SV1995000020A - DERIVATIVES OF HYDROXAMIC ACID WITH TRICYCLIC SUBSTITUTION. REF. RAN 4070/95 - Google Patents

DERIVATIVES OF HYDROXAMIC ACID WITH TRICYCLIC SUBSTITUTION. REF. RAN 4070/95

Info

Publication number
SV1995000020A
SV1995000020A SV1995000020A SV1995000020A SV1995000020A SV 1995000020 A SV1995000020 A SV 1995000020A SV 1995000020 A SV1995000020 A SV 1995000020A SV 1995000020 A SV1995000020 A SV 1995000020A SV 1995000020 A SV1995000020 A SV 1995000020A
Authority
SV
El Salvador
Prior art keywords
lower alkyl
optionally
amino
hidero
atomos
Prior art date
Application number
SV1995000020A
Other languages
Spanish (es)
Inventor
Michael John Broadhust
Paul Anthony Brown
Willian Henry Johnson
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SV1995000020A publication Critical patent/SV1995000020A/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EL INVENTO PROPORCIONA DERIVADOS DE ACIDO HIDROXAMICO DE LA FORMULA GENERAL, EN DONDE R1 REPRESENTA CICLOPROPILO, CICLOPENTILO O CICLOHEXILO; R2 REPRESENTA UN ANILLO N-HETEROCICLICO MONOCICLICO O PUENTEADO DE 5 A 8 MIEMBROS SATURADO QUE ESTA UNIDO VIA EL ATOMO DE N Y QUE, CUANDO ES MONOCICLICO, CONTIENE OPCIONALMENTE NR4, O, SO ó S02 COMO UN MIEMBRO DE ANILLO Y/O ESTA OPCIONALMENTE SUSTITUIDO EN UNO O MAS ATOMOS DE C HIDROXILO, ALQUILO INFERIOR, ALCOXILO, OXO, OXOCETALIZADO, AMINO, MONO(ALQUILO INFERIOR)AMINO,DI (ALQUILO INFERIOR)AMINO, CARBOXILO, ALCOXICARBONILO INFERIOR, HIDROXIMETILO, ALCOXIMETILO INFERIOR, CARBAMOILO, MONO(ALQUILO INFERIOR)-CARBAMOILO, DI (ALQUILO INFERIOR) CARBAMOILO O HIDROXIIMINO; R3 REPRESENTA UN ANILLO N-HETEROCICLICO PENTAGONAL O HEXAGONAL QUE (A) ESTA UNIDO VIA EL ATOMO DE N, (B) OPCIONALMENTE CONTIENE N, O Y/O S, S0 ó S02 COMO UN MIEMBRO DE ANILLO ADICIONAL, (C) ESTA SUSTITUIDO POR OXO EN UNO O AMBOS ATOMOS DE C ADYACENTE AL ATOMO DE N DE ENLACE Y (D) ESTA OPCIONALMENTE BENZOFUSIONADO U OPCIONALMENTE SUSTITUIDO EN UNO O MAS ATOMOS DE OTROS ATOMOS DE C POR ALQUILO INFERIoR U OXO Y/O EN CUALQUIER ATOMO(S) DE N ADICIONAL(ES) POR ALQUILO INFERIOR O ARILO; R4 REPRESENTA HIDROGENO, ALQUILO INFERIOR, ARILO, ARALQUILO O UN GRUPO PROTECTOR; M SIGNIFICA 1 ó 2; Y N SIGNIFICA 1-4; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, QUE SON INHIBIDORES DE COLAGENASA UTILES EN EL CONTROL O PREVENCION DE ENFERMEDADES DE LAS ARTICULACIONES DEGENERATIVAS TAL COMO ARTRITIS REUMATOIDE Y OSTEOARTRITIS O EN EL TRATAMIENTO DE TUMORES INVASIVOS, ATEROSCLEROSIS O ESCLEROSIS MULTIPLE.PUEDEN PREPARARSE HIDROXAMINADO UN ACIDO CARBOXILICO NUEVO CORRESPONDIENTE O DESPROTEGIENDO UN COMPUESTO BUCILOXICARBOMOILO NUEVO CORRESPONDIENTE.THE INVENTION PROVIDES HYDROXAMIC ACID DERIVATIVES FROM THE GENERAL FORMULA, WHERE R1 REPRESENTS CYCLOPROPYL, CYCLOPHENTIL OR CYCLLOHEXYL; R2 REPRESENTS A 5 TO 8 MEMBER SATURATED MONO-CYCLE OR BRIDGED N-HETERO CYCLIC RING THAT IS UNITED VIA THE NY ATOM WHICH, WHEN IT IS MONOCYCLIC, CONTAINS OPTIONALLY NR4, OR, SO OR S02 AS A RING MEMBER AND / OR IS OPTIONALLY SUBSTITUTED IN ONE OR MORE ATOMS OF C HYDROXYL, LOWER ALKYL, ALCOXYL, OX, OXOCETALLIZED, AMINO, MONO (LOWER ALKYL) AMINO, DI (LOWER ALKYL) AMINO, CARBOXYL, ALCOXICARBONYL, HIDERO, HIDERO ) -CARBAMOIL, DI (LOWER ALKYL), CARBAMOIL OR HYDROXYIMINE; R3 REPRESENTS A PENTAGONAL OR HEXAGONAL N-HETERO CYCLIC RING THAT (A) IS UNITED VIA THE ATOM OF N, (B) OPTIONALLY CONTAINS N, OY / OS, S0 OR S02 AS AN ADDITIONAL RING MEMBER, (C) IS REPLACED BY OXO IN ONE OR BOTH ATOMS OF C ADJACENT TO THE ATOMO DE N DE ENLACE AND (D) IT IS OPTIONALLY BENZOFUSED OR OPTIONALLY SUBSTITUTED IN ONE OR MORE ATOMOS OF OTHER ATOMOS DE C BY ANY INFERIOR OR OXO AND / OR IN ANY ATOMO (S) ADDITIONAL (S) FOR LOWER RENT OR ARIL; R4 REPRESENTS HYDROGEN, LOWER RENT, ARYL, ARACHYL OR A PROTECTIVE GROUP; M MEANS 1 or 2; Y N MEANS 1-4; AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, WHICH ARE INHIBITORS OF COLAGENASA USEFUL IN THE CONTROL OR PREVENTION OF DISEASES OF THE DEGENERATIVE JOINTS SUCH AS ARTHRITIS RHEUMARIUM AND OSTEOARI-ESTERI-ESSTERS, ATEROSCLARS, AND ATEROSCLAR. OR DEPROTECTING A CORRESPONDING NEW BUCYLOXICARBOMOIL COMPOUND.

