ZA200105491B - New morpholinobenzamide salts. - Google Patents
New morpholinobenzamide salts. Download PDFInfo
- Publication number
- ZA200105491B ZA200105491B ZA200105491A ZA200105491A ZA200105491B ZA 200105491 B ZA200105491 B ZA 200105491B ZA 200105491 A ZA200105491 A ZA 200105491A ZA 200105491 A ZA200105491 A ZA 200105491A ZA 200105491 B ZA200105491 B ZA 200105491B
- Authority
- ZA
- South Africa
- Prior art keywords
- salt
- disorders
- solvate
- treatment
- methylpiperazin
- Prior art date
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- HHAZUISNXJLXHR-UHFFFAOYSA-N 2-morpholin-4-ylbenzamide Chemical class NC(=O)C1=CC=CC=C1N1CCOCC1 HHAZUISNXJLXHR-UHFFFAOYSA-N 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 79
- 150000001875 compounds Chemical class 0.000 claims description 70
- 150000003839 salts Chemical class 0.000 claims description 67
- 239000012453 solvate Substances 0.000 claims description 45
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- 208000035475 disorder Diseases 0.000 claims description 26
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- IHDRUIHIJWCTIY-JOCHJYFZSA-N n-[(2r)-5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-morpholin-4-ylbenzamide Chemical compound C1CN(C)CCN1C1=CC=C(C)C2=C1C[C@H](NC(=O)C=1C=CC(=CC=1)N1CCOCC1)CC2 IHDRUIHIJWCTIY-JOCHJYFZSA-N 0.000 claims description 17
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- -1 (R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4- morpholinobenzamide hydrogen Chemical class 0.000 claims description 12
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- 208000024891 symptom Diseases 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 230000028016 temperature homeostasis Effects 0.000 description 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9900190A SE9900190D0 (sv) | 1999-01-22 | 1999-01-22 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105491B true ZA200105491B (en) | 2002-10-03 |
Family
ID=20414186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105491A ZA200105491B (en) | 1999-01-22 | 2001-07-03 | New morpholinobenzamide salts. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6291458B1 (zh) |
| EP (1) | EP1149083A1 (zh) |
| JP (1) | JP2002535320A (zh) |
| KR (1) | KR20010101585A (zh) |
| CN (1) | CN1188405C (zh) |
| AR (1) | AR030145A1 (zh) |
| AU (1) | AU778674B2 (zh) |
| BR (1) | BR0007577A (zh) |
| CA (1) | CA2359105A1 (zh) |
| CZ (1) | CZ20012643A3 (zh) |
| DZ (1) | DZ3002A1 (zh) |
| EE (1) | EE200100381A (zh) |
| HU (1) | HUP0200412A3 (zh) |
| ID (1) | ID30556A (zh) |
| IL (1) | IL144444A0 (zh) |
| IS (1) | IS6007A (zh) |
| MY (1) | MY133438A (zh) |
| NO (1) | NO20013601L (zh) |
| NZ (1) | NZ512684A (zh) |
| PL (1) | PL349775A1 (zh) |
| RU (1) | RU2237668C2 (zh) |
| SE (1) | SE9900190D0 (zh) |
| SK (1) | SK10222001A3 (zh) |
| TN (1) | TNSN00015A1 (zh) |
| TR (1) | TR200102087T2 (zh) |
| UA (1) | UA69438C2 (zh) |
| WO (1) | WO2000043378A1 (zh) |
| ZA (1) | ZA200105491B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0002729D0 (sv) * | 2000-07-20 | 2000-07-20 | Astrazeneca Ab | Novel compound form |
| AR055424A1 (es) | 2005-09-12 | 2007-08-22 | Wyeth Corp | Formulacion de liberacion sostenida y usos de la misma |
| GT200600416A (es) * | 2005-09-12 | 2007-09-20 | Sales salicilato y gentisato de un compuesto de piperazina | |
| GT200600414A (es) | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| US20080033050A1 (en) * | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
| RU2540464C2 (ru) * | 2012-05-28 | 2015-02-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации | Водорастворимое производное амида салициловой кислоты, обладающее транквилизирующей, ноотропной и анальгезирующей активностью |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3919624A1 (de) | 1989-06-15 | 1990-12-20 | Boehringer Ingelheim Kg | Neue 2,5-diaminotetraline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB9119932D0 (en) | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| GB9119920D0 (en) | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| PT533268E (pt) | 1991-09-18 | 2002-02-28 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d |
