YU81000A - Derivati 2-(purin-9-il)-tetrahidrofuran-3,4 diola - Google Patents
Derivati 2-(purin-9-il)-tetrahidrofuran-3,4 diolaInfo
- Publication number
- YU81000A YU81000A YU81000A YU81000A YU81000A YU 81000 A YU81000 A YU 81000A YU 81000 A YU81000 A YU 81000A YU 81000 A YU81000 A YU 81000A YU 81000 A YU81000 A YU 81000A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- purin
- tetrahydrofuran
- diol derivatives
- diol
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
U skladu sa ovim pronalaskom daju se nova jedinjenja formule (I) u kojoj su R1, R2, R3, Z1, Z2, Z3 i Z4 definisani u opisu ove prijave, postupci za njihovo dobijanje i njihova upotreba u postupku dobijanja leka za tretiranje inflamatornih bolesti.[There are provided according to the invention novel compounds of formula (I), wherein R1, R2, R3, Z1, Z2, Z3 and Z4 are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9813565.0A GB9813565D0 (en) | 1998-06-23 | 1998-06-23 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
YU81000A true YU81000A (sh) | 2003-10-31 |
Family
ID=10834254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU81000A YU81000A (sh) | 1998-06-23 | 1999-06-23 | Derivati 2-(purin-9-il)-tetrahidrofuran-3,4 diola |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1090023B1 (sh) |
JP (1) | JP2002518511A (sh) |
KR (1) | KR20010071570A (sh) |
CN (1) | CN1313860A (sh) |
AP (1) | AP2000002013A0 (sh) |
AT (1) | ATE249474T1 (sh) |
AU (1) | AU758979B2 (sh) |
BR (1) | BR9911488A (sh) |
CA (1) | CA2335758A1 (sh) |
DE (1) | DE69911207D1 (sh) |
EA (1) | EA200001223A1 (sh) |
EE (1) | EE200000764A (sh) |
GB (1) | GB9813565D0 (sh) |
HR (1) | HRP20000895A2 (sh) |
HU (1) | HUP0102454A3 (sh) |
ID (1) | ID28219A (sh) |
IL (1) | IL140285A0 (sh) |
IS (1) | IS5774A (sh) |
NO (1) | NO20006521L (sh) |
NZ (1) | NZ508918A (sh) |
PL (1) | PL345097A1 (sh) |
SK (1) | SK19532000A3 (sh) |
TR (1) | TR200100411T2 (sh) |
WO (1) | WO1999067264A1 (sh) |
YU (1) | YU81000A (sh) |
ZA (1) | ZA200007515B (sh) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
US7427606B2 (en) | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7214665B2 (en) | 2001-10-01 | 2007-05-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
GB0104555D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New Therapeutic method |
AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
WO2006028618A1 (en) | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
NZ553288A (en) | 2004-08-02 | 2010-12-24 | Univ Virginia | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
KR20080049113A (ko) | 2005-10-21 | 2008-06-03 | 노파르티스 아게 | Il-13에 대항한 인간 항체 및 치료적 용도 |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
ATE502943T1 (de) | 2006-09-29 | 2011-04-15 | Novartis Ag | Pyrazolopyrimidine als pi3k-lipidkinasehemmer |
EP2089393A1 (en) | 2006-10-30 | 2009-08-19 | Novartis AG | Heterocyclic compounds as antiinflammatory agents |
JP5584138B2 (ja) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
JP2012516345A (ja) | 2009-01-29 | 2012-07-19 | ノバルティス アーゲー | 星細胞腫治療用置換ベンゾイミダゾール |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
AU2010283806A1 (en) | 2009-08-12 | 2012-03-01 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
ES2709108T3 (es) | 2009-08-17 | 2019-04-15 | Intellikine Llc | Compuestos heterocíclicos y usos de los mismos |
AU2010284972A1 (en) | 2009-08-20 | 2012-03-08 | Novartis Ag | Heterocyclic oxime compounds |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
EP2673277A1 (en) | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
BR112014006223A8 (pt) | 2011-09-15 | 2018-01-09 | Novartis Ag | 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação |
JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン, エルエルシー | Mtor阻害剤を使用する強化された治療レジメン |
