ZA200104273B - New pharmaceutical formulation. - Google Patents
New pharmaceutical formulation. Download PDFInfo
- Publication number
- ZA200104273B ZA200104273B ZA200104273A ZA200104273A ZA200104273B ZA 200104273 B ZA200104273 B ZA 200104273B ZA 200104273 A ZA200104273 A ZA 200104273A ZA 200104273 A ZA200104273 A ZA 200104273A ZA 200104273 B ZA200104273 B ZA 200104273B
- Authority
- ZA
- South Africa
- Prior art keywords
- dosage form
- tablet
- pellets
- form according
- atpase inhibitor
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title description 3
- 239000002552 dosage form Substances 0.000 claims description 78
- 239000003826 tablet Substances 0.000 claims description 78
- 239000010410 layer Substances 0.000 claims description 72
- 239000008188 pellet Substances 0.000 claims description 70
- 230000002496 gastric effect Effects 0.000 claims description 60
- 150000003180 prostaglandins Chemical class 0.000 claims description 53
- 230000001262 anti-secretory effect Effects 0.000 claims description 52
- 238000009505 enteric coating Methods 0.000 claims description 42
- 239000002702 enteric coating Substances 0.000 claims description 42
- 239000000362 adenosine triphosphatase inhibitor Substances 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 35
- 229940121819 ATPase inhibitor Drugs 0.000 claims description 33
- 239000003814 drug Substances 0.000 claims description 33
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 32
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims description 28
- 229960005249 misoprostol Drugs 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 28
- 238000013265 extended release Methods 0.000 claims description 26
- 239000011159 matrix material Substances 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 24
- 229960000381 omeprazole Drugs 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 21
- 239000000480 calcium channel blocker Substances 0.000 claims description 18
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- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
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- 239000000969 carrier Substances 0.000 description 1
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- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
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- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
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- 238000011866 long-term treatment Methods 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical class [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 235000011160 magnesium carbonates Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
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- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
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- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229960004157 rabeprazole Drugs 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
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- 230000003248 secreting effect Effects 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9804314A SE9804314D0 (sv) | 1998-12-14 | 1998-12-14 | New pharmaceutical formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200104273B true ZA200104273B (en) | 2002-08-26 |
Family
ID=20413648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200104273A ZA200104273B (en) | 1998-12-14 | 2001-05-24 | New pharmaceutical formulation. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1150677A1 (fr) |
| JP (1) | JP2002532425A (fr) |
| KR (1) | KR20010093822A (fr) |
| CN (1) | CN1334731A (fr) |
| AU (1) | AU776079B2 (fr) |
| BR (1) | BR9916224A (fr) |
| CA (1) | CA2352613A1 (fr) |
| HK (1) | HK1041224A1 (fr) |
| IL (1) | IL143386A0 (fr) |
| NO (1) | NO20012915L (fr) |
| NZ (1) | NZ511999A (fr) |
| SE (1) | SE9804314D0 (fr) |
| WO (1) | WO2000035448A1 (fr) |
| ZA (1) | ZA200104273B (fr) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US7815937B2 (en) * | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
| US8268333B2 (en) | 2001-04-24 | 2012-09-18 | Lintec Corporation | Orally administered agent and an orally administered agent/supporting substrate complex |
| ITMI20020515A1 (it) * | 2002-03-12 | 2003-09-12 | Jagotec Ag | Sistema per il rilasco controllato di uno o piu' principi attivi |
| US8980322B2 (en) | 2003-03-17 | 2015-03-17 | Takeda Pharmaceutical Company Limited | Controlled release composition |
| US20060280794A1 (en) * | 2003-06-06 | 2006-12-14 | Naoru Hamaguchi | Solid pharmaceutical preparation |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| JP2005289867A (ja) * | 2004-03-31 | 2005-10-20 | Lintec Corp | 経口投与剤 |
| CN1311824C (zh) * | 2004-04-21 | 2007-04-25 | 常州市第四制药厂有限公司 | 奥美拉唑肠溶微粒制剂及制备方法 |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2602812C (fr) * | 2005-04-12 | 2014-11-18 | Sucampo Ag | Utilisation combinee d'un compose de prostaglandine et d'un inhibiteur de pompe a protons pour le traitement des troubles gastro-intestinaux |
| EP1987820A1 (fr) * | 2007-05-04 | 2008-11-05 | Christian Fiala, Ph. D. | Misoprostole à libération lente pour applications obstétriques et/ou gynécologiques |
| CN102078615A (zh) * | 2011-01-21 | 2011-06-01 | 北京华禧联合科技发展有限公司 | 质子泵抑制剂和胃黏膜保护剂组合物 |
| JP2017522321A (ja) * | 2014-07-17 | 2017-08-10 | ダウ グローバル テクノロジーズ エルエルシー | エチルセルロース分散系とフィルム |
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| EP3288556A4 (fr) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Compositions à désintégration par voie orale |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
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| KR20190122659A (ko) | 2017-01-04 | 2019-10-30 | 액섬 테라퓨틱스, 인크. | 멜록시캄을 포함하는 약학적 조성물 |
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-
1998
- 1998-12-14 SE SE9804314A patent/SE9804314D0/xx unknown
-
1999
- 1999-12-10 CA CA002352613A patent/CA2352613A1/fr not_active Abandoned
- 1999-12-10 EP EP99963820A patent/EP1150677A1/fr not_active Withdrawn
- 1999-12-10 CN CN99816118A patent/CN1334731A/zh active Pending
- 1999-12-10 IL IL14338699A patent/IL143386A0/xx unknown
- 1999-12-10 WO PCT/SE1999/002315 patent/WO2000035448A1/fr not_active Application Discontinuation
- 1999-12-10 AU AU20186/00A patent/AU776079B2/en not_active Ceased
- 1999-12-10 KR KR1020017007344A patent/KR20010093822A/ko not_active Application Discontinuation
- 1999-12-10 NZ NZ511999A patent/NZ511999A/xx unknown
- 1999-12-10 JP JP2000587768A patent/JP2002532425A/ja active Pending
- 1999-12-10 BR BR9916224-5A patent/BR9916224A/pt not_active IP Right Cessation
-
2001
- 2001-05-24 ZA ZA200104273A patent/ZA200104273B/en unknown
- 2001-06-13 NO NO20012915A patent/NO20012915L/no not_active Application Discontinuation
-
2002
- 2002-04-22 HK HK02103023.3A patent/HK1041224A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1150677A1 (fr) | 2001-11-07 |
| WO2000035448A1 (fr) | 2000-06-22 |
| NO20012915D0 (no) | 2001-06-13 |
| CA2352613A1 (fr) | 2000-06-22 |
| JP2002532425A (ja) | 2002-10-02 |
| AU2018600A (en) | 2000-07-03 |
| NO20012915L (no) | 2001-08-13 |
| BR9916224A (pt) | 2001-09-04 |
| SE9804314D0 (sv) | 1998-12-14 |
| AU776079B2 (en) | 2004-08-26 |
| CN1334731A (zh) | 2002-02-06 |
| NZ511999A (en) | 2002-10-25 |
| KR20010093822A (ko) | 2001-10-29 |
| IL143386A0 (en) | 2002-11-10 |
| HK1041224A1 (zh) | 2002-07-05 |
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