| DK148392D0 (da) | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
| GB2273930A (en) | 1992-12-30 | 1994-07-06 | Glaxo Group Ltd | Benzanilide derivatives |
| JP2810236B2 (ja) * | 1993-03-16 | 1998-10-15 | フアイザー・インコーポレイテツド | ナフタレン誘導体 |
| WO1995011243A1 (en) | 1993-10-19 | 1995-04-27 | Smithkline Beecham Plc | Benzanilide derivatives as 5ht-1d receptor antagonists |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| SE9702799D0 (sv) * | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
-
1999
- 1999-01-22 SE SE9900190A patent/SE9900190D0/xx unknown
-
2000
- 2000-01-09 DZ DZ000004A patent/DZ3002A1/xx active
- 2000-01-14 JP JP2000594794A patent/JP2002535320A/ja active Pending
- 2000-01-14 AU AU23374/00A patent/AU778674B2/en not_active Ceased
- 2000-01-14 SK SK1022-2001A patent/SK10222001A3/sk unknown
- 2000-01-14 TR TR2001/02087T patent/TR200102087T2/xx unknown
- 2000-01-14 ID IDW00200101578A patent/ID30556A/id unknown
- 2000-01-14 CA CA002359105A patent/CA2359105A1/en not_active Abandoned
- 2000-01-14 NZ NZ512684A patent/NZ512684A/xx unknown
- 2000-01-14 CN CNB008030103A patent/CN1188405C/zh not_active Expired - Fee Related
- 2000-01-14 WO PCT/SE2000/000079 patent/WO2000043378A1/en not_active Application Discontinuation
- 2000-01-14 EP EP00902246A patent/EP1149083A1/en not_active Withdrawn
- 2000-01-14 PL PL00349775A patent/PL349775A1/xx not_active Application Discontinuation
- 2000-01-14 CZ CZ20012643A patent/CZ20012643A3/cs unknown
- 2000-01-14 EE EEP200100381A patent/EE200100381A/xx unknown
- 2000-01-14 HU HU0200412A patent/HUP0200412A3/hu unknown
- 2000-01-14 RU RU2001123433A patent/RU2237668C2/ru not_active IP Right Cessation
- 2000-01-14 KR KR1020017009056A patent/KR20010101585A/ko not_active Application Discontinuation
- 2000-01-14 UA UA2001085896A patent/UA69438C2/uk unknown
- 2000-01-14 IL IL14444400A patent/IL144444A0/xx unknown
- 2000-01-14 BR BR0007577-9A patent/BR0007577A/pt not_active IP Right Cessation
- 2000-01-18 AR ARP000100215A patent/AR030145A1/es unknown
- 2000-01-20 MY MYPI20000180A patent/MY133438A/en unknown
- 2000-01-20 TN TNTNSN00015A patent/TNSN00015A1/fr unknown
- 2000-07-21 US US09/621,387 patent/US6291458B1/en not_active Expired - Fee Related
-
2001
- 2001-07-03 ZA ZA200105491A patent/ZA200105491B/en unknown
- 2001-07-17 IS IS6007A patent/IS6007A/is unknown
- 2001-07-20 NO NO20013601A patent/NO20013601L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SE9900190D0 (sv) | 1999-01-22 |
| WO2000043378A1 (en) | 2000-07-27 |
| HUP0200412A3 (en) | 2002-11-28 |
| IL144444A0 (en) | 2002-05-23 |
| HUP0200412A2 (en) | 2002-06-29 |
| PL349775A1 (en) | 2002-09-09 |
| NO20013601L (no) | 2001-09-11 |
| CZ20012643A3 (cs) | 2002-01-16 |
| TR200102087T2 (tr) | 2001-12-21 |
| AU2337400A (en) | 2000-08-07 |
| AR030145A1 (es) | 2003-08-13 |
| RU2237668C2 (ru) | 2004-10-10 |
| UA69438C2 (en) | 2004-09-15 |
| NZ512684A (en) | 2003-06-30 |
| KR20010101585A (ko) | 2001-11-14 |
| SK10222001A3 (sk) | 2002-03-05 |
| ID30556A (id) | 2001-12-20 |
| DZ3002A1 (fr) | 2004-03-27 |
| JP2002535320A (ja) | 2002-10-22 |
| AU778674B2 (en) | 2004-12-16 |
| NO20013601D0 (no) | 2001-07-20 |
| TNSN00015A1 (fr) | 2005-11-10 |
| US6291458B1 (en) | 2001-09-18 |
| MY133438A (en) | 2007-11-30 |
| IS6007A (is) | 2001-07-17 |
| CN1337956A (zh) | 2002-02-27 |
| CN1188405C (zh) | 2005-02-09 |
| CA2359105A1 (en) | 2000-07-27 |
| EE200100381A (et) | 2002-12-16 |
| EP1149083A1 (en) | 2001-10-31 |
| BR0007577A (pt) | 2001-10-23 |
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