UY23953A1 - HYDROXAMIC ACID DERIVATIVES WITH TRICYCLIC SUBSTITUTION AND PREPARATION PROCEDURE - Google Patents
HYDROXAMIC ACID DERIVATIVES WITH TRICYCLIC SUBSTITUTION AND PREPARATION PROCEDUREInfo
- Publication number
- UY23953A1 UY23953A1 UY23953A UY23953A UY23953A1 UY 23953 A1 UY23953 A1 UY 23953A1 UY 23953 A UY23953 A UY 23953A UY 23953 A UY23953 A UY 23953A UY 23953 A1 UY23953 A1 UY 23953A1
- Authority
- UY
- Uruguay
- Prior art keywords
- atom
- atoms
- optionally
- acid derivatives
- hydroxamic acid
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de fórmula estructural (I), representada en la figura 1, y sus sales farmacéuticamente aceptables, donde: R2 representa un anillo N-heterocíclico monocíclico o puenteado de 5 a 8 miembros saturado que esta unido vía el átomo de N, y que cuando es monocíclico , contiene opcionalmente NR4, O, SO o SO2 como un miembro de anillo y/o está opcionalmente sustituido en uno o más átomos de C; R3 representa un anillo N-heterocíclico pentagonal o hexagonal que (a) está unido vía el átomo de N; (b) opcionalmente contiene N, O y/o S, SO, o SO2 como un miembro de anillo adicional; (c) está sustituido por oxo en uno o ambos átomos de C adyacentes al átomo de N de enlace y (d) está opcionalmente benzofusionado u opcionalmente sustituido en uno o más átomos de C. Ejemplo no limitante: 1-[3-ciclopropil-2-(R)-[1(R o S)-(hidroxicarbamoil)-2-(3,4,4-trimetil-2,5-dioxo-1-imidazolidinil)etil]-propionil]-4-piperidinol. Se describen procedimientos para su preparación y medicamentos que contienen estos compuestos, a su empleo para tratar enfermedades de las articulaciones degenerativas o tratamientos de tumores invasivos, aterosclerosis o esclerosis múltiple.Compounds of structural formula (I), represented in figure 1, and their pharmaceutically acceptable salts, where: R2 represents a saturated 5- to 8-membered monocyclic or bridged N-heterocyclic ring that is attached via the N atom, and that when is monocyclic, optionally contains NR4, O, SO, or SO2 as a ring member, and / or is optionally substituted on one or more C atoms; R3 represents a pentagonal or hexagonal N-heterocyclic ring which (a) is attached via the N atom; (b) optionally contains N, O and / or S, SO, or SO2 as an additional ring member; (c) is substituted by oxo on one or both of the C atoms adjacent to the bonding N atom and (d) is optionally benzofused or optionally substituted on one or more C atoms. Non-limiting example: 1- [3-cyclopropyl- 2- (R) - [1 (R or S) - (hydroxycarbamoyl) -2- (3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl) ethyl] -propionyl] -4-piperidinol. Methods for their preparation and drugs containing these compounds are described, for their use to treat degenerative joint diseases or treatments for invasive tumors, atherosclerosis or multiple sclerosis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9408183A GB9408183D0 (en) | 1994-04-25 | 1994-04-25 | Hydroxamic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23953A1 true UY23953A1 (en) | 1995-10-16 |
Family
ID=10754086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23953A UY23953A1 (en) | 1994-04-25 | 1995-04-24 | HYDROXAMIC ACID DERIVATIVES WITH TRICYCLIC SUBSTITUTION AND PREPARATION PROCEDURE |
Country Status (10)
| Country | Link |
|---|---|
| BR (1) | BR9501765A (en) |
| CO (1) | CO4370021A1 (en) |
| GB (1) | GB9408183D0 (en) |
| HR (1) | HRP950251B1 (en) |
| PE (1) | PE2496A1 (en) |
| PL (1) | PL179129B1 (en) |
| SV (1) | SV1995000020A (en) |
| UY (1) | UY23953A1 (en) |
| YU (1) | YU48933B (en) |
| ZA (1) | ZA953123B (en) |
-
1994
- 1994-04-25 GB GB9408183A patent/GB9408183D0/en active Pending
-
1995
- 1995-04-03 PE PE26555495A patent/PE2496A1/en not_active Application Discontinuation
- 1995-04-17 YU YU24795A patent/YU48933B/en unknown
- 1995-04-18 ZA ZA953123A patent/ZA953123B/en unknown
- 1995-04-24 CO CO95016836A patent/CO4370021A1/en unknown
- 1995-04-24 BR BR9501765A patent/BR9501765A/en not_active Application Discontinuation
- 1995-04-24 PL PL30832795A patent/PL179129B1/en unknown
- 1995-04-24 SV SV1995000020A patent/SV1995000020A/en unknown
- 1995-04-24 UY UY23953A patent/UY23953A1/en not_active IP Right Cessation
- 1995-04-25 HR HRP950251 patent/HRP950251B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PE2496A1 (en) | 1996-02-12 |
| PL308327A1 (en) | 1995-10-30 |
| SV1995000020A (en) | 1995-10-04 |
| BR9501765A (en) | 1995-11-21 |
| HRP950251A2 (en) | 1997-08-31 |
| HRP950251B1 (en) | 2001-06-30 |
| YU24795A (en) | 1997-12-05 |
| ZA953123B (en) | 1996-01-09 |
| CO4370021A1 (en) | 1996-10-07 |
| YU48933B (en) | 2002-12-10 |
| PL179129B1 (en) | 2000-07-31 |
| GB9408183D0 (en) | 1994-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| VENC | Patent expired |
Effective date: 20150424 |