ZA200102233B - Chemotherapy of cancer with acetyldinaline in combination with Gemcitabine, Capecitabine or Cisplatin. - Google Patents

Chemotherapy of cancer with acetyldinaline in combination with Gemcitabine, Capecitabine or Cisplatin. Download PDF

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Publication number
ZA200102233B
ZA200102233B ZA200102233A ZA200102233A ZA200102233B ZA 200102233 B ZA200102233 B ZA 200102233B ZA 200102233 A ZA200102233 A ZA 200102233A ZA 200102233 A ZA200102233 A ZA 200102233A ZA 200102233 B ZA200102233 B ZA 200102233B
Authority
ZA
South Africa
Prior art keywords
combination
acetyldinaline
gemcitabine
substance
composition
Prior art date
Application number
ZA200102233A
Other languages
English (en)
Inventor
William Richard Grove
Wayne Daniel Klohs
Ronald Lynn Merriman
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ZA200102233B publication Critical patent/ZA200102233B/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
ZA200102233A 1998-09-25 2001-03-16 Chemotherapy of cancer with acetyldinaline in combination with Gemcitabine, Capecitabine or Cisplatin. ZA200102233B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10180998P 1998-09-25 1998-09-25

Publications (1)

Publication Number Publication Date
ZA200102233B true ZA200102233B (en) 2002-06-18

Family

ID=22286531

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200102233A ZA200102233B (en) 1998-09-25 2001-03-16 Chemotherapy of cancer with acetyldinaline in combination with Gemcitabine, Capecitabine or Cisplatin.

Country Status (34)

Country Link
US (3) US6469058B1 (tr)
EP (1) EP1115391B1 (tr)
JP (1) JP2002525320A (tr)
KR (1) KR20010075348A (tr)
CN (1) CN1319009A (tr)
AP (1) AP2001002109A0 (tr)
AT (1) ATE225655T1 (tr)
AU (1) AU762079B2 (tr)
BG (1) BG105470A (tr)
BR (1) BR9913952A (tr)
CA (1) CA2342981A1 (tr)
CZ (1) CZ2001905A3 (tr)
DE (1) DE69903458T2 (tr)
DK (1) DK1115391T3 (tr)
EA (1) EA200100369A1 (tr)
EE (1) EE200100187A (tr)
ES (1) ES2185378T3 (tr)
GE (1) GEP20043199B (tr)
HK (1) HK1040190A1 (tr)
HR (1) HRP20010225B1 (tr)
HU (1) HUP0103640A3 (tr)
ID (1) ID30046A (tr)
IL (1) IL141951A0 (tr)
IS (1) IS5888A (tr)
NO (1) NO20011493L (tr)
NZ (1) NZ510504A (tr)
OA (1) OA11659A (tr)
PL (1) PL348673A1 (tr)
PT (1) PT1115391E (tr)
SK (1) SK3602001A3 (tr)
TR (1) TR200100859T2 (tr)
WO (1) WO2000018393A1 (tr)
YU (1) YU22401A (tr)
ZA (1) ZA200102233B (tr)

