ZA200205161B - Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone. - Google Patents
Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone. Download PDFInfo
- Publication number
- ZA200205161B ZA200205161B ZA200205161A ZA200205161A ZA200205161B ZA 200205161 B ZA200205161 B ZA 200205161B ZA 200205161 A ZA200205161 A ZA 200205161A ZA 200205161 A ZA200205161 A ZA 200205161A ZA 200205161 B ZA200205161 B ZA 200205161B
- Authority
- ZA
- South Africa
- Prior art keywords
- mirtazapine
- gepirone
- combination
- treatment
- composition
- Prior art date
Links
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title claims description 74
- 229960001785 mirtazapine Drugs 0.000 title claims description 73
- 229960000647 gepirone Drugs 0.000 title claims description 68
- QOIGKGMMAGJZNZ-UHFFFAOYSA-N gepirone Chemical compound O=C1CC(C)(C)CC(=O)N1CCCCN1CCN(C=2N=CC=CN=2)CC1 QOIGKGMMAGJZNZ-UHFFFAOYSA-N 0.000 title claims description 68
- 238000011282 treatment Methods 0.000 title claims description 44
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 22
- 208000020401 Depressive disease Diseases 0.000 title claims description 14
- 239000000890 drug combination Substances 0.000 title description 3
- 239000003814 drug Substances 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
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- 238000004519 manufacturing process Methods 0.000 claims description 7
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- XUHLIQGRKRUKPH-ITZCMCNPSA-N 3-(Allylsulphinyl)-L-alanine Chemical compound OC(=O)[C@@H](N)CS(=O)CC=C XUHLIQGRKRUKPH-ITZCMCNPSA-N 0.000 description 1
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- 206010013710 Drug interaction Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
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- 229920002472 Starch Chemical class 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
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- 239000000443 aerosol Substances 0.000 description 1
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- 230000008503 anti depressant like effect Effects 0.000 description 1
- 230000000338 anxiogenic effect Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000022371 chronic pain syndrome Diseases 0.000 description 1
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- 238000011284 combination treatment Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00200189 | 2000-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200205161B true ZA200205161B (en) | 2003-09-29 |
Family
ID=8170928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200205161A ZA200205161B (en) | 2000-01-19 | 2002-06-27 | Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6835728B2 (fr) |
| EP (1) | EP1251854A2 (fr) |
| JP (1) | JP2003520237A (fr) |
| KR (1) | KR20020068404A (fr) |
| CN (1) | CN1223349C (fr) |
| AR (1) | AR027240A1 (fr) |
| AU (1) | AU780817B2 (fr) |
| BR (1) | BR0107721A (fr) |
| CA (1) | CA2396066A1 (fr) |
| CO (1) | CO5261583A1 (fr) |
| HK (1) | HK1047548A1 (fr) |
| HU (1) | HUP0204050A3 (fr) |
| IL (1) | IL150289A0 (fr) |
| MX (1) | MXPA02007095A (fr) |
| NO (1) | NO20023448L (fr) |
| PE (1) | PE20011049A1 (fr) |
| PL (1) | PL356605A1 (fr) |
| RU (1) | RU2268725C2 (fr) |
| SK (1) | SK10552002A3 (fr) |
| WO (1) | WO2001052855A2 (fr) |
| ZA (1) | ZA200205161B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| WO2006023703A2 (fr) * | 2004-08-20 | 2006-03-02 | Cypress Bioscience, Inc. | Methode de traitement de troubles respiratoires lies au sommeil |
| WO2006055854A2 (fr) * | 2004-11-17 | 2006-05-26 | Cypress Bioscience, Inc. | Methodes servant a limiter les effets secondaires d'un traitement par mirtazapine |
| TW200800306A (en) | 2005-09-12 | 2008-01-01 | Wyeth Corp | Sustained-release formulation and uses thereof |
| GT200600416A (es) | 2005-09-12 | 2007-09-20 | Sales salicilato y gentisato de un compuesto de piperazina | |
| GT200600414A (es) | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| EP1792618A1 (fr) * | 2005-11-30 | 2007-06-06 | Rainer Freynhagen | R-mirtazapine pour le traitement de la douleur |
| AU2007253704A1 (en) * | 2006-05-22 | 2007-11-29 | Vanda Pharmaceuticals, Inc. | Treatment for depressive disorders |
| TW200808804A (en) * | 2006-05-22 | 2008-02-16 | Organon Nv | Mirtazapine for the treatment of neuropathic pain |
