YU47592B - 13-alkil-23-imino i 13-halo-23-imino derivati makrolidnih jedinjenja - Google Patents
13-alkil-23-imino i 13-halo-23-imino derivati makrolidnih jedinjenjaInfo
- Publication number
- YU47592B YU47592B YU171090A YU171090A YU47592B YU 47592 B YU47592 B YU 47592B YU 171090 A YU171090 A YU 171090A YU 171090 A YU171090 A YU 171090A YU 47592 B YU47592 B YU 47592B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- imino
- halo
- alkyl
- derivatives
- macrolide compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pest Control & Pesticides (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
13-ALKIL-23-IMINO I 13-HALO-23-IMINO DERIVATI MAKROLIDNIH JEDINJENJA čija je struktura formula: naznačen time, što R1 je metil, etil ili izopropil; R7 je vodonik, i R8 je OR2, ili uzeti zajedno sa ugljenikom za koji su vezani R7 i R8 predstavljaju C=0; R2 je vodonik, C1-C4 alkil, ili ; R4 je vodonik, C1-C4 alkil, C1-C4 haloalkil, C1-C4 alkoksi, fenoksi, C1-C4 alkoksimetil, fenoksimetil, ili fenil opciono supstituisan sa 1 nitro grupom, 1-3 halogena, 1-3 C1-C4 alkil, ili 1-3 C1-C4 alkoksi; R3 je vodonik, metil ili etil; X je fluor, brom, hlor ili jod; W je kiseonik ili N=Y; Y je OR5 ili NHR6; R5 je C1-C4 alkil ili C1-C4acil; R6 je C1-C4 acil i isprekidana triangularna figura sa kiseonikom u položaju C26-C27 označava da je prisutna ili dvoguba veza ili epoksid. Jedinjenje čija je strukturna formula: naznačeno time, što R1 je C1-C4 alkil; R2 je vodonik, metil ili etil; R3 je vodonik C1-C4 alkil ili ; R5 je vodonik, C1-C4 alkil, C1-C4 haloalkil, C1-C4 alkoksi, fenoksi, C1-C4 alkoksimetil, ili fenil opciono supstituisan sa 1 nitro grupom, 1-3 halogena, 1-3 C1-C4 alkil ili 1-3 C1-C4 alkoksi grupa; R4 je metil, etil ili izopropil; X je kiseonik, NOR6 ili N-NHR7; R6 je vodonik, C1-C4 alkil, C1-C4 alkoksimetil, C1-C4alkanoil, benzil ili fenil; i R7 je C1-C4 acil, C1-C4 alkil ili benzoil. Prijava sadrži još 4 nezavisna i 4 zavisna zahteva.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9011710A SI9011710B (sl) | 1989-09-11 | 1990-09-10 | 13-alkil-23-imino in 13-halo-23-imino derivati makrolidnih spojin |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/405,808 US5030650A (en) | 1989-09-11 | 1989-09-11 | 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
| US07/455,686 US5055486A (en) | 1989-12-22 | 1989-12-22 | 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU171090A YU171090A (sh) | 1992-12-21 |
| YU47592B true YU47592B (sh) | 1995-10-24 |
Family
ID=27019245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU171090A YU47592B (sh) | 1989-09-11 | 1990-09-10 | 13-alkil-23-imino i 13-halo-23-imino derivati makrolidnih jedinjenja |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0423445B1 (sh) |
| JP (1) | JP3026827B2 (sh) |
| KR (2) | KR0160972B1 (sh) |
| CN (2) | CN1032004C (sh) |
| AT (1) | ATE130006T1 (sh) |
| AU (1) | AU631454B2 (sh) |
| BG (1) | BG60271B1 (sh) |
| BR (1) | BR9004494A (sh) |
| DE (1) | DE69023454T2 (sh) |
| DK (1) | DK0423445T3 (sh) |
| ES (1) | ES2081880T3 (sh) |
| GR (1) | GR3018033T3 (sh) |
| HU (1) | HU217357B (sh) |
| IE (1) | IE71210B1 (sh) |
| IL (1) | IL109791A (sh) |
| PL (1) | PL164168B1 (sh) |
| PT (1) | PT95241B (sh) |
| RU (1) | RU2070885C1 (sh) |
