UY23953A1 - HYDROXAMIC ACID DERIVATIVES WITH TRICYCLIC SUBSTITUTION AND PREPARATION PROCEDURE - Google Patents

HYDROXAMIC ACID DERIVATIVES WITH TRICYCLIC SUBSTITUTION AND PREPARATION PROCEDURE

Info

Publication number
UY23953A1
UY23953A1 UY23953A UY23953A UY23953A1 UY 23953 A1 UY23953 A1 UY 23953A1 UY 23953 A UY23953 A UY 23953A UY 23953 A UY23953 A UY 23953A UY 23953 A1 UY23953 A1 UY 23953A1
Authority
UY
Uruguay
Prior art keywords
atom
atoms
optionally
acid derivatives
hydroxamic acid
Prior art date
Application number
UY23953A
Other languages
Spanish (es)
Inventor
Michael John Broadhurst
Paul Anthony Brown
William Henry Johnson
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY23953A1 publication Critical patent/UY23953A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula estructural (I), representada en la figura 1, y sus sales farmacéuticamente aceptables, donde: R2 representa un anillo N-heterocíclico monocíclico o puenteado de 5 a 8 miembros saturado que esta unido vía el átomo de N, y que cuando es monocíclico , contiene opcionalmente NR4, O, SO o SO2 como un miembro de anillo y/o está opcionalmente sustituido en uno o más átomos de C; R3 representa un anillo N-heterocíclico pentagonal o hexagonal que (a) está unido vía el átomo de N; (b) opcionalmente contiene N, O y/o S, SO, o SO2 como un miembro de anillo adicional; (c) está sustituido por oxo en uno o ambos átomos de C adyacentes al átomo de N de enlace y (d) está opcionalmente benzofusionado u opcionalmente sustituido en uno o más átomos de C. Ejemplo no limitante: 1-[3-ciclopropil-2-(R)-[1(R o S)-(hidroxicarbamoil)-2-(3,4,4-trimetil-2,5-dioxo-1-imidazolidinil)etil]-propionil]-4-piperidinol. Se describen procedimientos para su preparación y medicamentos que contienen estos compuestos, a su empleo para tratar enfermedades de las articulaciones degenerativas o tratamientos de tumores invasivos, aterosclerosis o esclerosis múltiple.Compounds of structural formula (I), represented in figure 1, and their pharmaceutically acceptable salts, where: R2 represents a saturated 5- to 8-membered monocyclic or bridged N-heterocyclic ring that is attached via the N atom, and that when is monocyclic, optionally contains NR4, O, SO, or SO2 as a ring member, and / or is optionally substituted on one or more C atoms; R3 represents a pentagonal or hexagonal N-heterocyclic ring which (a) is attached via the N atom; (b) optionally contains N, O and / or S, SO, or SO2 as an additional ring member; (c) is substituted by oxo on one or both of the C atoms adjacent to the bonding N atom and (d) is optionally benzofused or optionally substituted on one or more C atoms. Non-limiting example: 1- [3-cyclopropyl- 2- (R) - [1 (R or S) - (hydroxycarbamoyl) -2- (3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl) ethyl] -propionyl] -4-piperidinol. Methods for their preparation and drugs containing these compounds are described, for their use to treat degenerative joint diseases or treatments for invasive tumors, atherosclerosis or multiple sclerosis.

UY23953A 1994-04-25 1995-04-24 HYDROXAMIC ACID DERIVATIVES WITH TRICYCLIC SUBSTITUTION AND PREPARATION PROCEDURE UY23953A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9408183A GB9408183D0 (en) 1994-04-25 1994-04-25 Hydroxamic acid derivatives

Publications (1)

Publication Number Publication Date
UY23953A1 true UY23953A1 (en) 1995-10-16

Family

ID=10754086

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23953A UY23953A1 (en) 1994-04-25 1995-04-24 HYDROXAMIC ACID DERIVATIVES WITH TRICYCLIC SUBSTITUTION AND PREPARATION PROCEDURE

Country Status (10)

Country Link
BR (1) BR9501765A (en)
CO (1) CO4370021A1 (en)
GB (1) GB9408183D0 (en)
HR (1) HRP950251B1 (en)
PE (1) PE2496A1 (en)
PL (1) PL179129B1 (en)
SV (1) SV1995000020A (en)
UY (1) UY23953A1 (en)
YU (1) YU48933B (en)
ZA (1) ZA953123B (en)

Also Published As

Publication number Publication date
PE2496A1 (en) 1996-02-12
PL308327A1 (en) 1995-10-30
SV1995000020A (en) 1995-10-04
BR9501765A (en) 1995-11-21
HRP950251A2 (en) 1997-08-31
HRP950251B1 (en) 2001-06-30
YU24795A (en) 1997-12-05
ZA953123B (en) 1996-01-09
CO4370021A1 (en) 1996-10-07
YU48933B (en) 2002-12-10
PL179129B1 (en) 2000-07-31
GB9408183D0 (en) 1994-06-15

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Legal Events

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VENC Patent expired

Effective date: 20150424