ZA200200294B - Corticotropin releasing factor receptor 2 deficient mice and uses thereof. - Google Patents

Corticotropin releasing factor receptor 2 deficient mice and uses thereof.

Info

Publication number
ZA200200294B
ZA200200294B ZA200200294A ZA200200294A ZA200200294B ZA 200200294 B ZA200200294 B ZA 200200294B ZA 200200294 A ZA200200294 A ZA 200200294A ZA 200200294 A ZA200200294 A ZA 200200294A ZA 200200294 B ZA200200294 B ZA 200200294B
Authority
ZA
South Africa
Prior art keywords
factor receptor
deficient mice
releasing factor
corticotropin releasing
corticotropin
Prior art date
Application number
ZA200200294A
Other languages
English (en)
Inventor
Kno-Fen Lee
Tracy L Bale
George W Smith
Wylie Vale
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of ZA200200294B publication Critical patent/ZA200200294B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200200294A 1999-07-15 2002-01-14 Corticotropin releasing factor receptor 2 deficient mice and uses thereof. ZA200200294B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14426199P 1999-07-15 1999-07-15

Publications (1)

Publication Number Publication Date
ZA200200294B true ZA200200294B (en) 2003-04-30

Family

ID=22507801

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200200294A ZA200200294B (en) 1999-07-15 2002-01-14 Corticotropin releasing factor receptor 2 deficient mice and uses thereof.

Country Status (11)

Country Link
US (1) US6353152B1 (fr)
EP (1) EP1196027A4 (fr)
KR (1) KR20020092891A (fr)
CN (1) CN1188031C (fr)
AU (1) AU780829B2 (fr)
CA (1) CA2375943A1 (fr)
IL (1) IL147657A0 (fr)
NZ (1) NZ516611A (fr)
RU (1) RU2251838C2 (fr)
WO (1) WO2001005222A1 (fr)
ZA (1) ZA200200294B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7674463B1 (en) * 1999-07-15 2010-03-09 Research Development Foundation Method of inhibiting angiogenesis by administration of a corticotropin releasing factor receptor 2 agonist
US20040034882A1 (en) * 1999-07-15 2004-02-19 Vale Wylie W. Corticotropin releasing factor receptor 2 deficient mice and uses thereof
IL154553A0 (en) 2001-03-15 2003-09-17 Res Dev Foundation Urocortin-iii and uses thereof
US20030186302A1 (en) * 2002-03-29 2003-10-02 Yixin Wang Colorectal cancer diagnostics
US7348142B2 (en) * 2002-03-29 2008-03-25 Veridex, Lcc Cancer diagnostic panel
US20030194734A1 (en) * 2002-03-29 2003-10-16 Tim Jatkoe Selection of markers
US7473526B2 (en) * 2002-03-29 2009-01-06 Veridex, Llc Breast cancer prognostic portfolio
WO2004033625A2 (fr) * 2002-05-20 2004-04-22 Research Development Foundation Souris a carence d'urocortine et leurs utilisations
AU2003298302A1 (en) * 2002-11-28 2004-06-18 Neurosearch A/S Method for screening for compounds as potential sedatives or anxiolytics
US6923933B2 (en) * 2003-03-21 2005-08-02 Graham Engineering Corp. Take-out device for rotary blow molding machine and method
US20050042212A1 (en) * 2003-07-24 2005-02-24 Nanda Steven A. Method of reducing CRF receptor mRNA
ES2340195T3 (es) * 2005-01-28 2010-05-31 Astellas Pharma Inc. Metodo de seleccion de agente terapeutico para sindrome de colon irritable.
EE200600039A (et) * 2006-12-12 2008-10-15 Tartu Ülikool Transgeenne loommudel patoloogilise ärevuse modelleerimiseks, meetod patoloogilisest ärevusest p?hjustatud haiguste v?i seisundite ravimiseks sobilike ühendite tuvastamiseks ja meetod Wfs1 valgu kasutamiseks sihtmärgina patoloogilise ärevuse vastase
EP2522351B1 (fr) 2007-06-13 2017-09-06 Research Development Foundation Traitement et prévention de tauopathies et de l'amyloïdose de bêta-amyloïde en modulant la signalisation de récepteur CRF
ES2545794T3 (es) 2009-08-28 2015-09-15 Research Development Foundation Análogos de urocortina 2 y usos de los mismos
CA2867567A1 (fr) * 2012-03-20 2013-09-26 The Board Of Trustees Of The Leland Stanford Junior Unversity Modeles animaux non humains de depression et leurs procedes d'utilisation
ES2561728B1 (es) 2014-08-29 2017-01-18 Consejo Superior De Investigaciones Científicas (Csic) Modelo animal no humano para transtornos del espectro autista, ansiedad y/o depresion
CN117143236A (zh) * 2023-08-31 2023-12-01 美康生物科技股份有限公司 一种抗acth抗体及其制备方法、检测试剂盒

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0724637T4 (da) * 1994-06-14 2002-09-16 Neurocrine Biosciences Inc Kortikotropinfrigørende faktor2-receptorer

Also Published As

Publication number Publication date
EP1196027A4 (fr) 2004-12-22
AU6216700A (en) 2001-02-05
RU2002103717A (ru) 2004-03-10
CN1371243A (zh) 2002-09-25
CA2375943A1 (fr) 2001-01-25
CN1188031C (zh) 2005-02-09
WO2001005222A1 (fr) 2001-01-25
NZ516611A (en) 2003-09-26
AU780829B2 (en) 2005-04-21
EP1196027A1 (fr) 2002-04-17
IL147657A0 (en) 2002-08-14
RU2251838C2 (ru) 2005-05-20
KR20020092891A (ko) 2002-12-12
US6353152B1 (en) 2002-03-05

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