| SI (1) | SI9011710B (sh) |
| UA (1) | UA41246C2 (sh) |
| YU (1) | YU47592B (sh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988824A (en) * | 1989-09-11 | 1991-01-29 | Maulding Donald R | Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds |
| US5229416A (en) * | 1992-04-29 | 1993-07-20 | Merck & Co., Inc. | Avermectin difluoro derivatives |
| DE19654079A1 (de) | 1996-12-23 | 1998-06-25 | Bayer Ag | Endo-ekto-parasitizide Mittel |
| DE102004053964A1 (de) | 2004-11-09 | 2006-05-11 | Bayer Healthcare Ag | Mittel gegen Demodikose |
| CN105085540B (zh) * | 2015-08-12 | 2017-07-07 | 内蒙古佳瑞米精细化工有限公司 | 一种制备高含量尼莫克汀的方法 |
| WO2019152808A1 (en) | 2018-02-01 | 2019-08-08 | Yale University | Compositions and methods for inhibition of nuclear-penetrating antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ221077A (en) * | 1986-07-18 | 1990-06-26 | Ciba Geigy Ag | 13b-alkyl milbemycins and use as parasiticides |
| ATE109783T1 (de) * | 1986-09-12 | 1994-08-15 | American Cyanamid Co | 23-oxo(keto) und 23-imino-derivate von ll-f28249- verbindungen. |
| US4831016A (en) * | 1986-10-31 | 1989-05-16 | Merck & Co., Inc. | Reduced avermectin derivatives |
| US4886829A (en) * | 1987-03-06 | 1989-12-12 | American Cyanamid Company | 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds |
| US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
| US5830875A (en) * | 1989-10-30 | 1998-11-03 | Merck & Co., Inc. | 24-and 25-substituted avermectin and milbemycin derivatives |
-
1990
- 1990-08-03 ES ES90114920T patent/ES2081880T3/es not_active Expired - Lifetime
- 1990-08-03 DE DE69023454T patent/DE69023454T2/de not_active Expired - Lifetime
- 1990-08-03 AT AT90114920T patent/ATE130006T1/de not_active IP Right Cessation
- 1990-08-03 DK DK90114920.3T patent/DK0423445T3/da active
- 1990-08-03 EP EP90114920A patent/EP0423445B1/en not_active Expired - Lifetime
- 1990-08-06 IL IL10979190A patent/IL109791A/en not_active IP Right Cessation
- 1990-08-30 CN CN90107011A patent/CN1032004C/zh not_active Expired - Fee Related
- 1990-09-07 JP JP2235957A patent/JP3026827B2/ja not_active Expired - Lifetime
- 1990-09-07 PT PT95241A patent/PT95241B/pt not_active IP Right Cessation
- 1990-09-10 IE IE327490A patent/IE71210B1/en not_active IP Right Cessation
- 1990-09-10 UA UA4831124A patent/UA41246C2/uk unknown
- 1990-09-10 YU YU171090A patent/YU47592B/sh unknown
- 1990-09-10 BG BG092811A patent/BG60271B1/bg unknown
- 1990-09-10 RU SU904831124A patent/RU2070885C1/ru not_active IP Right Cessation
- 1990-09-10 BR BR909004494A patent/BR9004494A/pt not_active IP Right Cessation
- 1990-09-10 KR KR1019900014282A patent/KR0160972B1/ko not_active IP Right Cessation
- 1990-09-10 HU HU844/90A patent/HU217357B/hu not_active IP Right Cessation
- 1990-09-10 AU AU62357/90A patent/AU631454B2/en not_active Expired
- 1990-09-10 PL PL90286823A patent/PL164168B1/pl unknown
- 1990-09-10 SI SI9011710A patent/SI9011710B/sl not_active IP Right Cessation
-
1994
- 1994-11-24 CN CN94118512A patent/CN1053556C/zh not_active Expired - Fee Related
-
1995
- 1995-11-09 GR GR940403514T patent/GR3018033T3/el unknown
-
1998
- 1998-06-23 KR KR1019980023560A patent/KR0168751B1/ko not_active IP Right Cessation
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