ZA200303557B - Intraocular irrigating solution having improved flow characteristics - Google Patents
Intraocular irrigating solution having improved flow characteristics Download PDFInfo
- Publication number
- ZA200303557B ZA200303557B ZA2003/03557A ZA200303557A ZA200303557B ZA 200303557 B ZA200303557 B ZA 200303557B ZA 2003/03557 A ZA2003/03557 A ZA 2003/03557A ZA 200303557 A ZA200303557 A ZA 200303557A ZA 200303557 B ZA200303557 B ZA 200303557B
- Authority
- ZA
- South Africa
- Prior art keywords
- solution
- viscosity
- concentration
- adjusting agent
- hydroxypropyl methylcellulose
- Prior art date
Links
- 239000013010 irrigating solution Substances 0.000 title claims abstract description 39
- 239000000243 solution Substances 0.000 claims abstract description 47
- 238000001356 surgical procedure Methods 0.000 claims abstract description 29
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 45
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 45
- 239000000203 mixture Substances 0.000 claims description 22
- 239000003855 balanced salt solution Substances 0.000 claims description 21
- 239000004034 viscosity adjusting agent Substances 0.000 claims description 21
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 17
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 229940113601 irrigation solution Drugs 0.000 claims description 10
- 102000008186 Collagen Human genes 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 8
- 229920001436 collagen Polymers 0.000 claims description 8
- 229920002678 cellulose Polymers 0.000 claims description 7
- 239000001913 cellulose Substances 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 229920000926 Galactomannan Polymers 0.000 claims description 5
- 229920002148 Gellan gum Polymers 0.000 claims description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 102000016611 Proteoglycans Human genes 0.000 claims description 4
- 108010067787 Proteoglycans Proteins 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 239000003792 electrolyte Substances 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims description 4
- 238000003287 bathing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 abstract description 24
- 229940082649 blood substitutes and perfusion irrigating solutions Drugs 0.000 abstract description 23
- 239000012634 fragment Substances 0.000 abstract description 21
- 210000001742 aqueous humor Anatomy 0.000 abstract description 13
- 230000006378 damage Effects 0.000 abstract description 7
- 210000000695 crystalline len Anatomy 0.000 description 17
- 239000003795 chemical substances by application Substances 0.000 description 12
- 230000002262 irrigation Effects 0.000 description 12
- 238000003973 irrigation Methods 0.000 description 12
- 230000000694 effects Effects 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 210000000399 corneal endothelial cell Anatomy 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000008151 electrolyte solution Substances 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 239000008389 polyethoxylated castor oil Substances 0.000 description 4
- 239000003190 viscoelastic substance Substances 0.000 description 4
- 208000002177 Cataract Diseases 0.000 description 3
- 239000006172 buffering agent Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000008215 water for injection Substances 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 210000000871 endothelium corneal Anatomy 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000000541 pulsatile effect Effects 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 230000002207 retinal effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000012929 tonicity agent Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 101100245267 Caenorhabditis elegans pas-1 gene Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 1
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 description 1
