ZA200304194B - Combination therapy comprising anti-diabetic and anti-convulsant agents. - Google Patents
Combination therapy comprising anti-diabetic and anti-convulsant agents. Download PDFInfo
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- ZA200304194B ZA200304194B ZA200304194A ZA200304194A ZA200304194B ZA 200304194 B ZA200304194 B ZA 200304194B ZA 200304194 A ZA200304194 A ZA 200304194A ZA 200304194 A ZA200304194 A ZA 200304194A ZA 200304194 B ZA200304194 B ZA 200304194B
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- South Africa
- Prior art keywords
- compound
- formula
- insulin
- diabetic agent
- mammals
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- 239000003472 antidiabetic agent Substances 0.000 title claims abstract description 42
- 229940125708 antidiabetic agent Drugs 0.000 title claims abstract description 40
- 239000001961 anticonvulsive agent Substances 0.000 title abstract description 7
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- 230000003178 anti-diabetic effect Effects 0.000 title description 3
- 229940125681 anticonvulsant agent Drugs 0.000 title description 3
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 14
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 13
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
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| ZA200304194A ZA200304194B (en) | 2000-10-30 | 2003-05-29 | Combination therapy comprising anti-diabetic and anti-convulsant agents. |
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| TW (1) | TWI239840B (da) |
| WO (1) | WO2002064210A2 (da) |
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| US20080255093A1 (en) * | 1999-06-14 | 2008-10-16 | Tam Peter Y | Compositions and methods for treating obesity and related disorders |
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| US20080103179A1 (en) * | 2006-10-27 | 2008-05-01 | Tam Peter Y | Combination Therapy |
| WO2002080936A1 (en) * | 2001-04-04 | 2002-10-17 | Ortho Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and ppar modulators |
| JP4590158B2 (ja) * | 2001-04-04 | 2010-12-01 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | グルコース再吸収阻害剤およびレチノイド−ｘ受容体モジュレーターを含んで成る併用療法 |
| EP2301537A1 (en) | 2002-05-17 | 2011-03-30 | Duke University | Zonisamide for the treatment of obesity |
| US20040077679A1 (en) * | 2002-07-29 | 2004-04-22 | Cincotta Anthony H. | Therapeutic treatment for the metabolic syndrome and type 2 diabetes |
| CA2518465A1 (en) | 2003-03-25 | 2004-10-14 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
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| JP2007511467A (ja) | 2003-05-14 | 2007-05-10 | タケダ サン ディエゴ インコーポレイテッド | ジペプチジルペプチダーゼインヒビター |
| DE60331236D1 (de) * | 2003-07-24 | 2010-03-25 | Eswaran Krishnan Iyer | Orale zusammensetzungen zur behandlung von diabetes |
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| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP1697342A2 (en) * | 2003-09-08 | 2006-09-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP1699777B1 (en) | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| JP2007517901A (ja) * | 2004-01-13 | 2007-07-05 | デューク・ユニバーシティー | 体重の減少に作用する鎮痙剤及び抗精神病剤の組成物 |
| US7713959B2 (en) * | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN102140090A (zh) | 2004-03-15 | 2011-08-03 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| CA2565154A1 (en) * | 2004-05-03 | 2005-11-24 | Duke University | Compositions for affecting weight loss |
| WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US8394765B2 (en) * | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| CN101094689B (zh) * | 2004-11-01 | 2013-06-12 | 安米林药品有限责任公司 | 治疗肥胖以及肥胖相关疾病和病症的方法 |
