YU76593A - 1-SUPST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL) -1,4-DIHYDROHINOLINES-3-CARBOXYLIC ACIDS, A NEW INTERMEDIATE USED IN THIS PROCEDURE AND A PROCEDURE FOR OBTAINING INTERMEDIATE - Google Patents

1-SUPST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL) -1,4-DIHYDROHINOLINES-3-CARBOXYLIC ACIDS, A NEW INTERMEDIATE USED IN THIS PROCEDURE AND A PROCEDURE FOR OBTAINING INTERMEDIATE

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Publication number
YU76593A
YU76593A YU76593A YU76593A YU76593A YU 76593 A YU76593 A YU 76593A YU 76593 A YU76593 A YU 76593A YU 76593 A YU76593 A YU 76593A YU 76593 A YU76593 A YU 76593A
Authority
YU
Yugoslavia
Prior art keywords
procedure
oxo
fluoro
piperazinyl
dihydrohinolines
Prior art date
Application number
YU76593A
Other languages
Serbo-Croatian (sh)
Inventor
N. Župančič
M. Barbo
B. Šket
P. Zupet
Original Assignee
Krka Tovarna Zdravil P.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil P.O. filed Critical Krka Tovarna Zdravil P.O.
Publication of YU76593A publication Critical patent/YU76593A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE 1-SUPST.-6-FLUORO-4-OKSO-7-(1-PIPERAZINIL)-1,4-DIHIDROHINOLINI-3-KARBOKSILNE KISELINE, NOVI INTERMEDIJER UPOTREBLJEN U TOM POSTUPKU I POSTUPAK ZA DOBIJANJE INTERMEDIJARA, opisan je postupak dobijanja 1-supst.-6-fluoro-4-okso-7-(1-piperazinil)-1,4-dihidrokinolin-3-karboksilne kiseline formule II gde R1 označava niži alkil, niži cikloalkil ili 2,4-difluorofenil, kod koga 1-supst.-6-fluoro-4-okso-7-(4-supst.-1-piperazinil)-1,4-dihidrokinolin-3-karboksilat diacetata bora formule I hidrolizujemo u alkalnom. Jedinjenja formule II se upotrebljavaju u medicini za lečenje inflamatornih oboljenja. Jedinjenje formule I je novo. Dobijamo ga nukleofilnom supstitucijom atoma halogena na mestu 7 u 1-supstituisanom-6-fluoro-4-okso-7-halo-1,4-dihidrokinolin-3-karboksilatu diacetata bora s 1-supstituiranim piperazinom.PROCEDURE FOR OBTAINING 1-SUBST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL) -1,4-DIHYDROHINOLINES-3-CARBOXYLIC ACIDS, A NEW INTERMEDIATE USED IN THIS PROCEDURE to obtain 1-substituted-6-fluoro-4-oxo-7- (1-piperazinyl) -1,4-dihydroquinoline-3-carboxylic acid of formula II wherein R 1 is lower alkyl, lower cycloalkyl or 2,4-difluorophenyl, at whose 1-subst.-6-fluoro-4-oxo-7- (4-subst-1-piperazinyl) -1,4-dihydroquinoline-3-carboxylate diacetate boron of formula I is hydrolyzed in alkali. The compounds of formula II are used in medicine for the treatment of inflammatory diseases. The compound of formula I is novel. It is obtained by nucleophilic substitution of halogen at site 7 in 1-substituted-6-fluoro-4-oxo-7-halo-1,4-dihydroquinoline-3-carboxylate boron diacetate with 1-substituted piperazine.

YU76593A 1992-12-11 1993-12-10 1-SUPST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL) -1,4-DIHYDROHINOLINES-3-CARBOXYLIC ACIDS, A NEW INTERMEDIATE USED IN THIS PROCEDURE AND A PROCEDURE FOR OBTAINING INTERMEDIATE YU76593A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9200377A SI9200377A (en) 1992-12-11 1992-12-11 Process for the preparation of 1-substituted 6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxilic acid, novel intermediate used in this process and process for its preparation

Publications (1)

Publication Number Publication Date
YU76593A true YU76593A (en) 1996-07-24

Family

ID=20431064

Family Applications (1)

Application Number Title Priority Date Filing Date
YU76593A YU76593A (en) 1992-12-11 1993-12-10 1-SUPST.-6-FLUORO-4-OXO-7- (1-PIPERAZINYL) -1,4-DIHYDROHINOLINES-3-CARBOXYLIC ACIDS, A NEW INTERMEDIATE USED IN THIS PROCEDURE AND A PROCEDURE FOR OBTAINING INTERMEDIATE

Country Status (13)

Country Link
AT (1) AT401648B (en)
CA (1) CA2111181A1 (en)
CZ (1) CZ284715B6 (en)
EE (1) EE9400277A (en)
HR (1) HRP931485A2 (en)
HU (1) HUT75319A (en)
LT (1) LT3084B (en)
LV (1) LV10863B (en)
PL (1) PL173784B1 (en)
RU (1) RU2127270C1 (en)
SI (1) SI9200377A (en)
SK (1) SK140093A3 (en)
YU (1) YU76593A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2307919T3 (en) * 2002-03-27 2008-12-01 Glaxo Group Limited DERIVATIVES OF QUINOLINA AND ITS USE AS LIGANDS OF 5-HT6.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE444566B (en) 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-DIALKYLAMINE-6-HALOGEN-4-OXO-1,4-DIHYDROQINOLINE-3-CARBOXYLIC ACID, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION OF THEREOF
DE2747357A1 (en) 1977-10-21 1979-04-26 Bayer Ag SUBSTITUTED PYRIMIDINYL (THIONO) (THIOL) PHOSPHOR (PHOSPHON) ACID ESTERS OR. -ESTERAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS INSECTICIDES AND ACARICIDES
JPS5533453A (en) 1978-08-31 1980-03-08 Dainippon Pharmaceut Co Ltd Preventive and remedy for infectious disease of fish
JPS5762259A (en) 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
DE3308909A1 (en) 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen BACTERICIDALS BASED ON CHINOLONIC CARBONIC ACID
DE8812756U1 (en) 1988-09-22 1988-12-01 Weinschlauch Hemü Weinhandel GmbH, 4000 Düsseldorf Tap cabinet

Also Published As

Publication number Publication date
CA2111181A1 (en) 1994-06-12
EE9400277A (en) 1996-04-15
LV10863A (en) 1995-10-20
LV10863B (en) 1996-08-20
LTIP1558A (en) 1994-06-15
HU9302940D0 (en) 1993-12-28
SK140093A3 (en) 1994-11-09
ATA249793A (en) 1996-03-15
PL173784B1 (en) 1998-04-30
AT401648B (en) 1996-10-25
CZ264393A3 (en) 1994-07-13
SI9200377A (en) 1994-06-30
HUT75319A (en) 1997-05-28
HRP931485A2 (en) 1995-04-30
LT3084B (en) 1994-11-25
PL301045A1 (en) 1994-06-13
CZ284715B6 (en) 1999-02-17
RU2127270C1 (en) 1999-03-10

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