PE2496A1 - HYDROXAMIC ACID DERIVATIVES - Google Patents

HYDROXAMIC ACID DERIVATIVES

Info

Publication number
PE2496A1
PE2496A1 PE26555495A PE26555495A PE2496A1 PE 2496 A1 PE2496 A1 PE 2496A1 PE 26555495 A PE26555495 A PE 26555495A PE 26555495 A PE26555495 A PE 26555495A PE 2496 A1 PE2496 A1 PE 2496A1
Authority
PE
Peru
Prior art keywords
replaced
atom
piperidine
preference
compound
Prior art date
Application number
PE26555495A
Other languages
Spanish (es)
Inventor
Michael John Broadhurst
William Henry Johnson
Paul Anthony Brown
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE2496A1 publication Critical patent/PE2496A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) R1 ES CICLOPROPILO, CICLOBUTILO, CICLOPENTILO, CICLOHEXILO; 2) R2 ES UN ANILLO N-HETEROCICLICO DE 5 A 8 MIEMBROS QUE ESTA UNIDO VIA EL ATOMO DE N, CUANDO ES MONOCICLICO PUEDE CONTENER A NR4, O, SO, SO2 COMO UN MIEMBRO DE ANILLO Y PUEDE ESTAR SUSTITUIDO; DE PREFERENCIA ES: 4-HIDROXI-PIPERIDINO; 3-AZABICICLO-(3.2.2)NONANO; PIPERIDINA; TETRAHIDRO-1,4-TIAZINA; HEXAHIDROAZEPINA; PIRROLIDINA; MORFOLINA; 4-FENILPIPERACINA; TIAZOLIDINCARBOXAMIDA; 3) R3 ES UN ANILLO N-HETEROCICLICO PENTAGONAL O HEXAGONAL QUE ESTA UNIDO VIA EL ATOMO DE NITROGENO, OPCIONALMENTE CONTIENE N, O, S, SO, SO2 COMO UN MIEMBRO DE ANILLO ADICIONAL, ESTA SUSTITUIDO POR OXO EN UNO O AMBOS ATOMOS DE C ADYACENTES AL ATOMO DE N DE ENLACE, PUEDE ESTAR OPCIONALMENTE BENZOFUSIONADO O SUSTITUIDO; DE PREFERENCIA ES: 3,4,4-TRIMETIL-2,5-DIOXO-1-IMIDAZOLIDINILO; FTALIMIDOETIL; 5,5-DIMETIL-2,4-OXO-3-OXAZOLIDINIL; 4) m ES 1 o 2; n VARIA DE 1 A 4; DICHO COMPUESTO PUEDE SER UTIL COMO INHIBIDOR DE COLAGENASA Y USARSE EN EL CONTROL DE ARTRITIS REUMATOIDE, OSTEOARTRITIS, ATEROSCLEROSIS, ESCLEROSIS MULTIPLE Y TRATAMIENTO DE TUMORES INVASIVOSIT REFERS TO A COMPOUND OF FORMULA I WHERE: 1) R1 IS CYCLOPROPIL, CYCLOBUTYL, CYCLOPHENTIL, CYCLLOHEXYL; 2) R2 IS A N-HETEROCICLICO RING OF 5 TO 8 MEMBERS THAT IS UNITED VIA THE ATOM OF N, WHEN IT IS MONOCYCLIC, MAY CONTAIN NR4, O, SO, SO2 AS A RING MEMBER AND MAY BE REPLACED; OF PREFERENCE IS: 4-HYDROXY-PIPERIDINE; 3-AZABICICLO- (3.2.2) NONANO; PIPERIDINE; TETRAHYDRO-1,4-THIAZINE; HEXAHIDROAZEPINA; PIRROLIDINE; MORPHOLINE; 4-PHENYLPIPERACINE; THIAZOLIDINCARBOXAMIDE; 3) R3 IS A PENTAGONAL OR HEXAGONAL N-HETERO CYCLIC RING THAT IS UNITED VIA THE NITROGEN ATOM, OPTIONALLY CONTAINS N, O, S, SO, SO2 AS AN ADDITIONAL RING MEMBER, IS REPLACED BY OX IN ONE OR BOTH ATOMS OF C ADJACENT TO THE LINK ATOM, MAY BE OPTIONALLY BENZOFUSED OR REPLACED; PREFERENCE IS: 3,4,4-TRIMETHYL-2,5-DIOXO-1-IMIDAZOLIDINYL; FTALIMIDOETIL; 5,5-DIMETIL-2,4-OXO-3-OXAZOLIDINIL; 4) m IS 1 or 2; n VARIATION FROM 1 TO 4; SUCH A COMPOUND MAY BE USEFUL AS A COLLAGENASE INHIBITOR AND USED IN THE CONTROL OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, Atherosclerosis, MULTIPLE SCLEROSIS AND TREATMENT OF INVASIVE TUMORS

PE26555495A 1994-04-25 1995-04-03 HYDROXAMIC ACID DERIVATIVES PE2496A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9408183A GB9408183D0 (en) 1994-04-25 1994-04-25 Hydroxamic acid derivatives

Publications (1)

Publication Number Publication Date
PE2496A1 true PE2496A1 (en) 1996-02-12

Family

ID=10754086

Family Applications (1)

Application Number Title Priority Date Filing Date
PE26555495A PE2496A1 (en) 1994-04-25 1995-04-03 HYDROXAMIC ACID DERIVATIVES

Country Status (10)

Country Link
BR (1) BR9501765A (en)
CO (1) CO4370021A1 (en)
GB (1) GB9408183D0 (en)
HR (1) HRP950251B1 (en)
PE (1) PE2496A1 (en)
PL (1) PL179129B1 (en)
SV (1) SV1995000020A (en)
UY (1) UY23953A1 (en)
YU (1) YU48933B (en)
ZA (1) ZA953123B (en)

Also Published As

Publication number Publication date
PL308327A1 (en) 1995-10-30
SV1995000020A (en) 1995-10-04
BR9501765A (en) 1995-11-21
HRP950251A2 (en) 1997-08-31
HRP950251B1 (en) 2001-06-30
YU24795A (en) 1997-12-05
UY23953A1 (en) 1995-10-16
ZA953123B (en) 1996-01-09
CO4370021A1 (en) 1996-10-07
YU48933B (en) 2002-12-10
PL179129B1 (en) 2000-07-31
GB9408183D0 (en) 1994-06-15

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed