ZA200100939B - Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody. - Google Patents
Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody. Download PDFInfo
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- ZA200100939B ZA200100939B ZA200100939A ZA200100939A ZA200100939B ZA 200100939 B ZA200100939 B ZA 200100939B ZA 200100939 A ZA200100939 A ZA 200100939A ZA 200100939 A ZA200100939 A ZA 200100939A ZA 200100939 B ZA200100939 B ZA 200100939B
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- humanized
- immunoglobulin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/136,315 US6228360B1 (en) | 1998-08-19 | 1998-08-19 | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200100939B true ZA200100939B (en) | 2001-09-03 |
Family
ID=22472317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200100939A ZA200100939B (en) | 1998-08-19 | 2001-02-02 | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody. |
Country Status (17)
Country | Link |
---|---|
US (4) | US6228360B1 (ja) |
EP (1) | EP1112085B1 (ja) |
JP (1) | JP4590734B2 (ja) |
KR (1) | KR100693260B1 (ja) |
CN (1) | CN1259972C (ja) |
AT (1) | ATE476989T1 (ja) |
AU (1) | AU766500B2 (ja) |
BR (1) | BR9913084A (ja) |
CA (1) | CA2340466A1 (ja) |
DE (1) | DE69942668D1 (ja) |
HU (1) | HUP0103573A3 (ja) |
IL (2) | IL141158A0 (ja) |
NO (1) | NO20010747L (ja) |
NZ (1) | NZ509536A (ja) |
RU (1) | RU2223785C2 (ja) |
WO (1) | WO2000010601A1 (ja) |
ZA (1) | ZA200100939B (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6228360B1 (en) | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
GB0031448D0 (en) * | 2000-12-22 | 2001-02-07 | Leuven K U Res & Dev | Inhibition of the vWF-collagen interaction by anti-human vWF monoclonal antibody (82D6A3) results in abolition of in vivo arterial platelet thrombus formation |
AU2002335815A1 (en) * | 2001-10-16 | 2003-04-28 | Rxkinetix, Inc. | High-concentration protein formulations and method of manufacture |
JP2005298336A (ja) * | 2002-01-29 | 2005-10-27 | Ajinomoto Co Inc | 炎症性疾患治療用薬剤 |
WO2004011030A1 (ja) * | 2002-07-29 | 2004-02-05 | Ajinomoto Co., Inc. | 血小板減少症治療用医薬組成物 |
ATE512364T1 (de) * | 2002-08-07 | 2011-06-15 | Ablynx Nv | Modulation der blutplättchen-adhäsion basierend auf dem oberflächen-exponierten beta-switch loop des blutplättchen-glycoproteins ib-alpha |
EP1587838B1 (en) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
CA2559280A1 (en) * | 2004-03-15 | 2005-09-29 | Biogen Idec Ma Inc. | Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing |
EP1755642B1 (en) * | 2004-04-15 | 2010-01-13 | Athera Biotechnologies Ab | Annexin v for preventing plaque rupture |
CA2579374A1 (en) * | 2004-09-07 | 2006-03-30 | Archemix Corp. | Aptamers to von willebrand factor and their use as thrombotic disease therapeutics |
US20090202986A1 (en) * | 2004-10-22 | 2009-08-13 | Huse William D | Methods of optimizing antibody variable region binding affinity |
WO2006074947A2 (en) * | 2005-01-14 | 2006-07-20 | Ablynx N.V. | METHODS AND ASSAYS FOR DISTINGUISHING BETWEEN DIFFERENT FORMS OF DISEASES AND DISORDERS CHARACTERIZED BY THROMBOCYTOPENIA AND/OR BY SPONTANEOUS INTERACTION BETWEEN VON WILLEBRAND FACTOR (vWF) AND PLATELETS |
KR101414438B1 (ko) * | 2005-05-20 | 2014-07-10 | 아블린쓰 엔.브이. | 폰 빌레브란트 인자에 대한 단일 도메인 vhh 항체 |
AR070141A1 (es) * | 2008-01-23 | 2010-03-17 | Glenmark Pharmaceuticals Sa | Anticuerpos humanizados especificos para el factor von willebrand |
JP2011518772A (ja) * | 2008-03-21 | 2011-06-30 | アブリンクス エン.ヴェー. | フォンウィルブランド因子特異的結合因子及びこれらに関する使用方法 |
US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