| WO2008157094A1 (fr) * | 2007-06-13 | 2008-12-24 | Cypress Bioscience, Inc. | Amélioration de la tolérance à la mirtazapine et à un second principe actif par utilisation combinée de ces derniers |
| PL2219603T3 (pl) * | 2007-11-02 | 2014-10-31 | Acrux Dds Pty Ltd | Układ transdermalnego dostarczania |
| US20130064770A1 (en) | 2010-05-28 | 2013-03-14 | Ge Healthcare Limited | Radiolabeled compounds and methods thereof |
| GB201112987D0 (en) | 2011-07-28 | 2011-09-14 | Ge Healthcare Ltd | Novel compound |
| CN108743593B (zh) * | 2018-08-31 | 2019-03-26 | 程世宏 | 一种抗抑郁药物及其口服颗粒剂和制药用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
| US4771053A (en) * | 1987-03-02 | 1988-09-13 | Bristol-Myers Company | Method for alleviation of primary depressive disorders |
| US5114976A (en) * | 1989-01-06 | 1992-05-19 | Norden Michael J | Method for treating certain psychiatric disorders and certain psychiatric symptoms |
| US5011841B1 (en) * | 1989-11-14 | 1994-09-06 | Pfizer | Treatment of depression |
| GB9303968D0 (en) * | 1993-02-26 | 1993-04-14 | Wyeth John & Brother Ltd | 5-ht1a ligands |
| GB9603136D0 (en) * | 1996-02-15 | 1996-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
| ZA982368B (en) * | 1997-03-27 | 1998-09-23 | Akzo Nobel Nv | New therapeutic combinations |
| TW587938B (en) | 1997-03-27 | 2004-05-21 | Akzo Nobel Nv | Pharmaceutical composition for the treatment and/or prophylaxis of psychotic disorder |
-
2001
- 2001-01-15 RU RU2002122084/15A patent/RU2268725C2/ru not_active IP Right Cessation
- 2001-01-15 AU AU25162/01A patent/AU780817B2/en not_active Ceased
- 2001-01-15 MX MXPA02007095A patent/MXPA02007095A/es not_active Application Discontinuation
- 2001-01-15 HU HU0204050A patent/HUP0204050A3/hu unknown
- 2001-01-15 JP JP2001552902A patent/JP2003520237A/ja not_active Withdrawn
- 2001-01-15 KR KR1020027009276A patent/KR20020068404A/ko not_active Application Discontinuation
- 2001-01-15 EP EP01900449A patent/EP1251854A2/fr not_active Withdrawn
- 2001-01-15 CN CNB018038654A patent/CN1223349C/zh not_active Expired - Fee Related
- 2001-01-15 WO PCT/EP2001/000407 patent/WO2001052855A2/fr not_active Application Discontinuation
- 2001-01-15 SK SK1055-2002A patent/SK10552002A3/sk not_active Application Discontinuation
- 2001-01-15 BR BR0107721-0A patent/BR0107721A/pt not_active IP Right Cessation
- 2001-01-15 PL PL01356605A patent/PL356605A1/xx not_active Application Discontinuation
- 2001-01-15 CA CA002396066A patent/CA2396066A1/fr not_active Abandoned
- 2001-01-15 US US10/181,843 patent/US6835728B2/en not_active Expired - Fee Related
- 2001-01-15 IL IL15028901A patent/IL150289A0/xx unknown
- 2001-01-18 PE PE2001000055A patent/PE20011049A1/es not_active Application Discontinuation
- 2001-01-18 CO CO01003479A patent/CO5261583A1/es not_active Application Discontinuation
- 2001-01-18 AR ARP010100214A patent/AR027240A1/es not_active Application Discontinuation
-
2002
- 2002-06-27 ZA ZA200205161A patent/ZA200205161B/en unknown
- 2002-07-18 NO NO20023448A patent/NO20023448L/no not_active Application Discontinuation
- 2002-12-18 HK HK02109168.5A patent/HK1047548A1/zh unknown
-
2004
- 2004-11-22 US US10/996,213 patent/US20050090488A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001052855A2 (fr) | 2001-07-26 |
| PE20011049A1 (es) | 2001-10-18 |
| MXPA02007095A (es) | 2003-04-14 |
| RU2002122084A (ru) | 2004-03-10 |
| AU780817B2 (en) | 2005-04-21 |
| HUP0204050A2 (hu) | 2003-03-28 |
| PL356605A1 (en) | 2004-06-28 |
| HUP0204050A3 (en) | 2004-09-28 |
| HK1047548A1 (zh) | 2003-02-28 |
| AU2516201A (en) | 2001-07-31 |
| CN1395486A (zh) | 2003-02-05 |
| AR027240A1 (es) | 2003-03-19 |
| NO20023448D0 (no) | 2002-07-18 |
| IL150289A0 (en) | 2002-12-01 |
| WO2001052855A8 (fr) | 2002-12-27 |
| US6835728B2 (en) | 2004-12-28 |
| BR0107721A (pt) | 2002-10-01 |
| US20050090488A1 (en) | 2005-04-28 |
| CA2396066A1 (fr) | 2001-07-26 |
| NO20023448L (no) | 2002-09-17 |
| US20030105083A1 (en) | 2003-06-05 |
| WO2001052855A3 (fr) | 2002-01-10 |
| JP2003520237A (ja) | 2003-07-02 |
| CN1223349C (zh) | 2005-10-19 |
| RU2268725C2 (ru) | 2006-01-27 |
| SK10552002A3 (sk) | 2002-12-03 |
| CO5261583A1 (es) | 2003-03-31 |
| EP1251854A2 (fr) | 2002-10-30 |
| KR20020068404A (ko) | 2002-08-27 |
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