ZA200100902B - Tricyclic carboxamides. - Google Patents
Tricyclic carboxamides. Download PDFInfo
- Publication number
- ZA200100902B ZA200100902B ZA200100902A ZA200100902A ZA200100902B ZA 200100902 B ZA200100902 B ZA 200100902B ZA 200100902 A ZA200100902 A ZA 200100902A ZA 200100902 A ZA200100902 A ZA 200100902A ZA 200100902 B ZA200100902 B ZA 200100902B
- Authority
- ZA
- South Africa
- Prior art keywords
- hexahydropyrrolo
- isoquinolin
- acetyl
- benzamide
- methoxy
- Prior art date
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- 150000003857 carboxamides Chemical class 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 74
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- -1 CFs Chemical group 0.000 claims description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 20
- 201000006417 multiple sclerosis Diseases 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
- 208000035475 disorder Diseases 0.000 claims description 18
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 16
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 16
- 230000001537 neural effect Effects 0.000 claims description 16
- 208000004296 neuralgia Diseases 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 239000012453 solvate Substances 0.000 claims description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims description 10
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- 150000001408 amides Chemical class 0.000 claims description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 3
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- RBIZQDIIVYJNRS-UHFFFAOYSA-N 1,3-benzothiazole-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2SC=NC2=C1 RBIZQDIIVYJNRS-UHFFFAOYSA-N 0.000 claims description 2
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- UOBYKYZJUGYBDK-UHFFFAOYSA-N 2-naphthoic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CC=C21 UOBYKYZJUGYBDK-UHFFFAOYSA-N 0.000 claims description 2
- GUCPYIYFQVTFSI-UHFFFAOYSA-N 4-methoxybenzamide Chemical compound COC1=CC=C(C(N)=O)C=C1 GUCPYIYFQVTFSI-UHFFFAOYSA-N 0.000 claims description 2
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- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 2
- BLWCIEOODBBGSC-UHFFFAOYSA-N n-(1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-9-yl)-3-cyano-4-methoxybenzamide Chemical compound C1=C(C#N)C(OC)=CC=C1C(=O)NC1=CC=C(CCN2C3CCC2)C3=C1 BLWCIEOODBBGSC-UHFFFAOYSA-N 0.000 claims description 2
- BWTLYNFUBHGSQG-UHFFFAOYSA-N n-(1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-9-yl)-3-cyano-4-propan-2-yloxybenzamide Chemical compound C1=C(C#N)C(OC(C)C)=CC=C1C(=O)NC1=CC=C(CCN2C3CCC2)C3=C1 BWTLYNFUBHGSQG-UHFFFAOYSA-N 0.000 claims description 2
- HUIGNBYSACWHQP-UHFFFAOYSA-N n-(1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-9-yl)-4-ethoxy-3-fluorobenzamide Chemical compound C1=C(F)C(OCC)=CC=C1C(=O)NC1=CC=C(CCN2C3CCC2)C3=C1 HUIGNBYSACWHQP-UHFFFAOYSA-N 0.000 claims description 2
- MHCZRCOSDFLVMX-UHFFFAOYSA-N n-(1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-9-yl)-4-methoxy-3-(trifluoromethyl)benzamide Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1C(=O)NC1=CC=C(CCN2C3CCC2)C3=C1 MHCZRCOSDFLVMX-UHFFFAOYSA-N 0.000 claims description 2
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- JYUDYBYKNXSZPX-UHFFFAOYSA-N 3-acetyl-n-(2,3,5,6,7,11b-hexahydro-1h-pyrrolo[2,1-a][2]benzazepin-10-yl)-4-propan-2-yloxybenzamide Chemical compound C1=C(C(C)=O)C(OC(C)C)=CC=C1C(=O)NC1=CC=C(CCCN2C3CCC2)C3=C1 JYUDYBYKNXSZPX-UHFFFAOYSA-N 0.000 claims 1
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- CFZRSQWRMQKGJA-UHFFFAOYSA-N n-(1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-9-yl)-3-chloro-4-ethoxybenzamide Chemical compound C1=C(Cl)C(OCC)=CC=C1C(=O)NC1=CC=C(CCN2C3CCC2)C3=C1 CFZRSQWRMQKGJA-UHFFFAOYSA-N 0.000 claims 1
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- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9817028.5A GB9817028D0 (en) | 1998-08-05 | 1998-08-05 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200100902B true ZA200100902B (en) | 2002-05-14 |
Family
ID=10836742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200100902A ZA200100902B (en) | 1998-08-05 | 2001-02-01 | Tricyclic carboxamides. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1102769B1 (hu) |
| JP (1) | JP2002522436A (hu) |
| KR (1) | KR20010072262A (hu) |
| CN (1) | CN1324359A (hu) |
| AR (1) | AR020002A1 (hu) |
| AT (1) | ATE237615T1 (hu) |
| AU (1) | AU754638B2 (hu) |
