AR035800A1 - Pirimidin-2,4,6-trionas 5,5-disustituidas, composiciones farmaceuticas que las comprenden, y el uso de dichos compuestos en la preparacion de medicamentos - Google Patents

Pirimidin-2,4,6-trionas 5,5-disustituidas, composiciones farmaceuticas que las comprenden, y el uso de dichos compuestos en la preparacion de medicamentos

Info

Publication number
AR035800A1
AR035800A1 ARP020101143A ARP020101143A AR035800A1 AR 035800 A1 AR035800 A1 AR 035800A1 AR P020101143 A ARP020101143 A AR P020101143A AR P020101143 A ARP020101143 A AR P020101143A AR 035800 A1 AR035800 A1 AR 035800A1
Authority
AR
Argentina
Prior art keywords
compounds
substituted
groups
atoms
trionas
Prior art date
Application number
ARP020101143A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR035800A1 publication Critical patent/AR035800A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pirimidin-2,4,6-trionas 5,5-disustituidas de fórmula (1) en donde R1 representa un radical de fenilo, fenoxilo, feniltio, fenilsulfinilo, fenilsulfonilo, fenilamino o fenilmetilo, en donde la fracción de fenilo puede estar sustituida por uno o más átomos de halógeno, alcoxi, alquilo de C1-6, ciano, o grupos nitro, prefiriéndose sustituciones en posición para y/o meta por uno a dos sustituyentes; R2 representa hidrógeno; R3 representa hidrógeno, alquilo inferior, opcionalmente interrumpido por uno o más átomos de O, N o S y opcionalmente e independientemente entre sí sustituidos por uno o más grupos hidroxilo y grupos oxo; R4 representa alquilo inferior, opcionalmente interrumpido por uno o más átomos de O, N o S e independientemente uno de otro sustituido por uno o más grupos de hidroxilo y oxo, arilo, aralquilo, hetarilo o un grupo acilo; R2 y R3 o R3 y R4 junto con el átomo de nitrógeno al que están enlazados pueden formar también un anillo de piperacina que en el último caso puede ser sustituido en el segundo átomo de nitrógeno por arilo, aralquilo o un grupo hetarilo; así como también sus profármacos y sales farmacéuticamente aceptables. Dichos compuestos exhiben actividad inhibidora de metaloproteinasa, y son útiles en el tratamiento de tumores y metástasis. También se dan a conocer composiciones farmacéuticas que comprenden dichos compuestos y el uso de tales compuestos en la preparación de medicamentos
ARP020101143A 2001-03-30 2002-03-27 Pirimidin-2,4,6-trionas 5,5-disustituidas, composiciones farmaceuticas que las comprenden, y el uso de dichos compuestos en la preparacion de medicamentos AR035800A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01107714 2001-03-30

Publications (1)

Publication Number Publication Date
AR035800A1 true AR035800A1 (es) 2004-07-14

Family

ID=8176973

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101143A AR035800A1 (es) 2001-03-30 2002-03-27 Pirimidin-2,4,6-trionas 5,5-disustituidas, composiciones farmaceuticas que las comprenden, y el uso de dichos compuestos en la preparacion de medicamentos

Country Status (15)

Country Link
US (1) US6716845B2 (es)
EP (1) EP1383746A2 (es)
JP (1) JP2004533425A (es)
KR (1) KR20030086335A (es)
CN (1) CN1273454C (es)
AR (1) AR035800A1 (es)
AU (1) AU2002302470C1 (es)
BR (1) BR0208440A (es)
CA (1) CA2442354A1 (es)
MX (1) MXPA03008588A (es)
PA (1) PA8542001A1 (es)
PE (1) PE20021101A1 (es)
UY (1) UY27239A1 (es)
WO (1) WO2002079170A2 (es)
ZA (1) ZA200306615B (es)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8726714D0 (en) 1987-11-14 1987-12-16 Beecham Group Plc Compounds
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5239078A (en) 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
DE69108363T2 (de) 1990-12-03 1995-08-31 Celltech Ltd Peptidylderivate.
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
US5789434A (en) 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
ES2195034T3 (es) 1995-12-08 2003-12-01 Agouron Pharma Inhibidor de metaloproteinasas, composicion farmaceutica que contiene este inhibidor y su utilizacion farmaceutica, y procedimientos que sirven para su preparacion.
DE19548624A1 (de) 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19726427A1 (de) * 1997-06-23 1998-12-24 Boehringer Mannheim Gmbh Pyrimidin-2,4,6-trion-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6350786B1 (en) 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
PE20010659A1 (es) 1999-10-01 2001-06-20 Hoffmann La Roche Derivados de las pirimidin-2,4,6-trionas como inhibidores de metaloproteasas

Also Published As

Publication number Publication date
AU2002302470B2 (en) 2008-02-14
PA8542001A1 (es) 2002-10-28
UY27239A1 (es) 2002-09-30
ZA200306615B (en) 2004-11-25
PE20021101A1 (es) 2003-02-13
MXPA03008588A (es) 2003-12-08
US6716845B2 (en) 2004-04-06
CA2442354A1 (en) 2002-10-10
EP1383746A2 (en) 2004-01-28
CN1273454C (zh) 2006-09-06
CN1553901A (zh) 2004-12-08
US20020187991A1 (en) 2002-12-12
BR0208440A (pt) 2004-03-30
JP2004533425A (ja) 2004-11-04
KR20030086335A (ko) 2003-11-07
WO2002079170A3 (en) 2003-11-27
AU2002302470C1 (en) 2008-07-24
WO2002079170A2 (en) 2002-10-10

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