YU63496A - Novel compounds, farmacutical prepartions containing them and a process for the preparation thereof - Google Patents
Novel compounds, farmacutical prepartions containing them and a process for the preparation thereofInfo
- Publication number
- YU63496A YU63496A YU63496A YU63496A YU63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hydrogen
- optionally substituted
- alkyl
- denotes
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/54—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Abstract
Pronalazak se odnosi na nove 3-amino-hinoksalin-2-on derivate opste formule I, na njihove soli, tautomerne oblike i N-okside, na farmaceutske preparate koji sadrze ova jedinjenja i na postupak za njihovo dobijanje, gde Z1 oznacava vodonik, hidroksi, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil, COOC1-4 alkil, C2-14 acil, C1-4 alkilsulfonil, trifluorometil-sulfonil, po izboru supstituisanu benzoil, i po izboru supstituisanu fenil-sulfonil grupu; Y1 oznacava vodonik ili po izboru supstituisanu amino grupu ili Y1 i Z1 grade zajedno -CO-O- grupu gde Y2 i Z2 oznacavaju zajedno valentnu vezu ili Y1 i Y2 oznacavaju zajedno valentnu vezu, i u isto vreme Z2 oznacava vodonik, hidroksi, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil, COOC1-4 alkil, C2-14 acil, C1-4 alkilsulfonil, trifluorometil-sulfonil, po izboru supstituisanu benzoil, i po izboru supstituisanu fenil-sulfonil grupu; X1 i X2 oznacavaju zajedno =O ili =S ili X1 oznacava vodonik, -NHR4 ili -WR5 grupe i u isto vreme X2 oznacava vodonik ili X2 i X3 zajedno grade valentnu vezu; X3 oznacava vodonik, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil grupu; R1 i R2 oznacavaju vodonik, halogen, C1-4 alkil, trifluorometil, cijano, merkapto ili sulfonilamido grupu; R3 oznacava vodonik ili nitro grupu; R4 oznacava vodonik ili hidroksi grupu; R5 oznacava vodonik, C1-4 alkil, C7-9 fenilalkil grupu; W oznacava kiseonik ili sumpor, uz pretpostavku, da a) ako bar jedan od supstituenata R1, R2 i R3 nije vodonik ili b) ako znacenja Z1 i Z2 su vodonik, tada R1 je 6-hloro, R3 je vodonik, R2 nije 7-hloro ili R1 je 6-metil, R3 je vodonik, R2 nije 7-metil, jedinjenja opste formule I pokazuju znacajnu aktivnost na glicin vezujuce mesto NMDA receptora i stoga se mogu koristiti kao aktivni sastojci farmaceutskih preparata.The invention relates to novel 3-amino-quinoxalin-2-one derivatives of general formula I, to their salts, tautomeric forms and N-oxides, to pharmaceutical preparations containing these compounds and to a process for their preparation, wherein Z 1 denotes hydrogen, hydroxy , C1-4 alkyl, C7-9 phenylalkyl optionally substituted phenyl, COOC1-4 alkyl, C2-14 acyl, C1-4 alkylsulfonyl, trifluoromethylsulfonyl, optionally substituted benzoyl, and optionally substituted phenylsulfonyl; Y1 denotes hydrogen or an optionally substituted amino group or Y1 and Z1 form together a -CO-O- group where Y2 and Z2 denote together a valence bond or Y1 and Y2 denote together a valence bond and at the same time Z2 denotes hydrogen, hydroxy, C1-4 alkyl, C7-9 phenylalkyl optionally substituted phenyl, COOC1-4 alkyl, C2-14 acyl, C1-4 alkylsulfonyl, trifluoromethylsulfonyl, optionally substituted benzoyl, and optionally substituted phenylsulfonyl; X1 and X2 denote together = O or = S or X1 denotes hydrogen, -NHR4 or -WR5 groups and at the same time X2 denotes hydrogen or X2 and X3 together form a valence bond; X3 denotes hydrogen, C1-4 alkyl, C7-9 phenylalkyl, optionally substituted phenyl group; R 1 and R 2 represent hydrogen, halogen, C 1-4 alkyl, trifluoromethyl, cyano, mercapto or sulfonylamido group; R3 denotes hydrogen or a nitro group; R4 denotes a hydrogen or hydroxy group; R5 denotes hydrogen, a C1-4 alkyl, a C7-9 phenylalkyl group; W denotes oxygen or sulfur, assuming that a) if at least one of the substituents R1, R2 and R3 is not hydrogen or b) if the meanings Z1 and Z2 are hydrogen, then R1 is 6-chloro, R3 is hydrogen, R2 is not 7- chloro or R1 is 6-methyl, R3 is hydrogen, R2 is not 7-methyl, the compounds of general formula I show significant activity on the glycine binding site of the NMDA receptor and can therefore be used as active ingredients in pharmaceutical preparations.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9503422A HUT76302A (en) | 1995-11-30 | 1995-11-30 | Quinoxaline derivatives, pharmaceutical compositions containing them and process for producing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU63496A true YU63496A (en) | 1999-03-04 |
Family
ID=10987414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU63496A YU63496A (en) | 1995-11-30 | 1996-11-28 | Novel compounds, farmacutical prepartions containing them and a process for the preparation thereof |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU7705396A (en) |
| HR (1) | HRP960564A2 (en) |
| HU (1) | HUT76302A (en) |
| WO (1) | WO1997019934A1 (en) |
| YU (1) | YU63496A (en) |
| ZA (1) | ZA9610002B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304404A (en) * | 1998-06-01 | 2001-07-18 | 盐野义制药株式会社 | Cyanoiminoquinoxaline derivatives |
| EP1140936B1 (en) | 1999-01-11 | 2004-03-17 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
| US6927214B1 (en) * | 1999-01-15 | 2005-08-09 | Novo Nordisk A/S | Non-peptide GLP-1 agonists |
| ECSP003637A (en) | 1999-08-31 | 2002-03-25 | Agouron Pharma | TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES |
| US7365209B2 (en) | 2003-02-11 | 2008-04-29 | Pharmacopeia, Inc. | Nitrogen heterocycle biaryls for osteoporosis and other diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3446809A (en) * | 1966-01-19 | 1969-05-27 | Eastman Kodak Co | Process for the preparation of 2-amino-3-hydroxyquinoxalines |
| EP0030795A3 (en) * | 1979-12-06 | 1981-09-09 | Imperial Chemical Industries Plc | Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives |
| US5597922A (en) * | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
-
1995
- 1995-11-30 HU HU9503422A patent/HUT76302A/en unknown
-
1996
- 1996-11-27 HR HRP960564 patent/HRP960564A2/en not_active Application Discontinuation
- 1996-11-28 WO PCT/HU1996/000072 patent/WO1997019934A1/en active Application Filing
- 1996-11-28 ZA ZA9610002A patent/ZA9610002B/en unknown
- 1996-11-28 YU YU63496A patent/YU63496A/en unknown
- 1996-11-28 AU AU77053/96A patent/AU7705396A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HU9503422D0 (en) | 1996-01-29 |
| HUT76302A (en) | 1997-07-28 |
| AU7705396A (en) | 1997-06-19 |
| ZA9610002B (en) | 1997-06-13 |
| WO1997019934A1 (en) | 1997-06-05 |
| HRP960564A2 (en) | 1998-02-28 |
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