| BR (1) | BR9912707A (hu) |
| CA (1) | CA2339362A1 (hu) |
| CO (1) | CO5080783A1 (hu) |
| CZ (1) | CZ293667B6 (hu) |
| DE (1) | DE69906985T2 (hu) |
| DK (1) | DK1102769T3 (hu) |
| ES (1) | ES2197665T3 (hu) |
| GB (1) | GB9817028D0 (hu) |
| HK (1) | HK1037919A1 (hu) |
| HU (1) | HUP0103311A3 (hu) |
| IL (1) | IL141164A0 (hu) |
| NO (1) | NO20010584D0 (hu) |
| NZ (1) | NZ509685A (hu) |
| PL (1) | PL346167A1 (hu) |
| PT (1) | PT1102769E (hu) |
| TR (1) | TR200100364T2 (hu) |
| TW (1) | TW518334B (hu) |
| WO (1) | WO2000008020A2 (hu) |
| ZA (1) | ZA200100902B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| IN2015DN01662A (hu) | 2012-09-18 | 2015-07-03 | Auspex Pharmaceuticals Inc | |
| WO2015077521A1 (en) * | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| EA201791466A1 (ru) | 2013-12-03 | 2017-11-30 | Оспекс Фармасьютикалз, Инк. | Способы получения соединений бензохинолина |
| PL3265085T3 (pl) | 2015-03-06 | 2022-11-07 | Auspex Pharmaceuticals, Inc. | Sposoby leczenia zaburzeń związanych z nieprawidłowymi ruchami mimowolnymi |
| CN108912118A (zh) * | 2018-07-12 | 2018-11-30 | 新乡学院 | 一种四氢异喹啉并三嗪骨架化合物及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0067565A1 (en) * | 1981-06-16 | 1982-12-22 | Beecham Group Plc | Pharmaceutically active compounds |
-
1998
- 1998-08-05 GB GBGB9817028.5A patent/GB9817028D0/en not_active Ceased
-
1999
- 1999-08-03 IL IL14116499A patent/IL141164A0/xx unknown
- 1999-08-03 PL PL99346167A patent/PL346167A1/xx not_active Application Discontinuation
- 1999-08-03 AU AU55098/99A patent/AU754638B2/en not_active Ceased
- 1999-08-03 JP JP2000563653A patent/JP2002522436A/ja active Pending
- 1999-08-03 DE DE69906985T patent/DE69906985T2/de not_active Expired - Fee Related
- 1999-08-03 DK DK99941505T patent/DK1102769T3/da active
- 1999-08-03 WO PCT/EP1999/005584 patent/WO2000008020A2/en not_active Application Discontinuation
- 1999-08-03 EP EP99941505A patent/EP1102769B1/en not_active Expired - Lifetime
- 1999-08-03 ES ES99941505T patent/ES2197665T3/es not_active Expired - Lifetime
- 1999-08-03 KR KR1020017001531A patent/KR20010072262A/ko not_active Application Discontinuation
- 1999-08-03 HU HU0103311A patent/HUP0103311A3/hu unknown
- 1999-08-03 CN CN99811645A patent/CN1324359A/zh active Pending
- 1999-08-03 AT AT99941505T patent/ATE237615T1/de not_active IP Right Cessation
- 1999-08-03 CZ CZ2001436A patent/CZ293667B6/cs not_active IP Right Cessation
- 1999-08-03 PT PT99941505T patent/PT1102769E/pt unknown
- 1999-08-03 BR BR9912707-5A patent/BR9912707A/pt not_active IP Right Cessation
- 1999-08-03 NZ NZ509685A patent/NZ509685A/en unknown
- 1999-08-03 CA CA002339362A patent/CA2339362A1/en not_active Abandoned
- 1999-08-03 TR TR2001/00364T patent/TR200100364T2/xx unknown
- 1999-08-04 CO CO99049308A patent/CO5080783A1/es unknown
- 1999-08-04 AR ARP990103876A patent/AR020002A1/es not_active Application Discontinuation
- 1999-08-27 TW TW088114673A patent/TW518334B/zh not_active IP Right Cessation
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2001
- 2001-02-01 ZA ZA200100902A patent/ZA200100902B/en unknown
- 2001-02-02 NO NO20010584A patent/NO20010584D0/no not_active Application Discontinuation
- 2001-11-08 HK HK01107868A patent/HK1037919A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002522436A (ja) | 2002-07-23 |
| AU5509899A (en) | 2000-02-28 |
| WO2000008020A3 (en) | 2000-07-13 |
| PL346167A1 (en) | 2002-01-28 |
| TW518334B (en) | 2003-01-21 |
| GB9817028D0 (en) | 1998-09-30 |
| EP1102769A2 (en) | 2001-05-30 |
| ATE237615T1 (de) | 2003-05-15 |
| TR200100364T2 (tr) | 2001-09-21 |
| CN1324359A (zh) | 2001-11-28 |
| HUP0103311A3 (en) | 2002-10-28 |
| NO20010584L (no) | 2001-02-02 |
| KR20010072262A (ko) | 2001-07-31 |
| PT1102769E (pt) | 2003-08-29 |
| BR9912707A (pt) | 2001-11-06 |
| DE69906985T2 (de) | 2004-02-12 |
| NO20010584D0 (no) | 2001-02-02 |
| HUP0103311A2 (hu) | 2002-02-28 |
| CZ2001436A3 (cs) | 2001-08-15 |
| CA2339362A1 (en) | 2000-02-17 |
| NZ509685A (en) | 2003-07-25 |
| DE69906985D1 (en) | 2003-05-22 |
| DK1102769T3 (da) | 2003-08-11 |
| HK1037919A1 (en) | 2002-02-22 |
| AU754638B2 (en) | 2002-11-21 |
| AR020002A1 (es) | 2002-03-27 |
| WO2000008020A8 (en) | 2001-04-26 |
| CO5080783A1 (es) | 2001-09-25 |
| EP1102769B1 (en) | 2003-04-16 |
| IL141164A0 (en) | 2002-11-10 |
| WO2000008020A2 (en) | 2000-02-17 |
| ES2197665T3 (es) | 2004-01-01 |
| CZ293667B6 (cs) | 2004-06-16 |
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