ZA200304411B - Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens. - Google Patents

Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens. Download PDF

Info

Publication number
ZA200304411B
ZA200304411B ZA200304411A ZA200304411A ZA200304411B ZA 200304411 B ZA200304411 B ZA 200304411B ZA 200304411 A ZA200304411 A ZA 200304411A ZA 200304411 A ZA200304411 A ZA 200304411A ZA 200304411 B ZA200304411 B ZA 200304411B
Authority
ZA
South Africa
Prior art keywords
composition
treatment
gangliosides
substance
outer membrane
Prior art date
Application number
ZA200304411A
Other languages
English (en)
Inventor
Luis Enrique Fernandez Molina
Eduardo Raul Suarez Pestana
Circe Mesa Pardillo
Yildian Diaz Rodriquez
Belinda Sanchez Ramirez
Anabel De La Barrera Aira
Joel De Leon Delgado
Rolando Perez Rodriguez
Original Assignee
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CU20000285A external-priority patent/CU23000A1/es
Priority claimed from CU20010167A external-priority patent/CU23009A1/es
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Publication of ZA200304411B publication Critical patent/ZA200304411B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588Adjuvants of undefined constitution
    • A61K2039/55594Adjuvants of undefined constitution from bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6081Albumin; Keyhole limpet haemocyanin [KLH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
ZA200304411A 2000-12-06 2003-06-05 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens. ZA200304411B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU20000285A CU23000A1 (es) 2000-12-06 2000-12-06 Composiciones vacunales para la inmunoterapia activa específica del cáncer
CU20010167A CU23009A1 (es) 2001-07-12 2001-07-12 Preparaciones para potenciar la inmunogenicidad depreparaciones para potenciar la inmunogenicidad de antígenos poco inmunogénicos antígenos poco inmunogénicos

Publications (1)

Publication Number Publication Date
ZA200304411B true ZA200304411B (en) 2004-07-29

Family

ID=38812545

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200304411A ZA200304411B (en) 2000-12-06 2003-06-05 Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens.

Country Status (20)

Country Link
US (1) US7776342B2 (da)
EP (1) EP1356822B1 (da)
JP (1) JP4210519B2 (da)
KR (1) KR100850473B1 (da)
CN (1) CN1291755C (da)
AR (1) AR031638A1 (da)
AT (1) ATE485833T1 (da)
AU (2) AU2151902A (da)
BR (1) BRPI0116013B8 (da)
CA (1) CA2431188C (da)
DE (1) DE60143363D1 (da)
DK (1) DK1356822T3 (da)
EA (1) EA005138B1 (da)
HK (1) HK1063726A1 (da)
MX (1) MXPA03005032A (da)
NZ (1) NZ526282A (da)
PE (1) PE20020572A1 (da)
UY (1) UY27059A1 (da)
WO (1) WO2002045746A2 (da)
ZA (1) ZA200304411B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1367395A1 (de) * 2002-05-02 2003-12-03 B.R.A.H.M.S Aktiengesellschaft Diagnose von Neoplasmen mit Hilfe von anti-Gangliosid-Antikörpern
EP1358910A1 (de) * 2002-05-02 2003-11-05 B.R.A.H.M.S Aktiengesellschaft Verfahren und Mittel zur Prävention, Hemmung und Therapie von Krebserkrankungen
CU23257A1 (es) * 2003-02-27 2008-01-24 Centro Inmunologia Molecular COMPOSICIONES VACUNALES A BASE DE GANGLIOSIDOS PARA LA ADMINISTRACION SUBCUTáNEA
AR045815A1 (es) * 2003-10-09 2005-11-16 Ct Ingenieria Genetica Biotech Composiciones farmaceuticas que contienen antigenos del virus de papiloma humano
US8147840B2 (en) * 2004-05-14 2012-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human immunodeficiency virus (HIV) immunization strategies employing conformationally-stabilized, surface-occluded peptides comprising a gp41 2F5 epitope in association with lipid
WO2010003219A1 (en) * 2008-06-17 2010-01-14 Universite Laval Compositions comprising salmonella porins and uses thereof as adjuvants and vaccines
US20130295167A1 (en) * 2010-12-22 2013-11-07 Bayer Intellectual Property Gmbh Enhanced immune response in bovine species
KR101323845B1 (ko) * 2011-01-21 2013-10-31 광주과학기술원 외막소포체를 유효성분으로 포함하는 항암용 약제학적 조성물
CU24070B1 (es) * 2011-12-27 2015-01-29 Ct De Inmunología Molecular Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3)
CA2904506A1 (en) * 2013-03-15 2014-09-18 Bioven 3 Limited Self-assembling synthetic proteins
CU24299B1 (es) * 2013-08-02 2017-12-08 Centro De Inmunología Molecular Composiciones vacunales bivalentes basadas en los receptores de tipo 1 y 2 del factor de crecimiento epidérmico
US10105306B2 (en) * 2013-09-17 2018-10-23 Bestop Group Holdings Limited Method of preparing a growth factor concentrate
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
JP6609565B2 (ja) * 2014-03-11 2019-11-20 ユニヴェルシテ デクス−マルセイユ 細胞膜ガングリオシドと相互作用するキメラペプチド
EP3597214A1 (en) 2017-03-15 2020-01-22 Centro de Inmunologia Molecular Method for the treatment of patients with carcinomas
AU2018341578B2 (en) * 2017-09-27 2024-02-08 L2 Diagnostics, Llc ErbB peptide pharmaceutical and vaccine compositions and therapeutics uses thereof for cancer
CU24534B1 (es) * 2017-11-06 2021-07-02 Ct Inmunologia Molecular Adyuvantes nano-particulados que contienen variantes sintéticas del gangliósido gm3
CU20170173A7 (es) * 2017-12-27 2019-11-04 Ct Inmunologia Molecular Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras
CN109865137A (zh) * 2019-01-23 2019-06-11 天德悦(北京)生物科技有限责任公司 经碘代乙酰基活化的琼脂糖微球在提高多肽或蛋白类免疫原免疫原性中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857637A (en) * 1986-05-07 1989-08-15 Genentech, Inc. Methods and compositions for immunologically modulating growth hormone receptor activity
IT1206250B (it) * 1987-02-18 1989-04-14 Ist Farmacoterapico It Spa Stiche umane e relativi prodotti metodo per l'estrazione di antigeni di membrana aventi proprieta' immunogene a partire da cellule neopla-
US5726292A (en) * 1987-06-23 1998-03-10 Lowell; George H. Immuno-potentiating systems for preparation of immunogenic materials
US5679356A (en) 1992-07-08 1997-10-21 Schering Corporation Use of GM-CSF as a vaccine adjuvant
EP0657471B1 (en) * 1993-12-09 2001-10-24 Centro de Inmunologia Molecular Anti ganglioside monoclonal antibodies and their use in the specific active immunotherapy of malignant tumours
CU22420A1 (es) 1993-12-29 1996-01-31 Centro Inmunologia Molecular Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer
US6149921A (en) * 1993-12-29 2000-11-21 Centro De Inmunologia Molecular Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AU737330B2 (en) * 1998-01-16 2001-08-16 Biomira Usa Inc. Patient-specific white blood cell malignancy vaccine from membrane-proteoliposomes

