UY25080A1 - AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS - Google Patents

AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS

Info

Publication number
UY25080A1
UY25080A1 UY25080A UY25080A UY25080A1 UY 25080 A1 UY25080 A1 UY 25080A1 UY 25080 A UY25080 A UY 25080A UY 25080 A UY25080 A UY 25080A UY 25080 A1 UY25080 A1 UY 25080A1
Authority
UY
Uruguay
Prior art keywords
amino acid
acid derivatives
formula
relates
alkyl
Prior art date
Application number
UY25080A
Other languages
Spanish (es)
Inventor
Gareth John Thomas
Joseph Armstrong Martin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to UY25080A priority Critical patent/UY25080A1/en
Publication of UY25080A1 publication Critical patent/UY25080A1/en

Links

Abstract

La presente invención se refiere a derivados de aminoácidos, más particularmente se refiere a derivados de aminoácidos de la fórmula (I), y sales de adición de ácido farmacéuticamente aceptables de aquellos compuestos de la fórmula (I) que son básicos, en donde: R1 representa alcoxicarbonilo, aralcoxicarbonilo, alcanoilo, aralcanoilo, heterociclilcarbonilo o R8HN-CR9-CO-CH3; R2 representa alquilo, cicloalquilalquilo o aralquilo; R3 representa hidrógeno y R4 representa hidroxilo o R3 y R4 representan oxo; R5 representa alcoxicarbonilo o alquilcarbamoilo; R6 y R7 juntos representan trimetileno o tetrametileno opcionalmente sustituido por alquilo o en átomos de carbono adyacentes por tetrametileno. Por ejemplo: 2(S)-(3(S)-((N-(benciloxicarbonil)-3-ciano-L-alanil)amino)-2®-hidroxi-4-fenilbutil)-N-terci.butil-1®-ciclohexancarboxamida. La presente invención se refiere también a un procedimiento para la preparación de compuestos de fórmula (I). Se utilizan para la profilaxis o el tratamiento de infecciones virales.The present invention relates to amino acid derivatives, more particularly relates to amino acid derivatives of formula (I), and pharmaceutically acceptable acid addition salts of those compounds of formula (I) which are basic, wherein: R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralcanoyl, heterocyclylcarbonyl or R8HN-CR9-CO-CH3; R2 represents alkyl, cycloalkylalkyl or aralkyl; R3 represents hydrogen and R4 represents hydroxyl or R3 and R4 represent oxo; R5 represents alkoxycarbonyl or alkylcarbamoyl; R6 and R7 together represent trimethylene or tetramethylene optionally substituted by alkyl or in adjacent carbon atoms by tetramethylene. For example: 2 (S) - (3 (S) - ((N- (benzyloxycarbonyl) -3-cyano-L-alanyl) amino) -2®-hydroxy-4-phenylbutyl) -N-tert.butyl-1 ®-cyclohexancarboxamide. The present invention also relates to a process for the preparation of compounds of formula (I). They are used for the prophylaxis or treatment of viral infections.

UY25080A 1998-06-02 1998-06-02 AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS UY25080A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY25080A UY25080A1 (en) 1998-06-02 1998-06-02 AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UY25080A UY25080A1 (en) 1998-06-02 1998-06-02 AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS

Publications (1)

Publication Number Publication Date
UY25080A1 true UY25080A1 (en) 2001-03-16

Family

ID=38812090

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25080A UY25080A1 (en) 1998-06-02 1998-06-02 AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS

Country Status (1)

Country Link
UY (1) UY25080A1 (en)

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20121206