- 210000002159 anterior chamber Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- -1 hydroxypropyl Chemical group 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000037974 severe injury Diseases 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- AYRVGWHSXIMRAB-UHFFFAOYSA-M sodium acetate trihydrate Chemical compound O.O.O.[Na+].CC([O-])=O AYRVGWHSXIMRAB-UHFFFAOYSA-M 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 231100000094 tissue damage in the eye Toxicity 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25757000P | 2000-12-20 | 2000-12-20 | |
| PCT/US2001/048094 WO2002049614A2 (en) | 2000-12-20 | 2001-12-11 | Intraocular irrigating solution having improved flow characteristics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200303557B true ZA200303557B (en) | 2005-05-25 |
Family
ID=22976822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2003/03557A ZA200303557B (en) | 2000-12-20 | 2003-05-08 | Intraocular irrigating solution having improved flow characteristics |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20050148542A1 (enExample) |
| EP (1) | EP1343474B1 (enExample) |
| JP (2) | JP2005502581A (enExample) |
| KR (2) | KR100767159B1 (enExample) |
| AT (1) | ATE459337T1 (enExample) |
| AU (2) | AU2002239601B2 (enExample) |
| BR (1) | BR0116353A (enExample) |
| CA (1) | CA2431368C (enExample) |
| CY (1) | CY1110703T1 (enExample) |
| DE (1) | DE60141477D1 (enExample) |
| DK (1) | DK1343474T3 (enExample) |
| ES (1) | ES2339745T3 (enExample) |
| PT (1) | PT1343474E (enExample) |
| TW (1) | TWI290050B (enExample) |
| WO (1) | WO2002049614A2 (enExample) |
| ZA (1) | ZA200303557B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7914803B2 (en) * | 2003-06-13 | 2011-03-29 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of three polymers |
| US7947295B2 (en) | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| CA2527712C (en) * | 2003-06-13 | 2014-08-05 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| US8748402B2 (en) | 2004-06-07 | 2014-06-10 | Bausch & Lomb Pharma Holdings Corp. | Ophthalmic formulations and uses thereof |
| US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
| AR062046A1 (es) * | 2006-07-25 | 2008-08-10 | Osmotica Pharmaceutical Argentina S A | Soluciones oftalmicas |
| CN105664136A (zh) * | 2008-05-07 | 2016-06-15 | 加利福尼亚大学董事会 | 眼表润滑的治疗性补充和富集 |
| AU2011237671B2 (en) * | 2010-04-09 | 2014-04-24 | National Health Research Institutes | Gamma-polyglutamic acid-based ocular irrigating solutions |
| JP6588491B2 (ja) * | 2017-03-27 | 2019-10-09 | 東邦瓦斯株式会社 | 潜熱蓄熱材の蓄熱槽内配置方法、及び潜熱蓄熱槽 |
| JP7243549B2 (ja) * | 2019-09-24 | 2023-03-22 | 日油株式会社 | ソフトコンタクトレンズ用タンパク質付着抑制剤およびソフトコンタクトレンズ用溶液、ならびにソフトコンタクトレンズに対するタンパク質の付着を抑制する方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4120949A (en) * | 1977-10-05 | 1978-10-17 | Cooper Laboratories, Inc. | Ophthalmic solution |
| US4328482A (en) * | 1977-11-17 | 1982-05-04 | Consumer Electronic Products Corporation | Remote AC power control with control pulses at the zero crossing of the AC wave |
| US4271143A (en) * | 1978-01-25 | 1981-06-02 | Alcon Laboratories, Inc. | Sustained release ophthalmic drug dosage |
| US4238482A (en) * | 1978-09-29 | 1980-12-09 | Peyman Gholam A | Intraocular infusion irrigation solution and method |
| US4255415A (en) * | 1978-11-22 | 1981-03-10 | Schering Corporation | Polyvinyl alcohol ophthalmic gel |
| JPS5929616A (ja) * | 1982-08-10 | 1984-02-16 | Kaken Pharmaceut Co Ltd | 抗炎症眼科用液剤およびその製法 |
| US5409904A (en) * | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| US4886786A (en) * | 1985-08-01 | 1989-12-12 | Lindstrom Richard L | Additive for irrigation solution or surgical solution |
| FR2588189B1 (fr) * | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| CA1317226C (en) * | 1987-05-04 | 1993-05-04 | Phillip E. Pennell | Viscoelastic fluid for ophthalmic surgery and method of using same |
| US5068225A (en) * | 1987-05-04 | 1991-11-26 | Mdr Group, Inc. | Viscoelastic fluid for use in surgery and other therapies and method of using same |
