YU81000A - Derivati 2-(purin-9-il)-tetrahidrofuran-3,4 diola - Google Patents

Derivati 2-(purin-9-il)-tetrahidrofuran-3,4 diola

Info

Publication number
YU81000A
YU81000A YU81000A YU81000A YU81000A YU 81000 A YU81000 A YU 81000A YU 81000 A YU81000 A YU 81000A YU 81000 A YU81000 A YU 81000A YU 81000 A YU81000 A YU 81000A
Authority
YU
Yugoslavia
Prior art keywords
purin
tetrahydrofuran
diol derivatives
diol
derivatives
Prior art date
Application number
YU81000A
Other languages
English (en)
Inventor
David George Allen
Chuen Chan
Caroline Mary Cook
Richard Peter Charles Cousins
Brian Cox
Hazel Joan Dyke
Frank Ellis
Joanna Victoria Geden
Heather Hobbs
Judith Alison Redgrave
Stephen Swanson
David Bays
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of YU81000A publication Critical patent/YU81000A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

U skladu sa ovim pronalaskom daju se nova jedinjenja formule (I) u kojoj su R1, R2, R3, Z1, Z2, Z3 i Z4 definisani u opisu ove prijave, postupci za njihovo dobijanje i njihova upotreba u postupku dobijanja leka za tretiranje inflamatornih bolesti.[There are provided according to the invention novel compounds of formula (I), wherein R1, R2, R3, Z1, Z2, Z3 and Z4 are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
YU81000A 1998-06-23 1999-06-23 Derivati 2-(purin-9-il)-tetrahidrofuran-3,4 diola YU81000A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9813565.0A GB9813565D0 (en) 1998-06-23 1998-06-23 Chemical compounds

Publications (1)

Publication Number Publication Date
YU81000A true YU81000A (sh) 2003-10-31

Family

ID=10834254

Family Applications (1)

Application Number Title Priority Date Filing Date
YU81000A YU81000A (sh) 1998-06-23 1999-06-23 Derivati 2-(purin-9-il)-tetrahidrofuran-3,4 diola

Country Status (26)

Country Link
EP (1) EP1090023B1 (sh)
JP (1) JP2002518511A (sh)
KR (1) KR20010071570A (sh)
CN (1) CN1313860A (sh)
AP (1) AP2000002013A0 (sh)
AT (1) ATE249474T1 (sh)
AU (1) AU758979B2 (sh)
BR (1) BR9911488A (sh)
CA (1) CA2335758A1 (sh)
DE (1) DE69911207D1 (sh)
EA (1) EA200001223A1 (sh)
EE (1) EE200000764A (sh)
GB (1) GB9813565D0 (sh)
HR (1) HRP20000895A2 (sh)
HU (1) HUP0102454A3 (sh)
ID (1) ID28219A (sh)
IL (1) IL140285A0 (sh)
IS (1) IS5774A (sh)
NO (1) NO20006521L (sh)
NZ (1) NZ508918A (sh)
PL (1) PL345097A1 (sh)
SK (1) SK19532000A3 (sh)
TR (1) TR200100411T2 (sh)
WO (1) WO1999067264A1 (sh)
YU (1) YU81000A (sh)
ZA (1) ZA200007515B (sh)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7214665B2 (en) 2001-10-01 2007-05-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
GB0022695D0 (en) 2000-09-15 2000-11-01 Pfizer Ltd Purine Derivatives
US6670334B2 (en) 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
GB0104555D0 (en) * 2001-02-23 2001-04-11 Glaxo Group Ltd New Therapeutic method
AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
TWI346109B (en) 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
WO2006028618A1 (en) 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
NZ553288A (en) 2004-08-02 2010-12-24 Univ Virginia 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
KR20080049113A (ko) 2005-10-21 2008-06-03 노파르티스 아게 Ｉｌ-13에 대항한 인간 항체 및 치료적 용도
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
ATE502943T1 (de) 2006-09-29 2011-04-15 Novartis Ag Pyrazolopyrimidine als pi3k-lipidkinasehemmer
EP2089393A1 (en) 2006-10-30 2009-08-19 Novartis AG Heterocyclic compounds as antiinflammatory agents
JP5584138B2 (ja) 2008-01-11 2014-09-03 ノバルティス アーゲー キナーゼ阻害剤としてのピリミジン類
JP2012516345A (ja) 2009-01-29 2012-07-19 ノバルティス アーゲー 星細胞腫治療用置換ベンゾイミダゾール
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
AU2010283806A1 (en) 2009-08-12 2012-03-01 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
ES2709108T3 (es) 2009-08-17 2019-04-15 Intellikine Llc Compuestos heterocíclicos y usos de los mismos
AU2010284972A1 (en) 2009-08-20 2012-03-08 Novartis Ag Heterocyclic oxime compounds
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
EP2673277A1 (en) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
US9127000B2 (en) 2011-02-23 2015-09-08 Intellikine, LLC. Heterocyclic compounds and uses thereof
WO2012116217A1 (en) 2011-02-25 2012-08-30 Irm Llc Compounds and compositions as trk inhibitors
BR112014006223A8 (pt) 2011-09-15 2018-01-09 Novartis Ag 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação
JP6130391B2 (ja) 2011-11-23 2017-05-17 インテリカイン， エルエルシー Ｍｔｏｒ阻害剤を使用する強化された治療レジメン
CN104245701A (zh) 2012-04-03 2014-12-24 诺华有限公司 有酪氨酸激酶抑制剂的组合产品和其应用
EP2968340A4 (en) 2013-03-15 2016-08-10 Intellikine Llc COMBINING KINASE INHIBITORS AND USES THEREOF
WO2015084804A1 (en) 2013-12-03 2015-06-11 Novartis Ag Combination of mdm2 inhibitor and braf inhibitor and their use
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
MX2017001461A (es) 2014-07-31 2017-05-11 Novartis Ag Terapia de combinacion.
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
WO1998001459A1 (en) * 1996-07-05 1998-01-15 Novo Nordisk A/S Novel n-alkoxyadenine derivatives acting as cytokine inhibitors
TW528755B (en) * 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) * 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
AR017457A1 (es) * 1998-02-14 2001-09-05 Glaxo Group Ltd Compuestos derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol, procesos para su preparacion, composiciones que los contienen y su uso en terapia para el tratamiento de enfermedades inflamatorias.