CN104245701A (zh) | 2012-04-03 | 2014-12-24 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
EP2968340A4 (en) | 2013-03-15 | 2016-08-10 | Intellikine Llc | COMBINING KINASE INHIBITORS AND USES THEREOF |
WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
MX2017001461A (es) | 2014-07-31 | 2017-05-11 | Novartis Ag | Terapia de combinacion. |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
WO1998001459A1 (en) * | 1996-07-05 | 1998-01-15 | Novo Nordisk A/S | Novel n-alkoxyadenine derivatives acting as cytokine inhibitors |
TW528755B (en) * | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
YU44900A (sh) * | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
AR017457A1 (es) * | 1998-02-14 | 2001-09-05 | Glaxo Group Ltd | Compuestos derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol, procesos para su preparacion, composiciones que los contienen y su uso en terapia para el tratamiento de enfermedades inflamatorias. |
-
1998
- 1998-06-23 GB GBGB9813565.0A patent/GB9813565D0/en not_active Ceased
-
1999
- 1999-06-23 AU AU50281/99A patent/AU758979B2/en not_active Ceased
- 1999-06-23 SK SK1953-2000A patent/SK19532000A3/sk unknown
- 1999-06-23 YU YU81000A patent/YU81000A/sh unknown
- 1999-06-23 DE DE69911207T patent/DE69911207D1/de not_active Expired - Lifetime
- 1999-06-23 KR KR1020007014622A patent/KR20010071570A/ko not_active Application Discontinuation
- 1999-06-23 CN CN99809865A patent/CN1313860A/zh active Pending
- 1999-06-23 AT AT99934530T patent/ATE249474T1/de not_active IP Right Cessation
- 1999-06-23 PL PL99345097A patent/PL345097A1/xx unknown
- 1999-06-23 AP APAP/P/2000/002013A patent/AP2000002013A0/en unknown
- 1999-06-23 WO PCT/EP1999/004267 patent/WO1999067264A1/en not_active Application Discontinuation
- 1999-06-23 EE EEP200000764A patent/EE200000764A/xx unknown
- 1999-06-23 NZ NZ508918A patent/NZ508918A/xx unknown
- 1999-06-23 IL IL14028599A patent/IL140285A0/xx unknown
- 1999-06-23 ID IDW20010187A patent/ID28219A/id unknown
- 1999-06-23 JP JP2000555915A patent/JP2002518511A/ja active Pending
- 1999-06-23 BR BR9911488-7A patent/BR9911488A/pt not_active IP Right Cessation
- 1999-06-23 HU HU0102454A patent/HUP0102454A3/hu unknown
- 1999-06-23 TR TR2001/00411T patent/TR200100411T2/xx unknown
- 1999-06-23 CA CA002335758A patent/CA2335758A1/en not_active Abandoned
- 1999-06-23 EP EP99934530A patent/EP1090023B1/en not_active Expired - Lifetime
- 1999-06-23 EA EA200001223A patent/EA200001223A1/ru unknown
-
2000
- 2000-12-14 ZA ZA200007515A patent/ZA200007515B/xx unknown
- 2000-12-15 IS IS5774A patent/IS5774A/is unknown
- 2000-12-20 NO NO20006521A patent/NO20006521L/no not_active Application Discontinuation
- 2000-12-21 HR HR20000895A patent/HRP20000895A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999067264A1 (en) | 1999-12-29 |
GB9813565D0 (en) | 1998-08-19 |
TR200100411T2 (tr) | 2001-07-23 |
ZA200007515B (en) | 2001-12-14 |
AP2000002013A0 (en) | 2000-12-31 |
NO20006521D0 (no) | 2000-12-20 |
HUP0102454A3 (en) | 2003-01-28 |
ATE249474T1 (de) | 2003-09-15 |
KR20010071570A (ko) | 2001-07-28 |
DE69911207D1 (de) | 2003-10-16 |
SK19532000A3 (sk) | 2001-11-06 |
PL345097A1 (en) | 2001-12-03 |
EP1090023A1 (en) | 2001-04-11 |
NO20006521L (no) | 2001-02-22 |
ID28219A (id) | 2001-05-10 |
BR9911488A (pt) | 2001-03-20 |
EE200000764A (et) | 2002-04-15 |
NZ508918A (en) | 2003-03-28 |
HUP0102454A2 (hu) | 2002-01-28 |
EA200001223A1 (ru) | 2001-10-22 |
CA2335758A1 (en) | 1999-12-29 |
JP2002518511A (ja) | 2002-06-25 |
EP1090023B1 (en) | 2003-09-10 |
IS5774A (is) | 2000-12-15 |
AU758979B2 (en) | 2003-04-03 |
AU5028199A (en) | 2000-01-10 |
CN1313860A (zh) | 2001-09-19 |
IL140285A0 (en) | 2002-02-10 |
HRP20000895A2 (en) | 2001-10-31 |
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