| US4983585A (en) * | 1987-05-04 | 1991-01-08 | Mdr Group, Inc. | Viscoelastic fluid for use in surgery and other therapies and method of using same |
| US6271216B1 (en) * | 1989-07-24 | 2001-08-07 | Allergan | Stable solution of hyaluronate in a balanced salt medium |
| WO1992000745A1 (en) * | 1990-07-03 | 1992-01-23 | Autogenesis Technologies, Inc. | Collagen-based viscoelastic solution for visco-surgery |
| JPH0665061A (ja) * | 1991-06-25 | 1994-03-08 | L Lyndstrom Richard | 洗浄溶液並びに外科用溶液の添加剤 |
| US5328701A (en) * | 1992-09-10 | 1994-07-12 | Peregrine Surgical Ltd. | Tissue irrigation solution |
| US5895645A (en) * | 1995-01-31 | 1999-04-20 | Bausch & Lomb Incorporated | Opthalmic solution for artificial tears |
| EP0938903A4 (en) * | 1996-02-07 | 2000-11-15 | Rohto Pharma | OPHTHALMIC COMPOSITION WITH REGULATED VISCOSITY |
| BR9806626A (pt) * | 1997-03-10 | 2001-03-20 | Galvak S A De C V | Método e aparelho para operar um sistema para galvanizar lâmina de aço |
| ATE391492T1 (de) * | 1997-07-29 | 2008-04-15 | Alcon Lab Inc | Ophthalmische zusammensetzungen enthaltend galaktomannanpolymere und borat |
| US6174524B1 (en) * | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| US7084130B2 (en) * | 2001-12-11 | 2006-08-01 | Alcon, Inc. | Intraocular irrigating solution having improved flow characteristics |
| WO2002049610A2 (en) * | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Ophthalmic irrigating solution adapted for use in lasik surgery |
| AU2002232437A1 (en) * | 2000-12-20 | 2002-07-01 | Alcon Universal Ltd. | Ophthalmic lubricating solution adapted for use in lasik surgery |
-
2001
- 2001-12-11 WO PCT/US2001/048094 patent/WO2002049614A2/en not_active Ceased
- 2001-12-11 KR KR1020037008262A patent/KR100767159B1/ko not_active Expired - Fee Related
- 2001-12-11 JP JP2002550956A patent/JP2005502581A/ja active Pending
- 2001-12-11 PT PT01987379T patent/PT1343474E/pt unknown
- 2001-12-11 ES ES01987379T patent/ES2339745T3/es not_active Expired - Lifetime
- 2001-12-11 AU AU2002239601A patent/AU2002239601B2/en not_active Ceased
- 2001-12-11 CA CA002431368A patent/CA2431368C/en not_active Expired - Lifetime
- 2001-12-11 DK DK01987379.3T patent/DK1343474T3/da active
- 2001-12-11 AU AU3960102A patent/AU3960102A/xx active Pending
- 2001-12-11 KR KR1020077017978A patent/KR20070087252A/ko not_active Ceased
- 2001-12-11 BR BR0116353-1A patent/BR0116353A/pt not_active Application Discontinuation
- 2001-12-11 EP EP01987379A patent/EP1343474B1/en not_active Expired - Lifetime
- 2001-12-11 DE DE60141477T patent/DE60141477D1/de not_active Expired - Lifetime
- 2001-12-11 AT AT01987379T patent/ATE459337T1/de active
- 2001-12-19 TW TW090131545A patent/TWI290050B/zh not_active IP Right Cessation
-
2003
- 2003-05-08 ZA ZA2003/03557A patent/ZA200303557B/en unknown
-
2005
- 2005-02-11 US US11/056,042 patent/US20050148542A1/en not_active Abandoned
-
2007
- 2007-10-04 US US11/867,523 patent/US20080020017A1/en not_active Abandoned
-
2008
- 2008-07-08 JP JP2008177713A patent/JP2008308503A/ja active Pending
-
2010
- 2010-03-19 CY CY20101100252T patent/CY1110703T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60141477D1 (de) | 2010-04-15 |
| PT1343474E (pt) | 2010-04-19 |
| WO2002049614A3 (en) | 2003-01-23 |
| JP2005502581A (ja) | 2005-01-27 |
| CY1110703T1 (el) | 2015-06-10 |
| EP1343474A2 (en) | 2003-09-17 |
| BR0116353A (pt) | 2005-04-05 |
| CA2431368C (en) | 2006-08-08 |
| WO2002049614A2 (en) | 2002-06-27 |
| KR20070087252A (ko) | 2007-08-27 |
| CA2431368A1 (en) | 2002-06-27 |
| JP2008308503A (ja) | 2008-12-25 |
| EP1343474B1 (en) | 2010-03-03 |
| TWI290050B (en) | 2007-11-21 |
| ES2339745T3 (es) | 2010-05-25 |
| US20050148542A1 (en) | 2005-07-07 |
| ATE459337T1 (de) | 2010-03-15 |
| DK1343474T3 (da) | 2010-05-17 |
| HK1055251A1 (en) | 2004-01-02 |
| KR20030063441A (ko) | 2003-07-28 |
| KR100767159B1 (ko) | 2007-10-15 |
| AU2002239601B2 (en) | 2005-09-01 |
| AU3960102A (en) | 2002-07-01 |
| US20080020017A1 (en) | 2008-01-24 |
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