ZA200206038B - Remedies or preventives for pulmonary insufficiency containing diaminotrifluoromethylpyridine derivatives. - Google Patents
Remedies or preventives for pulmonary insufficiency containing diaminotrifluoromethylpyridine derivatives. Download PDFInfo
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- ZA200206038B ZA200206038B ZA200206038A ZA200206038A ZA200206038B ZA 200206038 B ZA200206038 B ZA 200206038B ZA 200206038 A ZA200206038 A ZA 200206038A ZA 200206038 A ZA200206038 A ZA 200206038A ZA 200206038 B ZA200206038 B ZA 200206038B
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- South Africa
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- group
- substituted
- alkyl
- phenyl
- haloalkyl
- Prior art date
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- 230000003449 preventive effect Effects 0.000 title claims description 14
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- OPJBAKXTAPAALK-UHFFFAOYSA-N n-[2-(ethylsulfonylamino)-5-(trifluoromethyl)pyridin-3-yl]-3-fluorobenzamide Chemical compound CCS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C1=CC=CC(F)=C1 OPJBAKXTAPAALK-UHFFFAOYSA-N 0.000 description 1
- GNSRPLZFSMVDMI-UHFFFAOYSA-N n-[2-(methanesulfonamido)-5-(trifluoromethyl)pyridin-3-yl]-2,3-dihydro-1h-indene-5-carboxamide Chemical compound CS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C1=CC=C(CCC2)C2=C1 GNSRPLZFSMVDMI-UHFFFAOYSA-N 0.000 description 1
- MUOWIDVDOSRPCZ-UHFFFAOYSA-N n-[2-(methanesulfonamido)-5-(trifluoromethyl)pyridin-3-yl]-3-(trifluoromethyl)benzamide Chemical compound CS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C1=CC=CC(C(F)(F)F)=C1 MUOWIDVDOSRPCZ-UHFFFAOYSA-N 0.000 description 1
- HLZKWYRERKPMTI-UHFFFAOYSA-N n-[2-(methanesulfonamido)-5-(trifluoromethyl)pyridin-3-yl]-3-thiophen-2-ylprop-2-enamide Chemical compound CS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C=CC1=CC=CS1 HLZKWYRERKPMTI-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000001196 nonadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000005485 noradamantyl group Chemical group 0.000 description 1
- 125000005593 norbornanyl group Chemical group 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002755 pyrazolinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000001422 pyrrolinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
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- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetraline Natural products C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000002769 thiazolinyl group Chemical group 0.000 description 1
- 125000004587 thienothienyl group Chemical group S1C(=CC2=C1C=CS2)* 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229950008558 ulinastatin Drugs 0.000 description 1
- 108010088854 urinastatin Proteins 0.000 description 1
- ODVKSTFPQDVPJZ-UHFFFAOYSA-N urinastatin Chemical compound C1C=CCCC11COC(C=2OC=CC=2)OC1 ODVKSTFPQDVPJZ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000024349 | 2000-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200206038B true ZA200206038B (en) | 2003-08-18 |
Family
ID=18550353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206038A ZA200206038B (en) | 2000-02-01 | 2002-07-29 | Remedies or preventives for pulmonary insufficiency containing diaminotrifluoromethylpyridine derivatives. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6635665B2 (ja) |
| EP (1) | EP1252889B1 (ja) |
| JP (1) | JP4848092B2 (ja) |
| KR (1) | KR100706725B1 (ja) |
| CN (1) | CN1230170C (ja) |
| AU (1) | AU774479B2 (ja) |
| CA (1) | CA2398992C (ja) |
| DE (1) | DE60122111T8 (ja) |
| ES (1) | ES2269343T3 (ja) |
| IL (2) | IL151009A0 (ja) |
| NZ (1) | NZ520376A (ja) |
| RU (1) | RU2253450C2 (ja) |
| TW (1) | TWI293029B (ja) |
| WO (1) | WO2001056570A1 (ja) |
| ZA (1) | ZA200206038B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004040302A1 (ja) * | 2002-10-30 | 2004-05-13 | Ishihara Sangyo Kaisha, Ltd. | ＲＡＰＬ・Ｒａｐ１相互作用制御 |
