ZA200301437B - Vaccine immunogens comprising disulphide bridged cyclised peptide and use thereof in the treatment of allergies. - Google Patents
Vaccine immunogens comprising disulphide bridged cyclised peptide and use thereof in the treatment of allergies. Download PDFInfo
- Publication number
- ZA200301437B ZA200301437B ZA200301437A ZA200301437A ZA200301437B ZA 200301437 B ZA200301437 B ZA 200301437B ZA 200301437 A ZA200301437 A ZA 200301437A ZA 200301437 A ZA200301437 A ZA 200301437A ZA 200301437 B ZA200301437 B ZA 200301437B
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- ZA
- South Africa
- Prior art keywords
- peptide
- peptides
- cyclised
- carrier
- vaccine
- Prior art date
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- 201000010105 allergic rhinitis Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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- 239000004411 aluminium Substances 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
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- 208000010216 atopic IgE responsiveness Diseases 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 159000000007 calcium salts Chemical class 0.000 description 1
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- 239000000539 dimer Substances 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
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- 150000002333 glycines Chemical class 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-M hexanoate Chemical compound CCCCCC([O-])=O FUZZWVXGSFPDMH-UHFFFAOYSA-M 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
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- 125000005462 imide group Chemical group 0.000 description 1
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- 230000003308 immunostimulating effect Effects 0.000 description 1
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- 238000009169 immunotherapy Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
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- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
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- 238000007912 intraperitoneal administration Methods 0.000 description 1
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- 239000003446 ligand Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
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- 229920002521 macromolecule Polymers 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
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- 239000011859 microparticle Substances 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
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- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000863 peptide conjugate Substances 0.000 description 1
- 229940023041 peptide vaccine Drugs 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 235000013930 proline Nutrition 0.000 description 1
- 150000003148 prolines Chemical class 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009959 type I hypersensitivity Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0020717.5A GB0020717D0 (en) | 2000-08-22 | 2000-08-22 | Novel compounds and process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200301437B true ZA200301437B (en) | 2004-05-21 |
Family
ID=9898110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200301437A ZA200301437B (en) | 2000-08-22 | 2003-02-21 | Vaccine immunogens comprising disulphide bridged cyclised peptide and use thereof in the treatment of allergies. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20040030106A1 (fr) |
| EP (1) | EP1311536A2 (fr) |
| JP (1) | JP2004514655A (fr) |
| KR (1) | KR20030062405A (fr) |
| CN (1) | CN1471539A (fr) |
| AR (1) | AR030458A1 (fr) |
| AU (1) | AU2002214951A1 (fr) |
| BR (1) | BR0113439A (fr) |
| CA (1) | CA2420086A1 (fr) |
| GB (1) | GB0020717D0 (fr) |
| HU (1) | HUP0301725A3 (fr) |
| IL (1) | IL154532A0 (fr) |
| MX (1) | MXPA03001631A (fr) |
