) 2002-10-31
HUP0303309A2 (hu) 2003-12-29
EP1379555A2 (de) 2004-01-14
MXPA03007838A (es) 2003-12-08
PL363181A1 (en) 2004-11-15
WO2002085941A3 (en) 2003-10-30
US20060062761A1 (en) 2006-03-23
CA2439690A1 (en) 2002-10-31
KR20030081479A (ko) 2003-10-17
JP2004535173A (ja) 2004-11-25
CN1529714A (zh) 2004-09-15

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