Also Published As

Publication number Publication date
WO1999067264A1 (en) 1999-12-29
GB9813565D0 (en) 1998-08-19
TR200100411T2 (tr) 2001-07-23
ZA200007515B (en) 2001-12-14
AP2000002013A0 (en) 2000-12-31
NO20006521D0 (no) 2000-12-20
HUP0102454A3 (en) 2003-01-28
ATE249474T1 (de) 2003-09-15
KR20010071570A (ko) 2001-07-28
DE69911207D1 (de) 2003-10-16
SK19532000A3 (sk) 2001-11-06
PL345097A1 (en) 2001-12-03
EP1090023A1 (en) 2001-04-11
NO20006521L (no) 2001-02-22
ID28219A (id) 2001-05-10
BR9911488A (pt) 2001-03-20
EE200000764A (et) 2002-04-15
NZ508918A (en) 2003-03-28
HUP0102454A2 (hu) 2002-01-28
EA200001223A1 (ru) 2001-10-22
CA2335758A1 (en) 1999-12-29
JP2002518511A (ja) 2002-06-25
EP1090023B1 (en) 2003-09-10
IS5774A (is) 2000-12-15
AU758979B2 (en) 2003-04-03
AU5028199A (en) 2000-01-10
CN1313860A (zh) 2001-09-19
IL140285A0 (en) 2002-02-10
HRP20000895A2 (en) 2001-10-31

Similar Documents

Publication Publication Date Title
AP2000002013A0 (en) 2-(Purin-9-yl) -tetrahydrofuran-3, 4-diol derivatives.
AP2000001875A0 (en) 2-(Purin-9-yl)-tetrahydrofuran -3,4-diol derivatives.
YU29099A (sh) Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola
AP2000002016A0 (en) 2-(Purin-9-yl) Tetrahydrofuran-3,4-diol derivatives.
YU50800A (sh) Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola
AU4613999A (en) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
TW200500358A (en) Compounds
YU45403A (sh) Novi 1,2-difenil-azetidinoni, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena za lečenje poremećaja u metabolizmu lipida
TR200101709T2 (tr) İltihabik hastalıkların tedavisinde yararlı olan bileşikler
AU2002218167A1 (en) N-phenyl-2-pyrimidine-amine derivatives
MXPA02007942A (es) Derivados de pirrolopirimidinona, procesos de preparacion y uso.
PL373414A1 (en) 8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands
MXPA04000577A (es) Derivados de dolastatina 10.
AP1408A (en) Phenyl yanthine derivatives.
YU60900A (sh) Novi kristalni oblici antivirusnog benzimidazolskog jedinjenja
AP2001002191A0 (en) 3,3- Biarylpiperine and 2,2-biarylmorpholine derivatives.
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
MXPA02012426A (es) Compuestos nuevos.
DE69911785D1 (de) Triazolo[4,5-d]pyrimidin-verbindungen
MX9800049A (es) Antraquinonas mono- y disulfo-substituidas y su uso para el tratamiento de trastornos de la matriz del hueso.
AU6826700A (en) Ceramide analogs, process for their preparation and their use as antitumor agents
AP2000001760A0 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
AU2001234314A1 (en) Novel phenylheteroalkylamine derivatives
AU2001266019A1 (en) 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivatives