ZA200207995B - Estrogen agonist/antagonist metabolites. - Google Patents
Estrogen agonist/antagonist metabolites. Download PDFInfo
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- ZA200207995B ZA200207995B ZA200207995A ZA200207995A ZA200207995B ZA 200207995 B ZA200207995 B ZA 200207995B ZA 200207995 A ZA200207995 A ZA 200207995A ZA 200207995 A ZA200207995 A ZA 200207995A ZA 200207995 B ZA200207995 B ZA 200207995B
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- South Africa
- Prior art keywords
- phenyl
- metabolite
- pptn
- pharmaceutically acceptable
- och
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
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- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
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- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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Families Citing this family (17)
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US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US7001926B2 (en) | 2000-03-10 | 2006-02-21 | Oxigene, Inc. | Tubulin binding agents and corresponding prodrug constructs |
US7091240B2 (en) | 2000-03-10 | 2006-08-15 | Oxigene, Inc. | Tubulin binding ligands and corresponding prodrug constructs |
CZ20002567A3 (cs) * | 2000-07-11 | 2001-12-12 | Léčiva, A.S. | Tableta vyrobitelná přímým tabletováním, obsahující aktivní látku kyselinu 4-amino-1-hydroxybutyliden-1,1-bisfosfonovou, a způsob její výroby |
EP1192945A3 (fr) * | 2000-09-21 | 2004-03-03 | Pfizer Products Inc. | Utilisation d'un agoniste/antagoniste estrogénique pour traiter l'ostéoarthrite |
AU781168B2 (en) * | 2001-01-26 | 2005-05-12 | Pfizer Products Inc. | Method of treating certain cancers using an estrogen agonist/antagonist |
US7479504B2 (en) * | 2002-01-18 | 2009-01-20 | Merck & Co., Inc. | Edg receptor agonists |
AU2003208516A1 (en) * | 2002-03-14 | 2003-09-22 | Warner-Lambert Company Llc | Method for characterizing metabolites using hydrogen/deuterium exchange |
US20050095241A1 (en) * | 2003-08-26 | 2005-05-05 | Vadlamudi Ratna K. | Estrogen receptor modulators and uses thereof |
US7456214B2 (en) | 2004-05-03 | 2008-11-25 | Baylor University | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
AU2012200714B2 (en) * | 2004-08-13 | 2014-04-17 | Wyeth Llc | Tanaproget derivatives, metabolites, and uses thereof |
PT1778710E (pt) * | 2004-08-13 | 2012-04-12 | Wyeth Llc | Derivados de tanaproget, metabolitos e suas utilizações |
WO2006136944A1 (fr) * | 2005-06-22 | 2006-12-28 | Pfizer Products Inc. | Procede d'hydrogenation stereoselective la preparation de chlorhydrate de cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphtalene |
US7902147B2 (en) | 2007-11-05 | 2011-03-08 | Duke University | Chronic lymphocytic leukemia prognosis and treatment |
TW201043595A (en) * | 2009-03-13 | 2010-12-16 | Organon Nv | Tetrahydronaphthalen-2-ol derivatives |
US9845291B2 (en) | 2014-12-18 | 2017-12-19 | Genentech, Inc. | Estrogen receptor modulators and uses thereof |
WO2017168174A1 (fr) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | Nouvelles formes pharmaceutiques du sildénafil |
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US3522319A (en) * | 1964-01-23 | 1970-07-28 | Ciba Geigy Corp | Phenol substituted tetrahydronaphthalenes useful as estrogenics |
US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
UA51676C2 (uk) | 1995-11-02 | 2002-12-16 | Пфайзер Інк. | (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція |
IL120266A (en) | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
TW442286B (en) | 1996-02-28 | 2001-06-23 | Pfizer | New therapeutic uses of estrogen agonists |
US6358951B1 (en) | 1998-08-21 | 2002-03-19 | Pfizer Inc. | Growth hormone secretagogues |
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- 2001-04-04 US US09/825,980 patent/US6455572B1/en not_active Ceased
- 2001-04-05 PE PE2001000320A patent/PE20011183A1/es not_active Application Discontinuation
- 2001-04-05 UY UY26656A patent/UY26656A1/es not_active Application Discontinuation
- 2001-04-05 AR ARP010101626A patent/AR035330A1/es unknown
- 2001-04-06 TN TNTNSN01052A patent/TNSN01052A1/fr unknown
- 2001-04-09 PA PA20018514901A patent/PA8514901A1/es unknown
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2002
- 2002-09-17 IS IS6549A patent/IS6549A/is unknown
- 2002-09-23 BG BG107137A patent/BG107137A/bg unknown
- 2002-10-02 MA MA26847A patent/MA26890A1/fr unknown
- 2002-10-02 CR CR6766A patent/CR6766A/es not_active Application Discontinuation
- 2002-10-03 NO NO20024767A patent/NO20024767L/no not_active Application Discontinuation
- 2002-10-04 ZA ZA200207995A patent/ZA200207995B/en unknown
- 2002-10-07 HR HR20020802A patent/HRP20020802A2/hr not_active Application Discontinuation
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2003
- 2003-05-30 US US10/448,751 patent/USRE39419E1/en not_active Expired - Fee Related
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