YU48933B - Hidroxamic acid derivatives with three ring substituents - Google Patents
Hidroxamic acid derivatives with three ring substituentsInfo
- Publication number
- YU48933B YU48933B YU24795A YU24795A YU48933B YU 48933 B YU48933 B YU 48933B YU 24795 A YU24795 A YU 24795A YU 24795 A YU24795 A YU 24795A YU 48933 B YU48933 B YU 48933B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- atom
- oxo
- carbamoyl
- amino
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Jedinjenja opšte formule naznačena time, što u istoj R1 predstavlja ciklopropil, ciklobutil, ciklopentil ili cikloheksil; R2 predstavlja zasićeni 5- ili 8-člani monociklični ili premošćeni N-heterociklični prsten, vezan preko N atoma i koji, kada je monociličan, po želji sadrži NR4, O, S, SO ili SO2 kao člana prstena i/ili je po želji supstituisan na jednom ili više C atoma sa hidroksi, (C1-C6)alkilom, (C1-C6)alkoksi, okso, ketalizovanom okso, amino, mono (C1-C6 alkil)amino, di(C1-C6 alkil)amino, karboksi, (C1-C6)alkoksikarbonil, hidroksimetil, (C1-C6)alkoksimetil, karbamoil, mono(C1-C6 alkil)karbamoil, di(C1-C6 alkil)karbamoil ili hidroksiimino; R3 predstavlja 5- ili 6-člani N-heterocilični prsten, koji je (a) vezan preko N atoma, (b) po želji sadrži N, O i/ili S, SO ili SO2 kao dopunskog člana prstena, (c) supstituisan je sa okso na jednom ili oba C atoma, susednih veznom N atomu i (d) po želji je benz-vezan ili po želji supstituisan na jednom ili više C atoma sa (C1-C6)alkil ili okso i/ili na bilo kojem dopunsko(i)m N atomu(ima) sa (C1-C6)alkil ili aril; R4 predstavlja vodonik, (C1-C6)alkil, aril, ar(C1-C6)alkil ili neku zaštitnu grupu; m je 1 ili 2; i n je 1 - 4; i njihove farmaceutski prihvatljive soli. Prijava sadrži još 5 nezavisnih i 20 zavisna zahteva.Compounds of the general formula wherein in the same R 1 represents cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; R2 represents a saturated 5- or 8-membered monocyclic or bridged N-heterocyclic ring, bonded via an N atom and which, when monocyclic, optionally contains NR4, O, S, SO or SO2 as a ring member and / or is optionally substituted on one or more C atoms with hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, oxo, ketalised oxo, amino, mono (C1-C6 alkyl) amino, di (C1-C6 alkyl) amino, carboxy, (C1-C6) alkoxycarbonyl, hydroxymethyl, (C1-C6) alkoxymethyl, carbamoyl, mono (C1-C6 alkyl) carbamoyl, di (C1-C6 alkyl) carbamoyl or hydroxyimino; R3 represents a 5- or 6-membered N-heterocyclic ring, which is (a) bonded via the N atom, (b) optionally contains N, O and / or S, SO or SO2 as an adjunct member of the ring, (c) substituted with oxo on one or both C atoms adjacent to the bonding N atom and (d) is optionally benz-linked or optionally substituted on one or more C atoms by (C1-C6) alkyl or oxo and / or any additional ( i) an N atom (having) with (C 1 -C 6) alkyl or aryl; R4 represents hydrogen, (C1-C6) alkyl, aryl, ar (C1-C6) alkyl, or a protecting group; m is 1 or 2; and n is 1 - 4; and pharmaceutically acceptable salts thereof. The application contains 5 more independent and 20 dependent requests.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9408183A GB9408183D0 (en) | 1994-04-25 | 1994-04-25 | Hydroxamic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU24795A YU24795A (en) | 1997-12-05 |
| YU48933B true YU48933B (en) | 2002-12-10 |
Family
ID=10754086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU24795A YU48933B (en) | 1994-04-25 | 1995-04-17 | Hidroxamic acid derivatives with three ring substituents |
Country Status (10)
| Country | Link |
|---|---|
| BR (1) | BR9501765A (en) |
| CO (1) | CO4370021A1 (en) |
| GB (1) | GB9408183D0 (en) |
| HR (1) | HRP950251B1 (en) |
| PE (1) | PE2496A1 (en) |
| PL (1) | PL179129B1 (en) |
| SV (1) | SV1995000020A (en) |
| UY (1) | UY23953A1 (en) |
| YU (1) | YU48933B (en) |
| ZA (1) | ZA953123B (en) |
-
1994
- 1994-04-25 GB GB9408183A patent/GB9408183D0/en active Pending
-
1995
- 1995-04-03 PE PE26555495A patent/PE2496A1/en not_active Application Discontinuation
- 1995-04-17 YU YU24795A patent/YU48933B/en unknown
- 1995-04-18 ZA ZA953123A patent/ZA953123B/en unknown
- 1995-04-24 PL PL30832795A patent/PL179129B1/en unknown
- 1995-04-24 UY UY23953A patent/UY23953A1/en not_active IP Right Cessation
- 1995-04-24 BR BR9501765A patent/BR9501765A/en not_active Application Discontinuation
- 1995-04-24 SV SV1995000020A patent/SV1995000020A/en unknown
- 1995-04-24 CO CO95016836A patent/CO4370021A1/en unknown
- 1995-04-25 HR HRP950251 patent/HRP950251B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| YU24795A (en) | 1997-12-05 |
| PL308327A1 (en) | 1995-10-30 |
| GB9408183D0 (en) | 1994-06-15 |
| PL179129B1 (en) | 2000-07-31 |
| CO4370021A1 (en) | 1996-10-07 |
| SV1995000020A (en) | 1995-10-04 |
| UY23953A1 (en) | 1995-10-16 |
| BR9501765A (en) | 1995-11-21 |
| ZA953123B (en) | 1996-01-09 |
| HRP950251A2 (en) | 1997-08-31 |
| HRP950251B1 (en) | 2001-06-30 |
| PE2496A1 (en) | 1996-02-12 |
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