| NO (1) | NO20030822L (fr) |
| PL (1) | PL365788A1 (fr) |
| WO (1) | WO2002016409A2 (fr) |
| ZA (1) | ZA200301437B (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0026334D0 (en) * | 2000-10-27 | 2000-12-13 | Smithkline Beecham Biolog | Vaccine |
| GB0209878D0 (en) * | 2002-04-30 | 2002-06-05 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2552999A1 (fr) * | 2004-02-02 | 2005-08-18 | Tanox, Inc. | Identification de nouveaux epitopes ige |
| KR101399175B1 (ko) * | 2006-07-21 | 2014-06-19 | 푼다싸웅 지 앙빠루 아 뻬스끼자 두 에스따두 지 싸웅 파울루 - 에피아뻬에에씨뻬 | 항염증성 및 항알레르기성 시클릭 펩티드 |
| MX2009000800A (es) * | 2006-07-21 | 2009-04-16 | Cristalia Prod Quimicos Farm | Peptidos ciclicos anti-inflamatorios y anti-alergicos. |
| JP2009544697A (ja) * | 2006-07-26 | 2009-12-17 | ペプスキャン システムズ ベー．フェー． | 免疫原性化合物及びタンパク質擬態物 |
| BR112012011055A2 (pt) * | 2009-11-16 | 2019-09-24 | Hoffmann La Roche | reagente de calibração metodo para gerar uma curva padrão metodo pata qualificar a concetração de uma proteina metodo para determinar o limite inferior de detecção de um reagente de afinidade de interesse metodo para determinar a sensibilidade do reagente de afinidade de interesse metodo para determinar a faixa dinamica de um reagente de afinidade de interesse metodo para determinar a especialidade de um reagente de afinidade de interesse uso do reagente de calibração e proteinas peptideos metodos e uso |
| PL2458467T3 (pl) | 2010-11-26 | 2014-03-31 | Abb Research Ltd | Sposób i system do monitorowania systemu przemysłowego |
| CN106366160B (zh) * | 2016-10-11 | 2019-06-14 | 厦门大学 | 基于二硫键精准配对构建富含二硫键多肽分子骨架的方法 |
| CN111936856A (zh) * | 2018-04-06 | 2020-11-13 | Sls生物有限公司 | 新型免疫球蛋白e的表位、与其结合的抗体及包括所述抗体的用于分析试料中免疫球蛋白e的试剂盒 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
| CA2047078A1 (fr) * | 1990-07-19 | 1992-01-20 | Steven S. Bondy | Peptides cycliques neutralisant le vih |
| TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
-
2000
- 2000-08-22 GB GBGB0020717.5A patent/GB0020717D0/en not_active Ceased
-
2001
- 2001-08-17 WO PCT/EP2001/009576 patent/WO2002016409A2/fr not_active Application Discontinuation
- 2001-08-17 AU AU2002214951A patent/AU2002214951A1/en not_active Abandoned
- 2001-08-17 IL IL15453201A patent/IL154532A0/xx unknown
- 2001-08-17 HU HU0301725A patent/HUP0301725A3/hu unknown
- 2001-08-17 KR KR10-2003-7002628A patent/KR20030062405A/ko not_active Application Discontinuation
- 2001-08-17 MX MXPA03001631A patent/MXPA03001631A/es unknown
- 2001-08-17 US US10/362,527 patent/US20040030106A1/en not_active Abandoned
- 2001-08-17 BR BR0113439-6A patent/BR0113439A/pt not_active Application Discontinuation
- 2001-08-17 JP JP2002521504A patent/JP2004514655A/ja active Pending
- 2001-08-17 EP EP01983441A patent/EP1311536A2/fr not_active Withdrawn
- 2001-08-17 CA CA002420086A patent/CA2420086A1/fr not_active Abandoned
- 2001-08-17 PL PL01365788A patent/PL365788A1/xx not_active Application Discontinuation
- 2001-08-17 CN CNA018177778A patent/CN1471539A/zh active Pending
- 2001-08-21 AR ARP010103969A patent/AR030458A1/es unknown
-
2003
- 2003-02-21 NO NO20030822A patent/NO20030822L/no not_active Application Discontinuation
- 2003-02-21 ZA ZA200301437A patent/ZA200301437B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0113439A (pt) | 2004-07-06 |
| EP1311536A2 (fr) | 2003-05-21 |
| NO20030822D0 (no) | 2003-02-21 |
| PL365788A1 (en) | 2005-01-10 |
| US20040030106A1 (en) | 2004-02-12 |
| IL154532A0 (en) | 2003-09-17 |
| CA2420086A1 (fr) | 2002-02-28 |
| AU2002214951A1 (en) | 2002-03-04 |
| HUP0301725A3 (en) | 2004-11-29 |
| WO2002016409A2 (fr) | 2002-02-28 |
| WO2002016409A3 (fr) | 2002-08-29 |
| GB0020717D0 (en) | 2000-10-11 |
| CN1471539A (zh) | 2004-01-28 |
| MXPA03001631A (es) | 2004-09-10 |
| JP2004514655A (ja) | 2004-05-20 |
| HUP0301725A2 (hu) | 2003-08-28 |
| AR030458A1 (es) | 2003-08-20 |
| NO20030822L (no) | 2003-03-31 |
| KR20030062405A (ko) | 2003-07-25 |
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