YU57795A - Kristalni oblik derivata dihidro-2,3-benzodiazepina - Google Patents

Kristalni oblik derivata dihidro-2,3-benzodiazepina

Info

Publication number
YU57795A
YU57795A YU57795A YU57795A YU57795A YU 57795 A YU57795 A YU 57795A YU 57795 A YU57795 A YU 57795A YU 57795 A YU57795 A YU 57795A YU 57795 A YU57795 A YU 57795A
Authority
YU
Yugoslavia
Prior art keywords
dihidro
benzodiazepine derivatives
crystal form
benzodiazepine
dihydro
Prior art date
Application number
YU57795A
Other languages
English (en)
Other versions
YU49289B (sh
Inventor
Anderson
Hansen
Vicenzi
Varie
Zmijewski
Groleak
Original Assignee
Eli Lilly And Company Indianapolis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company Indianapolis filed Critical Eli Lilly And Company Indianapolis
Publication of YU57795A publication Critical patent/YU57795A/sh
Publication of YU49289B publication Critical patent/YU49289B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Ovaj pronalazak se, odnosi na nove fizičke oblike derivata dihidro-2,3-benzodiazepina koji su korisni kao lekovi u lečenju poremećaja nervnog sistema. Sadašnji pronalazak obezbeđuje fizičke oblike (R)-7-acetil-5-(4-aminofenil)-8,8-dihidro-8-metil-7H-1,3-dioksolo [4,5-h] [2,3] benzodiazepina koji ima difrakciju X-zraka u sprašenom stanju sa d rastojanjima na 12.78, 9.48, 8.99, 8.64, 8.23, 6.39, 6.27, 5.73, 4.01 i 3.96 A. Pronalazak takođje obezbeđjuje postupak za dobijanje ovog oblika i farmaceutske kompozicije koje ga sadrže.
YU57795A 1994-08-31 1995-08-30 Kristalni oblik derivata dihidro-2,3-benzodiazepina YU49289B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29864594A 1994-08-31 1994-08-31
US08/412,242 US6329364B1 (en) 1994-08-31 1995-03-28 Crystalline form of dihydro-2,3-benzodiazepine derivative

Publications (2)

Publication Number Publication Date
YU57795A true YU57795A (sh) 1998-07-10
YU49289B YU49289B (sh) 2005-03-15

Family

ID=23151416

Family Applications (3)

Application Number Title Priority Date Filing Date
YU57695A YU49288B (sh) 1994-08-31 1995-08-30 (r)-enantiomer derivata dihidro-2,3-benzodiazepina
YU57895A YU49349B (sh) 1994-08-31 1995-08-30 Stereoselektivni postupak za dobijanje derivata dihidro -2,3- benzodiazepina
YU57795A YU49289B (sh) 1994-08-31 1995-08-30 Kristalni oblik derivata dihidro-2,3-benzodiazepina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
YU57695A YU49288B (sh) 1994-08-31 1995-08-30 (r)-enantiomer derivata dihidro-2,3-benzodiazepina
YU57895A YU49349B (sh) 1994-08-31 1995-08-30 Stereoselektivni postupak za dobijanje derivata dihidro -2,3- benzodiazepina

Country Status (13)

Country Link
US (3) US6288057B1 (sh)
KR (2) KR100386933B1 (sh)
CO (3) CO4410199A1 (sh)
HU (1) HU223846B1 (sh)
MY (2) MY117754A (sh)
NZ (1) NZ272896A (sh)
PE (3) PE32896A1 (sh)
RU (1) RU2142465C1 (sh)
SI (2) SI0699677T1 (sh)
TW (3) TW372965B (sh)
UA (3) UA44698C2 (sh)
YU (3) YU49288B (sh)
ZA (3) ZA957279B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT651746E (pt) * 1992-07-24 2002-09-30 Univ California Drogas que intensificam as respostas sinapticas mediadas por receptores de ampa
KR100478129B1 (ko) * 1996-12-20 2005-12-26 주식회사 효성 투습방수직물의제조방법
BR0211061A (pt) * 2001-07-10 2004-07-20 Upjohn Co Cristais de tiazina oxazolidinonas e processos para isolar tais cristais
DK3168218T3 (en) * 2001-08-15 2019-01-14 Pharmacia & Upjohn Co Llc Crystalline comprising an L-malic acid salt of N- [2- (DIETHYLAMINO) ETHYL] -5 - [(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDE) METHYL] -2,4 -DIMETHYL-1H-PYRROL-3-CARBOXAMIDE FOR USE AS A MEDICINE
KR20040032188A (ko) * 2002-10-01 2004-04-17 기아자동차주식회사 개량형 아웃사이드 미러
WO2007077469A1 (en) * 2005-12-30 2007-07-12 Egis Gyógyszergyár Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
US20160137573A1 (en) * 2014-11-14 2016-05-19 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Methods and catalyst systems for carbon dioxide conversion

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748342A (en) * 1971-05-06 1973-07-24 Sandoz Ag Intermediates for preparing quinazolinones
US3794642A (en) * 1973-01-15 1974-02-26 Lilly Co Eli Oxidation of substituted methanes to the corresponding substituted methanols
US4560510A (en) * 1984-04-06 1985-12-24 A. H. Robins Company, Incorporated Process and intermediates for the preparation of aryl substituted pyrido[1,4]benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
DE68926417T2 (de) * 1988-02-12 1996-09-12 Daicel Chem Verfahren zur herstellung von optisch aktiven 2-hydroxysäureabkömmlingen
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219777B (hu) * 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására

Also Published As

Publication number Publication date
PE32896A1 (es) 1996-08-07
YU49349B (sh) 2005-07-19
HU223846B1 (hu) 2005-02-28
YU49288B (sh) 2005-03-15
SI0699677T1 (en) 2003-06-30
MY117754A (en) 2004-08-30
ZA957279B (en) 1997-02-28
ZA957280B (en) 1997-02-28
SI0699678T1 (en) 2004-06-30
HU0003319D0 (sh) 1995-08-30
UA45309C2 (uk) 2002-04-15
US6329364B1 (en) 2001-12-11
KR960007596A (ko) 1996-03-22
UA44698C2 (uk) 2002-03-15
YU49289B (sh) 2005-03-15
YU57895A (sh) 1998-07-10
TW393485B (en) 2000-06-11
PE28196A1 (es) 1996-07-04
CO4410197A1 (es) 1997-01-09
KR100386934B1 (ko) 2003-10-04
YU57695A (sh) 1998-07-10
TW390881B (en) 2000-05-21
MY118394A (en) 2004-10-30
CO4410199A1 (es) 1997-01-09
KR100386933B1 (ko) 2003-09-19
KR960007597A (ko) 1996-03-22
US5665878A (en) 1997-09-09
PE32996A1 (es) 1996-08-10
TW372965B (en) 1999-11-01
ZA957278B (en) 1997-02-28
UA41354C2 (uk) 2001-09-17
RU2142465C1 (ru) 1999-12-10
NZ272896A (en) 1997-03-24
US6288057B1 (en) 2001-09-11
CO4410198A1 (es) 1997-01-09

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