YU43190A - AMINO ACID DERIVATIVES - Google Patents
AMINO ACID DERIVATIVESInfo
- Publication number
- YU43190A YU43190A YU43190A YU43190A YU43190A YU 43190 A YU43190 A YU 43190A YU 43190 A YU43190 A YU 43190A YU 43190 A YU43190 A YU 43190A YU 43190 A YU43190 A YU 43190A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- represents hydrogen
- alkoxycarbonyl
- hydroxy
- represent
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
DERIVATI AMINOKISELINA .Jedinjenja formule I u kojoj R1 pretstavlja alkoksikarbonil, aralkoksikarbonil, alkanoil, aralkanoil, aroil, cikloalkilkarbonil, heterociklilkarbonil, heterociklil-alkanoil, 6-(dibenzilkarbamoil)-4-oksoheksanoil ili grupu acil alfa-aminokiseline u kojoj je grupa amino supstituisana sa alkoksikarbonil, aralkoksikarbonil, diaralkilkarbamoil, diaralkilalkanoil ili aralkanoil; R2 pretstavlja alkil, cikloalkilalkil ili aralkil; R3 pretstavlja vodonik ili alkil; R4 pretstavlja alkil; a jedan od R5 i R6 pretstavlja vodonik dok drugi pretstavlja vodonik, alkil, aril, aralkil, 1-alkoksikarbonil-2-feniletil, 1-alkoksikarbonil-2-(imidazol-4-il) etil, 2-(imidazol-1-il) etil, indanil, heterociklil-alkil, karboksialkil, alkoksikarbonilalkil, ariloksikarbonilalkil, aralkoksikarbonilalkil ili grupa formule -A-N(Ra) (Rb) u kojoj A pretstavlja alkilen a Ra i Rb, svaki za sebe, pretstavljaju alkil ili Ra i Rb zajedno pretstavljaju grupu pentametilen u kojoj jedna grupa metilena može da bude zamenjena sa NH,N-alkil, N-alkanoil, N-aralkoksikarbonil, O,S,SO ili SO2; ili R5 i R6 zajedno sa atomom azota za koji su pričvršćeni pretstavljaju prsten 1,2,3,4-tetra-hidroizohinolina; jedan od W i X pretstavlja vodonik a drugi pretstavlja hidroksi ili amino ili W i X zajedno pretstavljaju hidroksi-imino a Y pretstavlja vodonik ili, kada jedan od W i X pretstavlja vodonik a drugi pretstavlja hidroksi, Y može takodje da pretstavlja hidroksi, i njihove farmaceutski prihvatljive soli koje nastaju dodavanjem kiseline, mogu se koristiti kao lekovi za lečenje i profilaksu virusnih infekcija, a posebno infekcija izazvanih virusom HIV i drugim retrovirusima. Ona se mogu proizvoditi po postupcima koji su opšte poznati.AMINO ACID DERIVATIVES Compounds of formula I in which R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, aroyl, cycloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyl-alkanoyl, 6- (dibenzylcarbamoyl-acanoyl-amino) -4- alkoxycarbonyl, aralkoxycarbonyl, diaralkylcarbamoyl, diaralkylalkanoyl or aralkanoyl; R2 represents alkyl, cycloalkylalkyl or aralkyl; R3 represents hydrogen or alkyl; R4 represents alkyl; and one of R5 and R6 represents hydrogen while the other represents hydrogen, alkyl, aryl, aralkyl, 1-alkoxycarbonyl-2-phenylethyl, 1-alkoxycarbonyl-2- (imidazol-4-yl) ethyl, 2- (imidazol-1-yl ) ethyl, indanyl, heterocyclyl-alkyl, carboxyalkyl, alkoxycarbonylalkyl, aryloxycarbonylalkyl, aralkoxycarbonylalkyl or a group of formula -AN (Ra) (Rb) in which A represents alkylene and Ra and Rb, each independently, represent a group alkyl or Ra together pentamethylene in which one methylene group may be replaced by NH, N-alkyl, N-alkanoyl, N-aralkoxycarbonyl, O, S, SO or SO2; or R5 and R6 together with the nitrogen atom to which they are attached represent a 1,2,3,4-tetrahydroisoquinoline ring; one of W and X represents hydrogen and the other represents hydroxy or amino or W and X together represent hydroxy-imino and Y represents hydrogen or, when one of W and X represents hydrogen and the other represents hydroxy, Y may also represent hydroxy, and their pharmaceutically acceptable acid addition salts can be used as medicaments for the treatment and prophylaxis of viral infections, in particular infections caused by HIV and other retroviruses. They can be produced by methods that are generally known.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU43190A YU43190A (en) | 1990-03-05 | 1990-03-05 | AMINO ACID DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU43190A YU43190A (en) | 1990-03-05 | 1990-03-05 | AMINO ACID DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU43190A true YU43190A (en) | 1992-12-21 |
Family
ID=47277927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU43190A YU43190A (en) | 1990-03-05 | 1990-03-05 | AMINO ACID DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| YU (1) | YU43190A (en) |
-
1990
- 1990-03-05 YU YU43190A patent/YU43190A/en unknown
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