YU49092A - DERIVATIVES OF AMINO ACIDS - Google Patents

DERIVATIVES OF AMINO ACIDS

Info

Publication number
YU49092A
YU49092A YU49092A YU49092A YU49092A YU 49092 A YU49092 A YU 49092A YU 49092 A YU49092 A YU 49092A YU 49092 A YU49092 A YU 49092A YU 49092 A YU49092 A YU 49092A
Authority
YU
Yugoslavia
Prior art keywords
compounds
formula
group
alkoxycarbonyl
alkyl
Prior art date
Application number
YU49092A
Other languages
Serbo-Croatian (sh)
Inventor
J.A. Marin
G.J. Thomas
Original Assignee
F. Hoffmann La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann La Roche Ag. filed Critical F. Hoffmann La Roche Ag.
Publication of YU49092A publication Critical patent/YU49092A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DERIVATI AMINOKISELINA, opisana su jedinjenja opšte formule u kojima; R1 predstavlja alkoksikarbonil, aralkoksikarbonil, alkanoil, aralkanoil, heterociklilkarbonil ili grupu formule R2 predstavlja alkil, cikloalkilalkil ili aralkil; R3 predstavlja vodonik i R4 predstavlja hidroksi ili R3 i R4 zajedno predstavljaju oko; R5 predstavlja alkoksikarbonil ili alkilkarbamoil; R6 i R7 zajedno predstavljaju trimetilen ili tetrametilen opciono supstituisan sa alkil grupom ili na susednim ugljenikovim atomima sa tetrametilen grupom; R8 predstavlja alkoksikarbonil, aralkoksikarbonil, alkanoil, aroil, aralkanoil ili heterociklilkarbonil; i R9 predstavlja alkil, cikloalkil, cikloalkilalkil, aralkil, cijanoalkil, karbamoilalkil, alkiltioalkil, alkoksialkil ili alkoksikarbonilalkil, i njihove farmaceutski prihvatljive adicione soli sa kisclinama onih jedinjenja formule I koja su bazna, i koja inhibiraju aspartil proteaze virusnog porekla i mogu se upotrebiti u formi medikamenata za profilaktiče svrhe ili za lečenje virusnih infekcija: Jedinjenja u pitanju se mogu dobiti primenom opšte poznatih metoda.AMINO ACID DERIVATIVES, compounds of general formula are described in which; R 1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, heterocyclylcarbonyl or a group of formula R 2 represents alkyl, cycloalkylalkyl or aralkyl; R3 represents hydrogen and R4 represents hydroxy or R3 and R4 together represent about; R5 represents alkoxycarbonyl or alkylcarbamoyl; R6 and R7 together represent trimethylene or tetramethylene optionally substituted with an alkyl group or on adjacent carbon atoms with a tetramethylene group; R8 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aroyl, aralkanoyl or heterocyclylcarbonyl; and R 9 represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, cyanoalkyl, carbamoylalkyl, alkylthioalkyl, alkoxyalkyl or alkoxycarbonylalkyl, and their pharmaceutically acceptable acid addition salts of those compounds of formula I which are basic and which can inhibit the virus drugs for prophylactic purposes or for the treatment of viral infections: The compounds in question can be obtained using generally known methods.

YU49092A 1991-05-10 1992-05-08 DERIVATIVES OF AMINO ACIDS YU49092A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110170A GB9110170D0 (en) 1991-05-10 1991-05-10 Amino acid derivatives
GB929203014A GB9203014D0 (en) 1991-05-10 1992-02-13 Amino acid derivatives

Publications (1)

Publication Number Publication Date
YU49092A true YU49092A (en) 1995-03-27

Family

ID=10694788

Family Applications (1)

Application Number Title Priority Date Filing Date
YU49092A YU49092A (en) 1991-05-10 1992-05-08 DERIVATIVES OF AMINO ACIDS

Country Status (8)

Country Link
KR (1) KR100220987B1 (en)
BR (1) BR9201771A (en)
GB (2) GB9110170D0 (en)
RU (1) RU2109731C1 (en)
TW (1) TW264462B (en)
UY (1) UY23413A1 (en)
YU (1) YU49092A (en)
ZA (1) ZA923184B (en)

Also Published As

Publication number Publication date
ZA923184B (en) 1993-10-04
UY23413A1 (en) 1992-11-05
KR920021495A (en) 1992-12-18
GB9203014D0 (en) 1992-03-25
BR9201771A (en) 1992-12-29
KR100220987B1 (en) 1999-10-01
GB9110170D0 (en) 1991-07-03
TW264462B (en) 1995-12-01
RU2109731C1 (en) 1998-04-27

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