SV1995000020A 1994-04-25 1995-04-24 DERIVATIVES OF HYDROXAMIC ACID WITH TRICYCLIC SUBSTITUTION. REF. RAN 4070/95 SV1995000020A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9408183A GB9408183D0 (en) 1994-04-25 1994-04-25 Hydroxamic acid derivatives

Publications (1)

Publication Number Publication Date
SV1995000020A true SV1995000020A (en) 1995-10-04

Family

ID=10754086

Family Applications (1)

Application Number Title Priority Date Filing Date
SV1995000020A SV1995000020A (en) 1994-04-25 1995-04-24 DERIVATIVES OF HYDROXAMIC ACID WITH TRICYCLIC SUBSTITUTION. REF. RAN 4070/95

Country Status (10)

Country Link
BR (1) BR9501765A (en)
CO (1) CO4370021A1 (en)
GB (1) GB9408183D0 (en)
HR (1) HRP950251B1 (en)
PE (1) PE2496A1 (en)
PL (1) PL179129B1 (en)
SV (1) SV1995000020A (en)
UY (1) UY23953A1 (en)
YU (1) YU48933B (en)
ZA (1) ZA953123B (en)

Also Published As

Publication number Publication date
YU24795A (en) 1997-12-05
PL308327A1 (en) 1995-10-30
GB9408183D0 (en) 1994-06-15
PL179129B1 (en) 2000-07-31
YU48933B (en) 2002-12-10
CO4370021A1 (en) 1996-10-07
UY23953A1 (en) 1995-10-16
BR9501765A (en) 1995-11-21
ZA953123B (en) 1996-01-09
HRP950251A2 (en) 1997-08-31
HRP950251B1 (en) 2001-06-30
PE2496A1 (en) 1996-02-12

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