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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority claimed from US470917Aexternal-prioritypatent/US3341541A/en
Application filed by F Hoffmann La Roche AGfiledCriticalF Hoffmann La Roche AG
Publication of ES319475A1publicationCriticalpatent/ES319475A1/en
A process for the preparation of benzylpyrimidines of the general formula ** (See formula) ** wherein R1 is hydrogen, methyl, chloro or methoxy; R2 is hydrogen, chloro or methoxy and R3 and R4 are each halogen, methyl or lower alkoxy, characterized in that it comprises the steps of: (a) reacting an aldehyde of the general formula ** (See formula) ** with a compound of the general formula NC - CH2CH2 OR (III) in the presence of a lower alkali metal alkoxide and a lower alkanol of the formula R'OH, to form a compound of the formula ** (See formula) ** and (b) reacting said compound of formula IV with guanidine, to obtain a compound of formula I, wherein in the above formulas the meaning of R1, R2, R3 and R4 is the same as that stated for the compound of the formula I, while R and R 'are lower alkyl. (Machine-translation by Google Translate, not legally binding)
ES0319475A1964-11-121965-11-11A procedure for the preparation of bencil pyrimidines. (Machine-translation by Google Translate, not legally binding)
ExpiredES319475A1
(en)
Procedure for the preparation of new 2-alcoxy-5-fe- nil-4h-3,5-dihidro-1,5-benzodiazepin-4-onas. (Machine-translation by Google Translate, not legally binding)