YU63496A - Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanje - Google Patents

Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanje

Info

Publication number
YU63496A
YU63496A YU63496A YU63496A YU63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
optionally substituted
alkyl
denotes
group
Prior art date
Application number
YU63496A
Other languages
English (en)
Inventor
Imre Bata
Sandor Batori
Judit Bence
Zsolt Bocskei
Eva Csikos
Sandor Erdo
Csaba Gonczi
Istvan Hermecz
Gergely Heja
Viktor Lakicz
Csilla Majlath
Peter Molnar
Benjamin Podanyi
Imola Ritz
Csutor Andrea Santane
Szappanos Andrea Szokene
Gyorgyne Szvoboda
Original Assignee
Chinoin, Gyogyszer Es Vegyeszeti Termekek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin, Gyogyszer Es Vegyeszeti Termekek filed Critical Chinoin, Gyogyszer Es Vegyeszeti Termekek
Publication of YU63496A publication Critical patent/YU63496A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/54—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pronalazak se odnosi na nove 3-amino-hinoksalin-2-on derivate opste formule I, na njihove soli, tautomerne oblike i N-okside, na farmaceutske preparate koji sadrze ova jedinjenja i na postupak za njihovo dobijanje, gde Z1 oznacava vodonik, hidroksi, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil, COOC1-4 alkil, C2-14 acil, C1-4 alkilsulfonil, trifluorometil-sulfonil, po izboru supstituisanu benzoil, i po izboru supstituisanu fenil-sulfonil grupu; Y1 oznacava vodonik ili po izboru supstituisanu amino grupu ili Y1 i Z1 grade zajedno -CO-O- grupu gde Y2 i Z2 oznacavaju zajedno valentnu vezu ili Y1 i Y2 oznacavaju zajedno valentnu vezu, i u isto vreme Z2 oznacava vodonik, hidroksi, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil, COOC1-4 alkil, C2-14 acil, C1-4 alkilsulfonil, trifluorometil-sulfonil, po izboru supstituisanu benzoil, i po izboru supstituisanu fenil-sulfonil grupu; X1 i X2 oznacavaju zajedno =O ili =S ili X1 oznacava vodonik, -NHR4 ili -WR5 grupe i u isto vreme X2 oznacava vodonik ili X2 i X3 zajedno grade valentnu vezu; X3 oznacava vodonik, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil grupu; R1 i R2 oznacavaju vodonik, halogen, C1-4 alkil, trifluorometil, cijano, merkapto ili sulfonilamido grupu; R3 oznacava vodonik ili nitro grupu; R4 oznacava vodonik ili hidroksi grupu; R5 oznacava vodonik, C1-4 alkil, C7-9 fenilalkil grupu; W oznacava kiseonik ili sumpor, uz pretpostavku, da a) ako bar jedan od supstituenata R1, R2 i R3 nije vodonik ili b) ako znacenja Z1 i Z2 su vodonik, tada R1 je 6-hloro, R3 je vodonik, R2 nije 7-hloro ili R1 je 6-metil, R3 je vodonik, R2 nije 7-metil, jedinjenja opste formule I pokazuju znacajnu aktivnost na glicin vezujuce mesto NMDA receptora i stoga se mogu koristiti kao aktivni sastojci farmaceutskih preparata.
YU63496A 1995-11-30 1996-11-28 Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanje YU63496A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9503422A HUT76302A (en) 1995-11-30 1995-11-30 Quinoxaline derivatives, pharmaceutical compositions containing them and process for producing them

Publications (1)

Publication Number Publication Date
YU63496A true YU63496A (sh) 1999-03-04

Family

ID=10987414

Family Applications (1)

Application Number Title Priority Date Filing Date
YU63496A YU63496A (sh) 1995-11-30 1996-11-28 Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanje

Country Status (6)