| US7872124B2 (en) | 2004-12-21 | 2011-01-18 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| AU2006278575A1 (en) * | 2005-08-04 | 2007-02-15 | Merck & Co., Inc. | Aminoethane sulfonamide orexin receptor antagonists |
| PT1922430T (pt) * | 2005-09-08 | 2019-04-12 | Erasteel Kloster Ab | Aço rápido fabricado por pulverometalurgia |
| MY159522A (en) * | 2005-09-14 | 2017-01-13 | Takeda Pharmaceuticals Co | Administration of dipeptidyl peptidase inhibitors |
| EA015169B1 (ru) | 2005-09-14 | 2011-06-30 | Такеда Фармасьютикал Компани Лимитед | Применение ингибиторов дипептидилпептидазы |
| PE20070622A1 (es) * | 2005-09-14 | 2007-08-22 | Takeda Pharmaceutical | Administracion de inhibidores de dipeptidil peptidasa |
| TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
| EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
| EP2135603B1 (en) | 2005-11-22 | 2013-01-02 | Orexigen Therapeutics, Inc. | Compositions and methods for increasing insulin sensitivity |
| US20100029941A1 (en) * | 2006-03-28 | 2010-02-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
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| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
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| KR20090088854A (ko) * | 2006-09-13 | 2009-08-20 | 다케다 야쿠힌 고교 가부시키가이샤 | 2-6-(3-아미노-피페리딘-엘-일)-3-메틸-2,4-디옥소-3,4-디하이드로-2h-피리미딘-1-일메틸-4-플루오로-벤조니트릴의 용도 |
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| KR20190042766A (ko) | 2006-11-09 | 2019-04-24 | 오렉시젠 세러퓨틱스 인크. | 신속하게 용해되는 중간층을 포함하는 층상의 약제학적 제형 |
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| US11241420B2 (en) * | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
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2001
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- 2001-10-25 NZ NZ537490A patent/NZ537490A/en unknown
- 2001-10-25 AT AT01270165T patent/ATE334718T1/de active
- 2001-10-25 EP EP01270165A patent/EP1333887B1/en not_active Expired - Lifetime
- 2001-10-25 PT PT01270165T patent/PT1333887E/pt unknown
- 2001-10-25 US US10/042,425 patent/US6686337B2/en not_active Expired - Lifetime
- 2001-10-25 WO PCT/US2001/050840 patent/WO2002064210A2/en active IP Right Grant
- 2001-10-25 DE DE60121988T patent/DE60121988T2/de not_active Expired - Lifetime
- 2001-10-25 JP JP2002564002A patent/JP2004518718A/ja active Pending
- 2001-10-25 AU AU2002253838A patent/AU2002253838B2/en not_active Ceased
- 2001-10-25 MX MXPA03003870A patent/MXPA03003870A/es active IP Right Grant
- 2001-10-25 DK DK01270165T patent/DK1333887T3/da active
- 2001-10-25 RU RU2003112618/14A patent/RU2003112618A/ru not_active Application Discontinuation
- 2001-10-25 ES ES01270165T patent/ES2269297T3/es not_active Expired - Lifetime
- 2001-10-30 TW TW090126821A patent/TWI239840B/zh not_active IP Right Cessation
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|---|---|
| EP1333887B1 (en) | 2006-08-02 |
| US20040157785A1 (en) | 2004-08-12 |
| AU2002253838B2 (en) | 2006-11-09 |
| EP1333887A2 (en) | 2003-08-13 |
| NZ537490A (en) | 2006-11-30 |
| US6686337B2 (en) | 2004-02-03 |
| BR0115055A (pt) | 2003-12-30 |
| JP2004518718A (ja) | 2004-06-24 |
| ES2269297T3 (es) | 2007-04-01 |
| US20020147157A1 (en) | 2002-10-10 |
| ATE334718T1 (de) | 2006-08-15 |
| PT1333887E (pt) | 2006-10-31 |
| TWI239840B (en) | 2005-09-21 |
| WO2002064210A2 (en) | 2002-08-22 |
| WO2002064210A3 (en) | 2003-03-06 |
| DK1333887T3 (da) | 2006-11-13 |
| CY1106195T1 (el) | 2011-06-08 |
| DE60121988D1 (de) | 2006-09-14 |
| RU2003112618A (ru) | 2004-09-27 |
| MXPA03003870A (es) | 2004-08-12 |
| DE60121988T2 (de) | 2007-02-15 |
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