UY25080A1 - AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS - Google Patents
AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTSInfo
- Publication number
- UY25080A1 UY25080A1 UY25080A UY25080A UY25080A1 UY 25080 A1 UY25080 A1 UY 25080A1 UY 25080 A UY25080 A UY 25080A UY 25080 A UY25080 A UY 25080A UY 25080 A1 UY25080 A1 UY 25080A1
- Authority
- UY
- Uruguay
- Prior art keywords
- amino acid
- acid derivatives
- formula
- relates
- alkyl
- Prior art date
Links
Abstract
La presente invención se refiere a derivados de aminoácidos, más particularmente se refiere a derivados de aminoácidos de la fórmula (I), y sales de adición de ácido farmacéuticamente aceptables de aquellos compuestos de la fórmula (I) que son básicos, en donde: R1 representa alcoxicarbonilo, aralcoxicarbonilo, alcanoilo, aralcanoilo, heterociclilcarbonilo o R8HN-CR9-CO-CH3; R2 representa alquilo, cicloalquilalquilo o aralquilo; R3 representa hidrógeno y R4 representa hidroxilo o R3 y R4 representan oxo; R5 representa alcoxicarbonilo o alquilcarbamoilo; R6 y R7 juntos representan trimetileno o tetrametileno opcionalmente sustituido por alquilo o en átomos de carbono adyacentes por tetrametileno. Por ejemplo: 2(S)-(3(S)-((N-(benciloxicarbonil)-3-ciano-L-alanil)amino)-2®-hidroxi-4-fenilbutil)-N-terci.butil-1®-ciclohexancarboxamida. La presente invención se refiere también a un procedimiento para la preparación de compuestos de fórmula (I). Se utilizan para la profilaxis o el tratamiento de infecciones virales.The present invention relates to amino acid derivatives, more particularly relates to amino acid derivatives of formula (I), and pharmaceutically acceptable acid addition salts of those compounds of formula (I) which are basic, wherein: R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralcanoyl, heterocyclylcarbonyl or R8HN-CR9-CO-CH3; R2 represents alkyl, cycloalkylalkyl or aralkyl; R3 represents hydrogen and R4 represents hydroxyl or R3 and R4 represent oxo; R5 represents alkoxycarbonyl or alkylcarbamoyl; R6 and R7 together represent trimethylene or tetramethylene optionally substituted by alkyl or in adjacent carbon atoms by tetramethylene. For example: 2 (S) - (3 (S) - ((N- (benzyloxycarbonyl) -3-cyano-L-alanyl) amino) -2®-hydroxy-4-phenylbutyl) -N-tert.butyl-1 ®-cyclohexancarboxamide. The present invention also relates to a process for the preparation of compounds of formula (I). They are used for the prophylaxis or treatment of viral infections.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UY25080A UY25080A1 (en) | 1998-06-02 | 1998-06-02 | AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UY25080A UY25080A1 (en) | 1998-06-02 | 1998-06-02 | AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25080A1 true UY25080A1 (en) | 2001-03-16 |
Family
ID=38812090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25080A UY25080A1 (en) | 1998-06-02 | 1998-06-02 | AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS |
Country Status (1)
Country | Link |
---|---|
UY (1) | UY25080A1 (en) |
-
1998
- 1998-06-02 UY UY25080A patent/UY25080A1/en not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20121206 |