ZA200306615B - Pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing them. - Google Patents
Pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing them. Download PDFInfo
- Publication number
- ZA200306615B ZA200306615B ZA200306615A ZA200306615A ZA200306615B ZA 200306615 B ZA200306615 B ZA 200306615B ZA 200306615 A ZA200306615 A ZA 200306615A ZA 200306615 A ZA200306615 A ZA 200306615A ZA 200306615 B ZA200306615 B ZA 200306615B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- phenoxy
- pyrimidine
- piperazin
- trione
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 24
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical class O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 title description 8
- 238000004519 manufacturing process Methods 0.000 title description 3
- 239000008177 pharmaceutical agent Substances 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 57
- 239000000203 mixture Substances 0.000 claims description 21
- -1 phenoxy , phenylthio, phenylsulfinyl Chemical group 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 8
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 4
- 125000004193 piperazinyl group Chemical group 0.000 claims description 4
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- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
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- WWUGRHZTCLFLMF-UHFFFAOYSA-N 5-[4-(4-bromophenoxy)phenyl]-5-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethylamino]-1,3-diazinane-2,4,6-trione Chemical compound C1=CC(Br)=CC=C1OC1=CC=C(C2(NCCN3CCN(CC3)C=3N=CC=CN=3)C(NC(=O)NC2=O)=O)C=C1 WWUGRHZTCLFLMF-UHFFFAOYSA-N 0.000 claims description 2
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- HHHNRXQVLSNKJX-UHFFFAOYSA-N 5-[4-(3-ethoxy-2-hydroxypropyl)piperazin-1-yl]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione Chemical compound C1CN(CC(O)COCC)CCN1C1(C=2C=CC(OC=3C=CC=CC=3)=CC=2)C(=O)NC(=O)NC1=O HHHNRXQVLSNKJX-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C—CHEMISTRY; METALLURGY
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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Landscapes
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01107714 | 2001-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200306615B true ZA200306615B (en) | 2004-11-25 |
Family
ID=8176973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200306615A ZA200306615B (en) | 2001-03-30 | 2003-08-25 | Pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing them. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6716845B2 (pt) |
| EP (1) | EP1383746A2 (pt) |
| JP (1) | JP2004533425A (pt) |
| KR (1) | KR20030086335A (pt) |
| CN (1) | CN1273454C (pt) |
| AR (1) | AR035800A1 (pt) |
| AU (1) | AU2002302470C1 (pt) |
| BR (1) | BR0208440A (pt) |
| CA (1) | CA2442354A1 (pt) |
| MX (1) | MXPA03008588A (pt) |
| PA (1) | PA8542001A1 (pt) |
| PE (1) | PE20021101A1 (pt) |
| UY (1) | UY27239A1 (pt) |
| WO (1) | WO2002079170A2 (pt) |
| ZA (1) | ZA200306615B (pt) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| GB8726714D0 (en) | 1987-11-14 | 1987-12-16 | Beecham Group Plc | Compounds |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US5239078A (en) | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
| EP0489579B1 (en) | 1990-12-03 | 1995-03-29 | Celltech Therapeutics Limited | Peptidyl derivatives |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| EP1095936B1 (en) | 1995-12-08 | 2004-11-24 | Agouron Pharmaceuticals, Inc. | Intermediates useful for the preparation of metallproteinase inhibitors |
| DE19548624A1 (de) * | 1995-12-23 | 1997-06-26 | Boehringer Mannheim Gmbh | Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19726427A1 (de) * | 1997-06-23 | 1998-12-24 | Boehringer Mannheim Gmbh | Pyrimidin-2,4,6-trion-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| AR033651A1 (es) | 1999-10-01 | 2004-01-07 | Hoffmann La Roche | Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento |
-
2002
- 2002-02-25 US US10/082,907 patent/US6716845B2/en not_active Expired - Fee Related
- 2002-03-26 CA CA002442354A patent/CA2442354A1/en not_active Abandoned
- 2002-03-26 PE PE2002000242A patent/PE20021101A1/es not_active Application Discontinuation
- 2002-03-26 EP EP02730063A patent/EP1383746A2/en not_active Withdrawn
- 2002-03-26 CN CNB028074912A patent/CN1273454C/zh not_active Expired - Fee Related
- 2002-03-26 WO PCT/EP2002/003366 patent/WO2002079170A2/en active Application Filing
- 2002-03-26 JP JP2002577797A patent/JP2004533425A/ja active Pending
- 2002-03-26 KR KR10-2003-7012814A patent/KR20030086335A/ko not_active Application Discontinuation
- 2002-03-26 BR BR0208440-6A patent/BR0208440A/pt not_active IP Right Cessation
- 2002-03-26 MX MXPA03008588A patent/MXPA03008588A/es active IP Right Grant
- 2002-03-26 AU AU2002302470A patent/AU2002302470C1/en not_active Ceased
- 2002-03-27 PA PA20028542001A patent/PA8542001A1/es unknown
- 2002-03-27 AR ARP020101143A patent/AR035800A1/es unknown
- 2002-03-27 UY UY27239A patent/UY27239A1/es not_active Application Discontinuation
-
2003
- 2003-08-25 ZA ZA200306615A patent/ZA200306615B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1273454C (zh) | 2006-09-06 |
| PE20021101A1 (es) | 2003-02-13 |
| JP2004533425A (ja) | 2004-11-04 |
| AR035800A1 (es) | 2004-07-14 |
| CA2442354A1 (en) | 2002-10-10 |
| KR20030086335A (ko) | 2003-11-07 |
| US6716845B2 (en) | 2004-04-06 |
| WO2002079170A2 (en) | 2002-10-10 |
| PA8542001A1 (es) | 2002-10-28 |
| WO2002079170A3 (en) | 2003-11-27 |
| AU2002302470C1 (en) | 2008-07-24 |
| US20020187991A1 (en) | 2002-12-12 |
| CN1553901A (zh) | 2004-12-08 |
| UY27239A1 (es) | 2002-09-30 |
| EP1383746A2 (en) | 2004-01-28 |
| MXPA03008588A (es) | 2003-12-08 |
| BR0208440A (pt) | 2004-03-30 |
| AU2002302470B2 (en) | 2008-02-14 |
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