YU74103A - Topoizomeraza i selektivni citotoksični šećerni derivati indolopirolokarbazola - Google Patents

Topoizomeraza i selektivni citotoksični šećerni derivati indolopirolokarbazola

Info

Publication number
YU74103A
YU74103A YU74103A YUP74103A YU74103A YU 74103 A YU74103 A YU 74103A YU 74103 A YU74103 A YU 74103A YU P74103 A YUP74103 A YU P74103A YU 74103 A YU74103 A YU 74103A
Authority
YU
Yugoslavia
Prior art keywords
indolopyrrolocarbazoles
topoisomerase
sugar derivatives
selective cytotoxic
sugar
Prior art date
Application number
YU74103A
Other languages
English (en)
Inventor
Edward H. Ruediger
Mark G. Saulnier
Carol Bachand
Francis Beaulieu
Neelakantan Balusubramanian
Byron Hepler Long
David B. Frennesson
Kurt Zimmerman
Narasimhulu B. Naidu
Karen Stoffan
Denis Robert St. Laurent
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of YU74103A publication Critical patent/YU74103A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Ovaj pronalazak se odnosi na fluoro šećerne i druge šećerne derivate indolopirolokarbazola, njihove soli i hidrate, koji pokazuju selektivnu topoizomeraza I aktivnost, koji su korisni za inhibiciju proliferacije tumornih ćelija i pokazuju antitumorno dejstvo, kao takodje i na postupke za njihovo dobijanje.[The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.
YU74103A 2001-03-22 2002-03-22 Topoizomeraza i selektivni citotoksični šećerni derivati indolopirolokarbazola YU74103A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27804301P 2001-03-22 2001-03-22

Publications (1)

Publication Number Publication Date
YU74103A true YU74103A (sh) 2006-05-25

Family

ID=23063451

Family Applications (1)

Application Number Title Priority Date Filing Date
YU74103A YU74103A (sh) 2001-03-22 2002-03-22 Topoizomeraza i selektivni citotoksični šećerni derivati indolopirolokarbazola

Country Status (22)

Country Link
US (1) US6855698B2 (sh)
EP (1) EP1370673A4 (sh)
JP (1) JP2004534006A (sh)
KR (1) KR20030085035A (sh)
CN (1) CN1509335A (sh)
BG (1) BG108183A (sh)
BR (1) BR0208322A (sh)
CA (1) CA2441412A1 (sh)
CZ (1) CZ20032876A3 (sh)
EE (1) EE200300456A (sh)
HR (1) HRP20030761A2 (sh)
HU (1) HUP0400265A2 (sh)
IL (1) IL157909A0 (sh)
IS (1) IS6958A (sh)
MX (1) MXPA03008589A (sh)
NO (1) NO20034190L (sh)
PL (1) PL368942A1 (sh)
RU (1) RU2003131269A (sh)
SK (1) SK12022003A3 (sh)
WO (1) WO2002077255A1 (sh)
YU (1) YU74103A (sh)
ZA (1) ZA200307317B (sh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487925A (en) 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4552842A (en) 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4567143A (en) * 1984-09-04 1986-01-28 Bristol-Myers Company Process for preparing 4'-deschlororebeccamycin
US4785085A (en) 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
JP2766360B2 (ja) 1988-02-04 1998-06-18 協和醗酵工業株式会社 スタウロスポリン誘導体
DE3803620A1 (de) 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3924538A1 (de) 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazol und dessen verwendung
US5618809A (en) 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
IL97233A (en) 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them
US5478813A (en) 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
CA2123895A1 (en) * 1992-09-21 1994-03-31 Tatsuya Tamaoki A therapeutic agent for thrombocytopenia
FR2696465B1 (fr) 1992-10-02 1994-12-23 Adir Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JP3603322B2 (ja) 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5468872A (en) 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
WO1995030682A1 (fr) 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Derive d'indolopyrolocarbazole antitumoral
AU3086495A (en) 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
US5705511A (en) 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
AU6888196A (en) * 1995-08-11 1997-03-12 Yale University Glycosylated indolocarbazole synthesis
DK0971717T3 (da) * 1996-08-22 2002-03-25 Bristol Myers Squibb Co Cytotoksiske aminosukker- og relaterede sukkerderivater af indolopyrrolocarbazoler
CO4940430A1 (es) 1997-07-07 2000-07-24 Novartis Ag Compuestos policiclicos que contienen estaurosporina hidrogenada con propiedades farmacologicas convenientes y un efecto inhibidor sobre el crecimiento de las celulas tumorales
FR2801054B1 (fr) 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
KR20030085035A (ko) 2003-11-01
RU2003131269A (ru) 2005-05-10
PL368942A1 (en) 2005-04-04
NO20034190D0 (no) 2003-09-19
JP2004534006A (ja) 2004-11-11
MXPA03008589A (es) 2003-12-08
CN1509335A (zh) 2004-06-30
US20030083271A1 (en) 2003-05-01
IL157909A0 (en) 2004-03-28
SK12022003A3 (sk) 2004-05-04
NO20034190L (no) 2003-11-19
EP1370673A4 (en) 2006-08-09
HUP0400265A2 (hu) 2004-08-30
CZ20032876A3 (en) 2004-03-17
BG108183A (en) 2004-07-30
BR0208322A (pt) 2004-10-13
CA2441412A1 (en) 2002-10-03
EE200300456A (et) 2004-02-16
HRP20030761A2 (en) 2004-04-30
ZA200307317B (en) 2004-12-20
EP1370673A1 (en) 2003-12-17
WO2002077255A1 (en) 2002-10-03
US6855698B2 (en) 2005-02-15
IS6958A (is) 2003-09-16

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