| EP1898945B1 (en) * | 2005-06-24 | 2012-12-19 | Drugrecure ApS | Airway administration of site-inactivated fviia in inflammatory conditions affecting the respiratory tract |
| JP5443975B2 (ja) * | 2007-04-27 | 2014-03-19 | 富山化学工業株式会社 | 新規なスルホンアミド誘導体またはその塩 |
| JP5584518B2 (ja) | 2009-05-28 | 2014-09-03 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する抗ショック剤 |
| TW201929851A (zh) * | 2017-11-02 | 2019-08-01 | 日商石原產業股份有限公司 | 緩釋性醫藥組成物 |
| RU2020131982A (ru) | 2018-03-01 | 2022-04-01 | Исихара Сангио Кайся, Лтд. | Фармацевтическая композиция, обладающая превосходной стабильностью при хранении |
| EP3970797A4 (en) | 2019-05-15 | 2022-12-28 | Ishihara Sangyo Kaisha, Ltd. | ANHYDROUS CRYSTAL OF N-(2-ETHYLSULFONYLAMINO-5-TRIFLUOROMETHYL-3-PYRIDYL) CYCLOHEXANE MONOSODIUM CARBOXAMIDE |
| PE20240109A1 (es) | 2020-09-29 | 2024-01-22 | Ishihara Sangyo Kaisha | Composicion farmaceutica en estado liquido que exhibe excelente eficacia conservante |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE157969T1 (de) * | 1990-07-10 | 1997-09-15 | Ishihara Sangyo Kaisha | Diaminotrifluoromethylpyrimidinderivate, verfahren zu ihrer herstellung und diese enthaltende phospholipase-a2-inhibitoren |
| US5229403A (en) * | 1990-07-10 | 1993-07-20 | Ishihara Sangyo Kaisha Ltd. | Diaminotrifluoromethylpyridine derivatives and phospholipase A2 inhibitor containing them |
| TW415843B (en) | 1997-02-28 | 2000-12-21 | Ishihara Sangyo Kaisha | Anti-cancer pharmaceutical compositions comprising a diaminotrifluoromethylpyridine derivatives or the pharmaceutically acceptable salts thereof |
-
2001
- 2001-01-29 JP JP2001020057A patent/JP4848092B2/ja not_active Expired - Lifetime
- 2001-01-30 US US10/181,431 patent/US6635665B2/en not_active Expired - Lifetime
- 2001-01-30 ES ES01902668T patent/ES2269343T3/es not_active Expired - Lifetime
- 2001-01-30 AU AU30528/01A patent/AU774479B2/en not_active Ceased
- 2001-01-30 EP EP01902668A patent/EP1252889B1/en not_active Expired - Lifetime
- 2001-01-30 RU RU2002123372/15A patent/RU2253450C2/ru not_active IP Right Cessation
- 2001-01-30 KR KR1020027009852A patent/KR100706725B1/ko not_active IP Right Cessation
- 2001-01-30 CN CNB018042538A patent/CN1230170C/zh not_active Expired - Fee Related
- 2001-01-30 CA CA002398992A patent/CA2398992C/en not_active Expired - Lifetime
- 2001-01-30 WO PCT/JP2001/000616 patent/WO2001056570A1/ja active IP Right Grant
- 2001-01-30 IL IL15100901A patent/IL151009A0/xx active IP Right Grant
- 2001-01-30 NZ NZ520376A patent/NZ520376A/en not_active IP Right Cessation
- 2001-01-30 DE DE60122111T patent/DE60122111T8/de active Active
- 2001-02-01 TW TW090102077A patent/TWI293029B/zh not_active IP Right Cessation
-
2002
- 2002-07-29 ZA ZA200206038A patent/ZA200206038B/en unknown
- 2002-07-31 IL IL151009A patent/IL151009A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1252889B1 (en) | 2006-08-09 |
| NZ520376A (en) | 2005-02-25 |
| RU2253450C2 (ru) | 2005-06-10 |
| JP4848092B2 (ja) | 2011-12-28 |
| AU774479B2 (en) | 2004-07-01 |
| CA2398992A1 (en) | 2001-08-09 |
| WO2001056570A1 (fr) | 2001-08-09 |
| US20030109551A1 (en) | 2003-06-12 |
| CN1396827A (zh) | 2003-02-12 |
| KR20020072576A (ko) | 2002-09-16 |
| DE60122111T2 (de) | 2006-12-07 |
| EP1252889A1 (en) | 2002-10-30 |
| ES2269343T3 (es) | 2007-04-01 |
| IL151009A (en) | 2008-04-13 |
| DE60122111D1 (de) | 2006-09-21 |
| US6635665B2 (en) | 2003-10-21 |
| DE60122111T8 (de) | 2007-04-05 |
| IL151009A0 (en) | 2003-02-12 |
| KR100706725B1 (ko) | 2007-04-12 |
| CN1230170C (zh) | 2005-12-07 |
| TWI293029B (en) | 2008-02-01 |
| EP1252889A4 (en) | 2004-12-15 |
| JP2001288088A (ja) | 2001-10-16 |
| AU3052801A (en) | 2001-08-14 |
| CA2398992C (en) | 2009-11-17 |
| RU2002123372A (ru) | 2004-03-10 |
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