WO2010091231A1 (en) * | 2009-02-06 | 2010-08-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN102532316B (zh) * | 2010-12-24 | 2014-06-18 | 神州细胞工程有限公司 | 一种抗vWF单克隆抗体及其应用 |
WO2015158851A1 (en) * | 2014-04-16 | 2015-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies for the prevention or the treatment of bleeding episodes |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB9020282D0 (en) * | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
DE69233482T2 (de) * | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
US5777085A (en) * | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
ZA93779B (en) * | 1992-02-06 | 1993-08-05 | Schering Corp | Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5. |
EP0625200B1 (en) * | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
ATE236993T1 (de) * | 1994-11-30 | 2003-04-15 | Ajinomoto Kk | Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper |
US6228360B1 (en) * | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
-
1998
- 1998-08-19 US US09/136,315 patent/US6228360B1/en not_active Expired - Lifetime
-
1999
- 1999-08-19 HU HU0103573A patent/HUP0103573A3/hu unknown
- 1999-08-19 DE DE69942668T patent/DE69942668D1/de not_active Expired - Lifetime
- 1999-08-19 AU AU56680/99A patent/AU766500B2/en not_active Ceased
- 1999-08-19 RU RU2001107136/15A patent/RU2223785C2/ru not_active IP Right Cessation
- 1999-08-19 IL IL14115899A patent/IL141158A0/xx active IP Right Grant
- 1999-08-19 AT AT99943621T patent/ATE476989T1/de active
- 1999-08-19 JP JP2000565921A patent/JP4590734B2/ja not_active Expired - Fee Related
- 1999-08-19 BR BR9913084-0A patent/BR9913084A/pt not_active Application Discontinuation
- 1999-08-19 WO PCT/US1999/016724 patent/WO2000010601A1/en active IP Right Grant
- 1999-08-19 CA CA002340466A patent/CA2340466A1/en not_active Abandoned
- 1999-08-19 NZ NZ509536A patent/NZ509536A/xx unknown
- 1999-08-19 EP EP99943621A patent/EP1112085B1/en not_active Expired - Lifetime
- 1999-08-19 CN CNB998092223A patent/CN1259972C/zh not_active Expired - Fee Related
- 1999-08-19 KR KR1020017002074A patent/KR100693260B1/ko not_active IP Right Cessation
-
2001
- 2001-01-24 US US09/767,888 patent/US6613328B2/en not_active Expired - Lifetime
- 2001-01-29 IL IL141158A patent/IL141158A/en not_active IP Right Cessation
- 2001-02-02 ZA ZA200100939A patent/ZA200100939B/en unknown
- 2001-02-14 NO NO20010747A patent/NO20010747L/no unknown
-
2002
- 2002-11-07 US US10/289,181 patent/US7138116B2/en not_active Expired - Fee Related
-
2005
- 2005-02-28 US US11/066,262 patent/US7311913B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
RU2223785C2 (ru) | 2004-02-20 |
AU766500B2 (en) | 2003-10-16 |
EP1112085A4 (en) | 2002-11-20 |
KR100693260B1 (ko) | 2007-03-13 |
US20030180293A1 (en) | 2003-09-25 |
US20030064068A1 (en) | 2003-04-03 |
DE69942668D1 (de) | 2010-09-23 |
JP2002523379A (ja) | 2002-07-30 |
HUP0103573A2 (hu) | 2002-01-28 |
BR9913084A (pt) | 2001-05-08 |
KR20010072749A (ko) | 2001-07-31 |
US6613328B2 (en) | 2003-09-02 |
CN1259972C (zh) | 2006-06-21 |
NO20010747D0 (no) | 2001-02-14 |
JP4590734B2 (ja) | 2010-12-01 |
HUP0103573A3 (en) | 2003-09-29 |
IL141158A (en) | 2006-04-10 |
AU5668099A (en) | 2000-03-14 |
NZ509536A (en) | 2002-11-26 |
EP1112085A1 (en) | 2001-07-04 |
CN1311691A (zh) | 2001-09-05 |
CA2340466A1 (en) | 2000-03-02 |
US6228360B1 (en) | 2001-05-08 |
IL141158A0 (en) | 2002-02-10 |
NO20010747L (no) | 2001-04-03 |
US7138116B2 (en) | 2006-11-21 |
US7311913B2 (en) | 2007-12-25 |
US20050197494A1 (en) | 2005-09-08 |
ATE476989T1 (de) | 2010-08-15 |
WO2000010601A1 (en) | 2000-03-02 |
EP1112085B1 (en) | 2010-08-11 |
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