Country Link
AU (1) AU7705396A (sh)
HR (1) HRP960564A2 (sh)
HU (1) HUT76302A (sh)
WO (1) WO1997019934A1 (sh)
YU (1) YU63496A (sh)
ZA (1) ZA9610002B (sh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL139783A0 (en) 1998-06-01 2002-02-10 Shionogi & Co Cyanoiminoquinoxaline derivates
MXPA01007001A (es) 1999-01-11 2002-07-30 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas.
US6927214B1 (en) * 1999-01-15 2005-08-09 Novo Nordisk A/S Non-peptide GLP-1 agonists
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
US7365209B2 (en) 2003-02-11 2008-04-29 Pharmacopeia, Inc. Nitrogen heterocycle biaryls for osteoporosis and other diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3446809A (en) * 1966-01-19 1969-05-27 Eastman Kodak Co Process for the preparation of 2-amino-3-hydroxyquinoxalines
EP0030795A3 (en) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore

Also Published As

Publication number Publication date
HU9503422D0 (en) 1996-01-29
HRP960564A2 (en) 1998-02-28
HUT76302A (en) 1997-07-28
ZA9610002B (en) 1997-06-13
AU7705396A (en) 1997-06-19
WO1997019934A1 (en) 1997-06-05

Similar Documents

Publication Publication Date Title
YU13396A (sh) N-(3-benzofuranil) urea derivati, postupci za njihovo dobijanje, kompozicije koje ih sadrže i njihova upotreba u lekovima
FI934274A0 (fi) N-sulfonyl-2-oxi-indolderivat, deras framstaellning och dessa innehaollande farmaceutiska kompositioner
FI931600A (fi) Pyridiner och pyridin-N-oxidderivat av diarylmetylpiperidiner eller piperaziner, och foereningar och foerfarande foer deras anvaendning
ES8401027A1 (es) Procedimiento para la obtencion de acidos 1-carboxi-(alcanoil o aralcanoil)-indolin-2-carboxilicos.
ES2057628T3 (es) Composiciones de omeprazol diseñadas para administracion rectal y su proceso de preparacion.
ES2175624T3 (es) Derivados de pirazolo(4,3-d)pirimidina y composiciones farmaceuticas que los contienen.
AR245447A1 (es) Procedimiento para preparar derivados de 2,4-diamino-5-(biciclo-sustituido)metilpirimidinas.
FI960504A (fi) Menetelmä terapeuttisten yhdisteiden ja rasvahappojen muodostamien konjugaattien valmistamiseksi
ATE29255T1 (de) Succinimid-derivate und deren herstellung.
DK27383A (da) Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
PT1254134E (pt) Derivados de 1,3-di-hidro-2h-indol-2-ona e sua utilizacao como ligandos para os receptores v1b ou v1b e v1a da arginina-vasopressina
YU30197A (sh) Derivati 4-hidroksi-piperidina, lekovi koji ih sadrže i postupci za njihovu proizvodnju
TR199701647A2 (xx) �kame edilmi� purin t�revleri,bunlar�n imalat usul�
ES2081178T3 (es) Compuestos anti-tumorales que contienen anillos quinazolina y tetrazol.
YU4795A (sh) Derivati indola koji se mogu koristiti kao 5ht agonisti, farmaceutski preparati koji ih sadrže i postupci njihovog dobijanja
ATE22891T1 (de) Pyrimidinonderivate und diese enthaltende pharmazeutische zusammensetzungen.
TNSN97014A1 (fr) Piperidones, procedes pour leur preparation et compositions pharmaceutiques les contenant.
YU63496A (sh) Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanje
EA200300044A1 (ru) Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
ATE3284T1 (de) Derivate der 9-cis-6,6'-diapo-psi,psicarotindis[ure, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
IL162314A (en) Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation, pharmaceutical compositions comprising them and uses thereof
ATE253359T1 (de) Antithrombotische mittel
DK179788A (da) N-aryl-piperazinalkanamidderivater, fremgangsmaade til fremstilling deraf, praeparater indeholdende samme samt anvendelse af saadanne derivater til fremstilling af farmaceutisk aktive praeparater
GB1530413A (en) 5,8-dihydro-5-oxopyrido(2,3-d)pyrimidines