ECSP951430A - DERIVATIVES OF HYDROXAMIC ACIDS WITH TRICYCLIC SUBSTITUTION - Google Patents

Abstract

Compounds of the general formula where: R1 represents cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; R2 represents a saturated 5-8 membered monocyclic or bridged N-heterocyclic ring that is attached via the N atom and, when monocyclic, optionally contains NR41, O1, SO1, or SO2 as a ring member and / or is optionally substituted at one or more C atoms by hydroxyl, lower alkyl, lower alkoxy, oxo, oxo catalyzed, amino, mono (lower alkyl) amino, di (lower alkyl) amino, di (lower alkyl) -amino, carboxyl, alkoxycarbonyl lower, hydroxymethyl, lower alkoxymethyl, carbamoyl, mono (lower alkyl) -carbamoyl, di- (lower alkyl) -carbamoyl or hydroxyimino; R3 represents a pentagonal or hexagonal N-heterocyclic ring that (a) is attached via the N1 atom (b) optionally contains N1 O and / or S1, SO or SO2 as an additional ring member, (c) is replaced by oxo at one or both of the C atoms adjacent to the bonding N atom and (d) is optionally benzofused or optionally substituted on one or more atoms of other C atoms by lower alkyl or oxo and / or on any additional N atom (s) (s) by lower alkyl or aryl; R4 represents hydrogen, lower alkyl, aryl, aralkyl, or a protecting group; m means 1 or 2; and n means 1-4; and its pharmaceutically acceptable salts.