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CZ20022216A3 (cs) * 2001-07-02 2003-05-14 Warner-Lambert Company Kombinační chemoterapie
CA2383259A1 (en) 2002-04-23 2003-10-23 Celator Technologies Inc. Synergistic compositions
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US7456219B2 (en) * 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
RU2320331C2 (ru) * 2002-03-04 2008-03-27 МЕРК ЭйчДиЭйСи Рисерч, ЛЛС. Способ индукции конечной дифференцировки
US20040132825A1 (en) * 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
US20040018968A1 (en) * 2002-04-15 2004-01-29 George Sgouros Use of histone deacetylase inhibitors in combination with radiation for the treatment of cancer
US8026216B2 (en) 2002-10-24 2011-09-27 Spectrum Pharmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
US20070032422A1 (en) 2002-10-24 2007-02-08 Spectrum Pharmaceuticals, Inc. Methods, compositions and articles of manufacture for contributing to the treatment of cancers
GB0226434D0 (en) * 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
WO2004045617A1 (en) * 2002-11-15 2004-06-03 Warner-Lambert Company Llc Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer
US20060165744A1 (en) * 2003-05-22 2006-07-27 Neopharm, Inc Combination liposomal formulations
PE20050206A1 (es) * 2003-05-26 2005-03-26 Schering Ag Composicion farmaceutica que contiene un inhibidor de histona deacetilasa
CN100431606C (zh) * 2004-11-22 2008-11-12 山东蓝金生物工程有限公司 一种抗癌药物组合物
US7957507B2 (en) 2005-02-28 2011-06-07 Cadman Patrick F Method and apparatus for modulating a radiation beam
CN100443081C (zh) * 2005-04-05 2008-12-17 吴一心 木犀草素与一种铂类化疗药物联合用于制备抗肿瘤的药物
US8232535B2 (en) 2005-05-10 2012-07-31 Tomotherapy Incorporated System and method of treating a patient with radiation therapy
US7839972B2 (en) 2005-07-22 2010-11-23 Tomotherapy Incorporated System and method of evaluating dose delivered by a radiation therapy system
ATE507879T1 (de) 2005-07-22 2011-05-15 Tomotherapy Inc System zur verabreichung einer strahlentherapie auf ein sich bewegendes zielgebiet
WO2007014106A2 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated System and method of delivering radiation therapy to a moving region of interest
EP1907981A4 (en) * 2005-07-22 2009-10-21 Tomotherapy Inc METHOD AND SYSTEM FOR DOSE EVALUATION ADMINISTERED
JP2009502255A (ja) * 2005-07-22 2009-01-29 トモセラピー・インコーポレーテッド 治療プランのデリバリにおける品質保証基準を評価するための方法およびシステム
US8442287B2 (en) 2005-07-22 2013-05-14 Tomotherapy Incorporated Method and system for evaluating quality assurance criteria in delivery of a treatment plan
KR20080044250A (ko) 2005-07-23 2008-05-20 토모테라피 인코포레이티드 갠트리 및 진료대의 조합된 움직임을 이용하는 방사선치료의 영상화 및 시행
DK2059254T3 (en) 2006-08-31 2015-07-13 Spectrum Pharmaceuticals Inc Sensitization of tumor cells to radiation therapy by administration of endothelin agonists
WO2009096245A1 (ja) * 2008-01-28 2009-08-06 Nanocarrier Co., Ltd. 医薬組成物又は組合せ剤
FR2937867B1 (fr) * 2008-11-03 2011-03-04 Biorebus Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs.
US8324180B2 (en) 2009-04-06 2012-12-04 Eisai Inc. Compositions and methods for treating cancer
US8729130B2 (en) 2011-07-01 2014-05-20 The Broad Institute, Inc. Methods of using novel solid forms of tacedinaline
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US9308235B2 (en) 2012-05-09 2016-04-12 Spectrum Pharmaceuticals, Inc. Treatment of primary and metastatic carcinoma
EP2711007A1 (en) 2012-09-19 2014-03-26 Institut Univ. de Ciència i Tecnologia, S.A. 4-Aminopyrazolo[3,4-d]pyrimidine for use in treating or preventing primary and metastatic breast and prostate cancer
EP2711008A1 (en) 2012-09-19 2014-03-26 Institut Univ. de Ciència i Tecnologia, S.A. N6,N6-dimethyladenosine for use in treating or preventing primary and metastatic breast cancer
EP2711009A1 (en) 2012-09-19 2014-03-26 Institut Univ. de Ciència i Tecnologia, S.A. Compounds for use in treating or preventing primary and metastatic breast and prostate cancer
US9443633B2 (en) 2013-02-26 2016-09-13 Accuray Incorporated Electromagnetically actuated multi-leaf collimator
US10189797B2 (en) 2015-12-30 2019-01-29 Duke University Chemical modulators of immune checkpoints and therapeutic use

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NZ219974A (en) * 1986-04-22 1989-08-29 Goedecke Ag N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
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US5972986A (en) * 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
KR20010075348A (ko) * 1998-09-25 2001-08-09 로즈 암스트롱, 크리스틴 에이. 트러트웨인 아세틸디날린과 겜시타빈, 카페시타빈 또는 시스플라틴을함께 사용하는 항암 화학요법

Also Published As

Publication number Publication date
AP2001002109A0 (en) 2001-03-31
TR200100859T2 (tr) 2001-08-21
HRP20010225B1 (en) 2004-10-31
WO2000018393A1 (en) 2000-04-06
PL348673A1 (en) 2002-06-03
ATE225655T1 (de) 2002-10-15
EP1115391B1 (en) 2002-10-09
US20030086965A1 (en) 2003-05-08
NO20011493D0 (no) 2001-03-23
BR9913952A (pt) 2001-06-12
ES2185378T3 (es) 2003-04-16
HUP0103640A3 (en) 2003-01-28
IL141951A0 (en) 2002-03-10
HUP0103640A2 (en) 2002-06-29
CA2342981A1 (en) 2000-04-06
AU5092199A (en) 2000-04-17
EA200100369A1 (ru) 2001-10-22
DK1115391T3 (da) 2003-02-10
HRP20010225A2 (en) 2002-04-30
DE69903458T2 (de) 2003-07-10
HK1040190A1 (zh) 2002-05-31
BG105470A (en) 2001-12-29
AU762079B2 (en) 2003-06-19
CN1319009A (zh) 2001-10-24
SK3602001A3 (en) 2002-07-02
OA11659A (en) 2004-12-08
CZ2001905A3 (cs) 2001-08-15
JP2002525320A (ja) 2002-08-13
NO20011493L (no) 2001-05-23
IS5888A (is) 2001-03-14
US6469058B1 (en) 2002-10-22
DE69903458D1 (de) 2002-11-14
EE200100187A (et) 2002-08-15
GEP20043199B (en) 2004-03-25
YU22401A (sh) 2004-03-12
PT1115391E (pt) 2003-02-28
EP1115391A1 (en) 2001-07-18
US20030170300A1 (en) 2003-09-11
NZ510504A (en) 2003-09-26
KR20010075348A (ko) 2001-08-09
ID30046A (id) 2001-11-01

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