Also Published As

Publication number Publication date
CA2431188C (en) 2010-09-07
EP1356822A2 (en) 2003-10-29
BR0116013A (pt) 2004-01-06
JP2004523494A (ja) 2004-08-05
DK1356822T3 (da) 2011-02-07
ATE485833T1 (de) 2010-11-15
US7776342B2 (en) 2010-08-17
KR20030061838A (ko) 2003-07-22
US20020136735A1 (en) 2002-09-26
CN1484532A (zh) 2004-03-24
WO2002045746A2 (es) 2002-06-13
MXPA03005032A (es) 2004-09-10
BRPI0116013B1 (pt) 2018-07-24
HK1063726A1 (en) 2005-01-14
AU2002221519B2 (en) 2006-11-23
WO2002045746A3 (es) 2002-12-27
DE60143363D1 (de) 2010-12-09
JP4210519B2 (ja) 2009-01-21
CA2431188A1 (en) 2002-06-13
CN1291755C (zh) 2006-12-27
KR100850473B1 (ko) 2008-08-07
EP1356822B1 (en) 2010-10-27
PE20020572A1 (es) 2002-07-31
NZ526282A (en) 2005-01-28
EA005138B1 (ru) 2004-12-30
AR031638A1 (es) 2003-09-24
AU2151902A (en) 2002-06-18
BRPI0116013B8 (pt) 2021-05-25
UY27059A1 (es) 2002-04-26
EA200300640A1 (ru) 2003-12-25

Similar Documents

Publication Publication Date Title
US7776342B2 (en) Preparations that potentiate immunogenicity in low immunogenic antigens
KR101323540B1 (ko) 암의 치료제
JP4713638B2 (ja) ナチュラルキラーt細胞のリガンドと抗原を積載したb細胞を媒介とするワクチン
JP5519477B2 (ja) T1免疫応答とt2免疫応答との間で調節するためのワクチン
JP2004523494A6 (ja) 低免疫原性抗原の免疫原性を増強する医薬組成物
US20240131152A1 (en) Nano-particles that contain synthetic variants of gm3 ganglioside as adjuvants in vaccines
EP1660040A1 (en) In vivo targeting of dendritic cells
CA2391927A1 (en) Novel use of antibodies as vaccines
AU2002309141A1 (en) Vaccine for modulating between T1 and T2 immune responses
ES2353857T3 (es) Composiciones farmacéuticas que mejoran la inmunogenicidad de antígenos poco inmunogénicos.
Kinzler et al. Cancer vaccines
EA042396B1 (ru) Наночастицы, содержащие синтетические варианты ганглиозида gm3, в качестве адъювантов в вакцинах
Lee Activation of CD8+ Cytotoxic T Lymphocytes against Tumor Cells using a TLRL-MUC1-Tn Cancer Vaccine